Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Justyna Okarmus"'
Autor:
Justyna Okarmus, Jette Bach Agergaard, Tina C. Stummann, Henriette Haukedal, Malene Ambjørn, Kristine K. Freude, Karina Fog, Morten Meyer
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by PARK2) and the ubiquitin-specific protease 30 (USP30) have both been reported to regulate th
Externí odkaz:
https://doaj.org/article/ba8bf5e0750a40c5b1d19b65ce7c8324
Publikováno v:
Cells, Vol 13, Iss 4, p 296 (2024)
Parkinson’s disease (PD) is a common movement disorder associated with the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein
Externí odkaz:
https://doaj.org/article/253758712eb44c17b686153b96b024e1
Publikováno v:
Cells, Vol 12, Iss 4, p 651 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder that has been associated with mitochondrial dysfunction, oxidative stress, and defects in mitophagy as well as α-synuclein-positive inclusions, termed Lewy bodies (LBs), which are a common p
Externí odkaz:
https://doaj.org/article/5785b4c40f6c4fe0866bc828a6f6fdef
Autor:
Nellie A. Martin, Kirsten H. Hyrlov, Maria L. Elkjaer, Eva K. Thygesen, Agnieszka Wlodarczyk, Kirstine J. Elbaek, Christopher Aboo, Justyna Okarmus, Eirikur Benedikz, Richard Reynolds, Zoltan Hegedus, Allan Stensballe, Åsa Fex Svenningsen, Trevor Owens, Zsolt Illes
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival.Methods: By sorting CNS resident cells, microglia were the main cellular source of miR-146a. Therefore, we investigated
Externí odkaz:
https://doaj.org/article/07b96028e2194af8b68ac37fea6e76a2
Autor:
Helle Bogetofte, Pia Jensen, Justyna Okarmus, Sissel Ida Schmidt, Mikkel Agger, Matias Ryding, Peter Nørregaard, Christina Fenger, Xianmin Zeng, Jesper Graakjær, Brent James Ryan, Richard Wade-Martins, Martin Røssel Larsen, Morten Meyer
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Mutations in parkin, encoded by the PARK2 gene, causes early-onset familial Parkinson's disease (PD), but dysfunctional parkin has also been implicated in sporadic PD. By combining human isogenic induced pluripotent stem cells (iPSCs) with and withou
Externí odkaz:
https://doaj.org/article/e98e9afd23534172af5a503933362700
Autor:
Helle Bogetofte, Pia Jensen, Matias Ryding, Sissel I. Schmidt, Justyna Okarmus, Louise Ritter, Christina S. Worm, Michaela C. Hohnholt, Carla Azevedo, Laurent Roybon, Lasse K. Bak, Helle Waagepetersen, Brent J. Ryan, Richard Wade-Martins, Martin R. Larsen, Morten Meyer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to inv
Externí odkaz:
https://doaj.org/article/76001a3b4cfe44f1a503e596795f8bcb
Autor:
Matias Ryding, Mattias Gamre, Mette S. Nissen, Anna C. Nilsson, Justyna Okarmus, Anne A. E. Poulsen, Morten Meyer, Morten Blaabjerg
Publikováno v:
Cells, Vol 10, Iss 4, p 837 (2021)
Anti-IgLON5 disease is a progressive neurological disorder associated with autoantibodies against a neuronal cell adhesion molecule, IgLON5. In human postmortem brain tissue, the neurodegeneration and accumulation of hyperphosphorylated tau (p-tau) a
Externí odkaz:
https://doaj.org/article/d2e60ce216e4491d8a3e7c535fa1f1da
Autor:
Nellie A. Martin, Viktor Molnar, Gabor T. Szilagyi, Maria L. Elkjaer, Arkadiusz Nawrocki, Justyna Okarmus, Agnieszka Wlodarczyk, Eva K. Thygesen, Miklos Palkovits, Ferenc Gallyas, Martin R. Larsen, Hans Lassmann, Eirikur Benedikz, Trevor Owens, Asa F. Svenningsen, Zsolt Illes
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundThe cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentiall
Externí odkaz:
https://doaj.org/article/a2c04274028e4e74a0394ae4a70c3f2a
Autor:
Nanna Dreyer-Andersen, Ana Sofia Almeida, Pia Jensen, Morad Kamand, Justyna Okarmus, Tine Rosenberg, Stig Düring Friis, Alberto Martínez Serrano, Morten Blaabjerg, Bjarne Winther Kristensen, Troels Skrydstrup, Jan Bert Gramsbergen, Helena L A Vieira, Morten Meyer
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191207 (2018)
Exploratory studies using human fetal tissue have suggested that intrastriatal transplantation of dopaminergic neurons may become a future treatment for patients with Parkinson's disease. However, the use of human fetal tissue is compromised by ethic
Externí odkaz:
https://doaj.org/article/f954a8cfff114e9b8cbb04544d320bc9
Autor:
Justyna Okarmus, Jette Bach Agergaard, Tina Stummann, Henriette Haukedal, Malene Ambjørn, Kristine Freude, Karina Fog, Morten Meyer
Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by PARK2) and the ubiquitin-specific protease 30 (USP30) have both been reported to regulate ubiquitinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7913a53bc1f36a3493246e6b8693ba8
https://doi.org/10.21203/rs.3.rs-2356942/v1
https://doi.org/10.21203/rs.3.rs-2356942/v1
