[99mTc]Tc-PSMA-T4—Novel SPECT Tracer for Metastatic PCa: From Bench to Clinic

Autor: Michał Maurin, Monika Wyczółkowska, Agnieszka Sawicka, Arkadiusz Eugeniusz Sikora, Urszula Karczmarczyk, Barbara Janota, Marcin Radzik, Dominik Kłudkiewicz, Justyna Pijarowska-Kruszyna, Antoni Jaroń, Wioletta Wojdowska, Piotr Garnuszek

Publikováno v: Molecules, Vol 27, Iss 21, p 7216 (2022)

Despite significant advances in nuclear medicine for diagnosing and treating prostate cancer (PCa), research into new ligands with increasingly better biological properties is still ongoing. Prostate-specific membrane antigen (PSMA) ligands show grea

Externí odkaz: https://doaj.org/article/556af5e2d5bb4c0b94113b833c84ca41

OPTIMIZATION OF MICROWAVE ASSISTED SOLID-PHASE SYNTHESIS OF OCTREOTATE PEPTIDE AND COUPLING WITH PROTECTED BIFUNCTIONAL CHELATOR DOTA(tBu)3

Autor: Piotr Garnuszek, Antoni Jaron, Łukasz Kordowski, Arkadiusz Sikora, Justyna Pijarowska – Kruszyna, Michał Maurin

Publikováno v: Acta Poloniae Pharmaceutica - Drug Research. 77:589-600

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e458c700ff89c07344f48c2dc9b55bc2
https://doi.org/10.32383/appdr/124745

PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties

Autor: Jolanta Zaborniak, Wioletta Wojdowska, Piotr F. J. Lipiński, Monika Wyczółkowska, Piotr Garnuszek, Justyna Pijarowska-Kruszyna, Antoni Jaron, Dariusz Pawlak, Urszula Karczmarczyk, Arkadiusz Sikora, Renata Mikolajczak, Michał Maurin

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 5
'International Journal of Molecular Sciences ', vol: 22, pages: 2731-1-2731-35 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 2731, p 2731 (2021)

A new PSMA ligand (PSMA-D4) containing the Glu-CO-Lys pharmacophore connected with a new linker system (L-Trp-4-Amc) and chelator DOTA was developed for radiolabeling with therapeutic radionuclides. Herein we describe the synthesis, radiolabeling, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db84ff4456bb83ae63b1663063a9d292

Development of freeze-dried kit for one-step expeditious preparation of [99mTc]Tc-PSMA-T4

Autor: Wioletta Wojdowska, Barbara Janota, Marcin Radzik, Agnieszka Sawicka, Justyna Pijarowska-Kruszyna, Antoni Jaron, Michal Maurin, Monika Wyczólkowska, Piotr Garnuszek

Publikováno v: Nuclear Medicine and Biology. :S146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e497564fd8b59932ec5ea549a9dc4620
https://doi.org/10.1016/s0969-8051(22)00314-6

New synthesis route of active substance d,l-HMPAO for preparation Technetium Tc99m Exametazime

Autor: Justyna Pijarowska-Kruszyna, Piotr Garnuszek, Urszula Karczmarczyk, Antoni Jaron, Marcin Radzik, Ewa Laszuk, Renata Mikolajczak

Publikováno v: Nuclear Medicine Review. 20:88-94

BACKGROUND: Technetium Tc99m Exametazime (99mTc-HMPAO) is currently used as a radiopharmaceutical for determining regional cerebral blood flow and for the labelling of autologous leucocytes for infection and inflammation imaging. The HMPAO ligand exi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1dd8459029015f2308001bf494323c
https://doi.org/10.5603/nmr.2017.0014