Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Justyna Piekielna-Ciesielska"'
Autor:
Justyna Piekielna-Ciesielska, Davide Malfacini, Francine Medjiofack Djeujo, Chantal Marconato, Karol Wtorek, Girolamo Calo’, Anna Janecka
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The mu opioid receptor agonists are the most efficacious pain controlling agents but their use is accompanied by severe side effects. More recent developments indicate that some ligands can differentially activate receptor downstream pathways, possib
Externí odkaz:
https://doaj.org/article/f4a1f2d1899345fa81adb58a5b44cd70
Autor:
Karol Wtorek, Alessia Ghidini, Luca Gentilucci, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Chiara Ruzza, Chiara Sturaro, Girolamo Calò, Stefano Pieretti, Alicja Kluczyk, John McDonald, David G. Lambert, Anna Janecka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12700 (2022)
Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-
Externí odkaz:
https://doaj.org/article/819627af45404fe79afa47b69584b618
Autor:
Justyna Piekielna-Ciesielska, Adriano Mollica, Stefano Pieretti, Jakub Fichna, Agata Szymaszkiewicz, Marta Zielińska, Radzisław Kordek, Anna Janecka
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 560-566 (2018)
Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor. However, delta- and kappa-opioid receptors can also contribute to the analgesic
Externí odkaz:
https://doaj.org/article/9d8be7976dd248ffb836d7e2a503beb2
Autor:
Karol Wtorek, Piotr F. J. Lipiński, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Jarosław Sukiennik, Alicja Kluczyk, Anna Janecka
Publikováno v:
Molecules, Vol 27, Iss 1, p 151 (2021)
Our formerly described pentapeptide opioid analog Tyr-c[D-Lys-Phe-Phe-Asp]NH2 (designated RP-170), showing high affinity for the mu (MOR) and kappa (KOR) opioid receptors, was much more stable than endomorphine-2 (EM-2) in the rat brain homogenate an
Externí odkaz:
https://doaj.org/article/c146faeb9cb8454185fcfe4226b71699
Autor:
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet
Publikováno v:
Molecules, Vol 26, Iss 17, p 5406 (2021)
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use. To answer thes
Externí odkaz:
https://doaj.org/article/94ab8e3827234a1e9280634ddfec46e4
Autor:
Justyna Piekielna-Ciesielska, Roberto Artali, Ammar A. H. Azzam, David G. Lambert, Alicja Kluczyk, Luca Gentilucci, Anna Janecka
Publikováno v:
Molecules, Vol 26, Iss 1, p 13 (2020)
In recent years, G protein vs. β-arrestin biased agonism at opioid receptors has been proposed as an opportunity to produce antinociception with reduced adverse effects. However, at present this approach is highly debated, a reason why more informat
Externí odkaz:
https://doaj.org/article/d659a8d9e7104b4c86451f92d70d7db4
Autor:
Arijit Sarkar, Anna Adamska-Bartlomiejczyk, Justyna Piekielna-Ciesielska, Karol Wtorek, Alicja Kluczyk, Attila Borics, Anna Janecka
Publikováno v:
Molecules, Vol 25, Iss 18, p 4260 (2020)
The opioid receptors are members of the G-protein-coupled receptor (GPCR) family and are known to modulate a variety of biological functions, including pain perception. Despite considerable advances, the mechanisms by which opioid agonists and antago
Externí odkaz:
https://doaj.org/article/36a33d08b5164cf9a54047a9b6252a2e
Publikováno v:
Peptides. 165:171012
Autor:
Alicja Kluczyk, Anna Adamska-Bartłomiejczyk, Anna Janecka, Piotr F. J. Lipiński, Justyna Piekielna-Ciesielska
Publikováno v:
ChemMedChem. 15:1322-1329
Peptide-based agonists of the μ opioid receptor (μOR) are promising therapeutic candidates for pain relief with reduced side effects compared to morphine. A deep understanding of μOR-ligand interactions is necessary for future design of peptide-ba
Autor:
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet
Publikováno v:
Molecules
Molecules, 2021, 26 (17), pp.5406. ⟨10.3390/molecules26175406⟩
Molecules, Vol 26, Iss 5406, p 5406 (2021)
Vrije Universiteit Brussel
Volume 26
Issue 17
Molecules, 2021, 26 (17), pp.5406. ⟨10.3390/molecules26175406⟩
Molecules, Vol 26, Iss 5406, p 5406 (2021)
Vrije Universiteit Brussel
Volume 26
Issue 17
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use. To answer thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::db4713abc407f73f5cff03ba359f5172
https://hal.science/hal-03367748/file/molecules-26-05406.pdf
https://hal.science/hal-03367748/file/molecules-26-05406.pdf