Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Justyna Sawa‐Makarska"'
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Akademický článek
Mechanism of cargo-directed Atg8 conjugation during selective autophagy
Autor: Dorotea Fracchiolla, Justyna Sawa-Makarska, Bettina Zens, Anita de Ruiter, Gabriele Zaffagnini, Andrea Brezovich, Julia Romanov, Kathrin Runggatscher, Claudine Kraft, Bojan Zagrovic, Sascha Martens
Publikováno v: eLife, Vol 5 (2016)
Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is c
Externí odkaz: https://doaj.org/article/9e792a1fdaea4938bbb493df72516559
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5
Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin
Autor: Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Wai Kit Lam, Elias Adriaenssens, Dorotea Fracchiolla, Stephen Shoebridge, Benjamin Scott Padman, Marvin Skulsuppaisarn, Runa S.J. Lindblom, Sascha Martens, Michael Lazarou
Cargo sequestration is a fundamental step of selective autophagy in which cells generate a double membrane structure termed an autophagosome on the surface of cargoes. NDP52, TAX1BP1 and p62 bind FIP200 which recruits the ULK1/2 complex to initiate a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72f5f7926227cbd10af1584155a1be5b
https://doi.org/10.1101/2022.08.14.503930
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6
Microscopy-based bead protein-protein interaction assay v1
Autor: Justyna Sawa-Makarska
This protocol describes how to perform microscopy-based bead protein-protein interaction assay with GST-labelled proteins as baits and fluorescently labelled proteins as preys. The protocol requires to have purified proteins and allows to monitor pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d76e0968d4f6784f0f7932da6412d6
https://doi.org/10.17504/protocols.io.cdbis2ke
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7
NDP52 and OPTN S177D S473D: expression and purification v1
Autor: Justyna Sawa-Makarska
This protocol describes how to express and purify human NDP52 and OPTN S177D S473D. The same procedure can be applied to purify wild type OPTN.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a515a646d1b987cd47d10dd375ecad0d
https://doi.org/10.17504/protocols.io.bp2l61znrvqe/v1
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8
Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation
Autor: Martin Graef, Verena Baumann, Gerhard Hummer, Veronika Nogellova, Christine Abert, Nicolas Coudevylle, Justyna Sawa-Makarska, Martina Schuschnig, Sascha Martens, Sören von Bülow
Publikováno v: Science
Reconstituting autophagosome nucleation To stay healthy, our cells must constantly dispose of harmful material. Autophagy, or self-eating, is an important mechanism to ensure the clearance of bulky material. Such material is enwrapped by cellular mem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d5cd7e47a06591e17837ac77168a52
https://doi.org/10.1126/science.aaz7714
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9
Beyond Atg8 binding: The role of AIM/LIR motifs in autophagy
Autor: Justyna Sawa-Makarska, Sascha Martens, Dorotea Fracchiolla
Selective macroautophagy/autophagy mediates the selective delivery of cytoplasmic cargo material via autophagosomes into the lytic compartment for degradation. This selectivity is mediated by cargo receptor molecules that link the cargo to the phagop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab73d7c80fa4f530059f31c1564ba92b
https://europepmc.org/articles/PMC5446069/
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