Multicenter immunoassay validation of cerebrospinal fluid neurofilament light: a biomarker for neurodegeneration

Autor: Aleksandra Rutkowska, Charlotte E. Teunissen, Niels Kruse, Brian A. Lawlor, Marleen J.A. Koel-Simmelink, Henrik Zetterberg, Anne Marie Miller, Justyna M.C. Bahl, Sanna-Kaisa Herukka, Anders Skinningsrud, Maritta Siloaho, Brit Mollenhauer

Publikováno v: Miller, A M, Rutkowska, A, Bahl, J M, Herukka, S K, Koel-Simmelink, M J A, Kruse, N, Mollenhauer, B, Siloaho, M, Skinningsrud, A, Zetterberg, H, Teunissen, C E & Lawlor, B A 2016, ' Multicenter immunoassay validation of cerebrospinal fluid neurofilament light : A biomarker for neurodegeneration ', Bioanalysis, vol. 8, no. 21, pp. 2243-2254 . https://doi.org/10.4155/bio-2016-0114
Bioanalysis, 8(21), 2243-2254. Future Science

Aim: Neurofilament light (NfL) chain, a putative cerebrospinal fluid biomarker, can support neurodegenerative disease diagnosis and indicate disease severity and prognosis. Universal validation protocols when used to measure biomarkers can reduce pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf84ceb3bbc2464f221ff22df165dca8
https://doi.org/10.4155/bio-2016-0114

Important options available - from start to finish - for translating proteomics results to clinical chemistry

Autor: Lars Melholt Rasmussen, Justyna M.C. Bahl, Niels H. H. Heegaard, Ole Østergaard, Hans Christian Beck, Martin Overgaard, Martin R. Larsen

Publikováno v: Heegaard, N H H, Ostergaard, O, Bahl, J M C, Overgaard, M, Beck, H C, Rasmussen, L M & Larsen, M R 2015, ' Important options available-from start to finish-for translating proteomics results to clinical chemistry ', Proteomics-Clinical Applications, vol. 9, no. 1-2, pp. 235-252 . https://doi.org/10.1002/prca.201400137

In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9f151a3de92b0fb05992d3d49b1cb4
https://doi.org/10.1002/prca.201400137

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

Autor: Lars Hemmingsen, Jeppe T. Pedersen, Kaare Teilum, Nunilo Cremades, Serene W. Chen, Samuel Ness, Justyna M.C. Bahl, Niels H. H. Heegaard, Christian B. Borg, Christopher M. Dobson

Publikováno v: Pedersen, J T, Chen, S W, Borg, C B, Ness, S, Bahl, J M, Heegard, N H H, Dobson, C M, Hemmingsen, L B S, Cremades, N & Teilum, K 2016, ' Amyloid-β and α-synuclein decrease the level of metal-catalyzed reactive oxygen species by radical scavenging and redox silencing ', Journal of the American Chemical Society, vol. 138, no. 12, pp. 3966-3969 . https://doi.org/10.1021/jacs.5b13577
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pedersen, J T, Chen, S W, Borg, C B, Ness, S, Bahl, J M, Heegaard, N H H, Dobson, C M, Hemmingsen, L, Cremades, N & Teilum, K 2016, ' Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing ', American Chemical Society. Journal, vol. 138, no. 12, pp. 3966–3969 . https://doi.org/10.1021/jacs.5b13577
Journal of the American Chemical Society

4 pags, 3 figs. -- The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/jacs.5b13577
The formation of reactive oxygen species (ROS) is linked to the pathogenesis of neurodegenerative diseases. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c43446293645b65b14b22cbc0b723da
https://www.repository.cam.ac.uk/handle/1810/256567

A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment

Autor: P. St. George-Hyslop, Marianne Schwartz, Justyna M.C. Bahl, Mustafa Batbayli, Anne Nørremølle, Fusheng Chen, Jette Stokholm, Henning Laursen, Raphaëlle Pardossi-Piquard, Birgitte Bo Andersen, Niels H. H. Heegaard, Suzanne Granhøj Lindquist, Lis Hasholt, Jørgen E. Nielsen, Gunhild Waldemar

Publikováno v: European Journal of Neurology. 15:1135-1139

Background: Mutations in the Presenilin 2 gene (PSEN2) are rare causes of Alzheimer’s disease (AD). Pathogenic mutations in the genes associated with autosomal dominant inherited AD have been shown to alter processing of the amyloid precursor prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b8f487feffb04cae700abf6361040a7
https://doi.org/10.1111/j.1468-1331.2008.02256.x

Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study

Autor: Staffan Persson, Uroš Rot, Giovanni B. Frisoni, María Salud García-Ayllón, Hanne Struyfs, Inês Baldeiras, André Janeiro, Julia T. Tanassi, Davide Chiasserini, Andreja Emeršič, Norbert Zilka, Maria João Leitão, Eugeen Vanmechelen, Tormod Fladby, Luisella Bocchio Chiavetto, Henrik Zetterberg, Niels Kruse, Justyna M.C. Bahl, H. Bea Kuiperij, Javier Sáez-Valero, Madalena Martins, Branislav Kovacech, Erden Eren, Hanne M. Møllergård, Daniel Alcolea, Annika Öhrfelt, Alberto Lleó, Catarina R. Oliveira, Mafalda Matos, Marcel M. Verbeek, Lucilla Parnetti, Magda Tsolaki, Kaj Blennow, Brit Mollenhauer, Niels H. H. Heegaard, Elisabetta Capello, Flavio Nobili, Sebastiaan Engelborghs, Olymbia Gkatzima, Sermin Genc, Peggy Taylor

Publikováno v: Neurobiology of aging
Neurobiology of Aging, 36, 2587-96
NEUROBIOL AGING
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Neurobiology of Aging, 36, 9, pp. 2587-96
NEUROBIOLOGY OF AGING
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
Kruse, N, Persson, S, Alcolea, D, Bahl, J M C, Baldeiras, I, Capello, E, Chiasserini, D, Chiavetto, L B, Emersic, A, Engelborghs, S, Eren, E, Fladby, T, Frisoni, G, Garcia-Ayllon, M S, Genc, S, Gkatzima, O, Heegaard, N H H, Janeiro, A M, Kovacech, B, Kuiperij, H B, Leitao, M J, Lleo, A, Martins, M, Matos, M, Mollergard, H M, Nobili, F, Ohrfelt, A, Parnetti, L, de Oliveira, C R, Rot, U, Saez-Valero, J, Struyfs, H, Tanassi, J T, Taylor, P, Tsolaki, M, Vanmechelen, E, Verbeek, M M, Zilka, N, Blennow, K, Zetterberg, H & Mollenhauer, B 2015, ' Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study ', Neurobiology of Aging, vol. 36, no. 9, pp. 2587-2596 . https://doi.org/10.1016/j.neurobiolaging.2015.05.003
r-FISABIO. Repositorio Institucional de Producción Científica
Neurobiology of Aging, Vol. 36, No 9 (2015) pp. 2587-96
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

© 2015 Elsevier Inc. All rights reserved.
Decreased levels of alpha-synuclein (aSyn) in cerebrospinal fluid (CSF) in Parkinson's disease and related synucleinopathies have been reported, however, not consistently in all cross-sectional studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3cd9f0240aade316cff1d05d000041
https://hdl.handle.net/10067/1263120151162165141