Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Justyna Cholewa-Waclaw"'
Autor:
Henna Myllymäki, Lisa Kelly, Abigail M. Elliot, Roderick N. Carter, Jeanette Astorga Johansson, Kai Yee Chang, Justyna Cholewa-Waclaw, Nicholas M. Morton, Yi Feng
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-9 (2024)
Abstract Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2]. Since then, the ‘Warburg effect’ has been wi
Externí odkaz:
https://doaj.org/article/daa0ac19c6e64ad68f3e9b677fb8b6dd
Autor:
Luise A. Seeker, Nadine Bestard-Cuche, Sarah Jäkel, Nina-Lydia Kazakou, Sunniva M. K. Bøstrand, Laura J. Wagstaff, Justyna Cholewa-Waclaw, Alastair M. Kilpatrick, David Van Bruggen, Mukund Kabbe, Fabio Baldivia Pohl, Zahra Moslehi, Neil C. Henderson, Catalina A. Vallejos, Gioele La Manno, Goncalo Castelo-Branco, Anna Williams
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hy
Externí odkaz:
https://doaj.org/article/f29980c47b3d48f6bf0dc467b3b6f292
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009087 (2020)
MeCP2 is an abundant protein in mature nerve cells, where it binds to DNA sequences containing methylated cytosine. Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome (RTT), provoking intensive study of the underlying mo
Externí odkaz:
https://doaj.org/article/485f8eb9e2fa4392bbf0997d9ff3db56
Autor:
Martha V. Koerner, Kashyap Chhatbar, Shaun Webb, Justyna Cholewa-Waclaw, Jim Selfridge, Dina De Sousa, Bill Skarnes, Barry Rosen, Mark Thomas, Joanna Bottomley, Ramiro Ramirez-Solis, Christopher Lelliott, David J. Adams, Adrian Bird
Publikováno v:
Epigenomes, Vol 3, Iss 1, p 7 (2019)
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for transcripts that do not code fo
Externí odkaz:
https://doaj.org/article/36c594723aaf41e0a98ad45949e822cf
Autor:
Konstantina Skourti-Stathaki, Atlanta G. Cook, Cornelia G. Spruijt, Adrian Bird, Kashyap Chhatbar, Michiel Vermeulen, Justyna Cholewa-Waclaw, Grace Alston, Raphaël Pantier, Heng Yang Lee, Beatrice Alexander-Howden, Timo Quante, Jim Selfridge
Publikováno v:
Molecular Cell
Mol Cell
Pantier, R, Chhatbar, K, Quante, T, Skourti Stathaki, K, Cholewa-Waclaw, J, Alston, G, Alexander-Howden, B, Yang Lee, H, Cook, A G, Spruijt, C G, Vermeulen, M, Selfridge, J & Bird, A P 2021, ' SALL4 controls cell fate in response to DNA base composition ', Molecular Cell, vol. 81, no. 4, pp. 845-858 . https://doi.org/10.1016/j.molcel.2020.11.046
Molecular Cell, 81, 845-858
Molecular Cell, 81, 4, pp. 845-858
Mol Cell
Pantier, R, Chhatbar, K, Quante, T, Skourti Stathaki, K, Cholewa-Waclaw, J, Alston, G, Alexander-Howden, B, Yang Lee, H, Cook, A G, Spruijt, C G, Vermeulen, M, Selfridge, J & Bird, A P 2021, ' SALL4 controls cell fate in response to DNA base composition ', Molecular Cell, vol. 81, no. 4, pp. 845-858 . https://doi.org/10.1016/j.molcel.2020.11.046
Molecular Cell, 81, 845-858
Molecular Cell, 81, 4, pp. 845-858
Summary Mammalian genomes contain long domains with distinct average compositions of A/T versus G/C base pairs. In a screen for proteins that might interpret base composition by binding to AT-rich motifs, we identified the stem cell factor SALL4, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62f4352809c1c1e2d3baac9b235017a
https://doi.org/10.1016/j.molcel.2020.11.046
https://doi.org/10.1016/j.molcel.2020.11.046
Autor:
Jim Selfridge, Joanna Bottomley, Adrian Bird, Ramires-Solis R, Lelliott C, Martha V. Koerner, Skarnes B, Barry Rosen, Mark G. Thomas, David J. Adams, De Sousa D, Shaun Webb, Kashyap Chhatbar, Justyna Cholewa-Waclaw
Publikováno v:
Koerner, M, Chhatbar, K, Webb, S, Cholewa-Waclaw, J, Selfridge, J, De Sousa, D, Skarnes, B, Rosen, B, Thomas, M, Bottomley, J, Ramires-Solis, R, Lelliott, C, Adams, D & Bird, A 2019, ' An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development ', Epigenomes, vol. 3, no. 1 . https://doi.org/10.3390/epigenomes3010007
Epigenomes, Vol 3, Iss 1, p 7 (2019)
Epigenomes
Volume 3
Issue 1
Epigenomes, Vol 3, Iss 1, p 7 (2019)
Epigenomes
Volume 3
Issue 1
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for transcripts that do not code fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cfaebb49d569b22323aaf7d9214288
https://www.pure.ed.ac.uk/ws/files/81454413/An_Orphan_CpG_PUB_OA_CC_BY_epigenomes_03_00007.pdf
https://www.pure.ed.ac.uk/ws/files/81454413/An_Orphan_CpG_PUB_OA_CC_BY_epigenomes_03_00007.pdf
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 10, p e1009087 (2020)
Chhatbar, K, Cholewa-Waclaw, J, Shah, R, Bird, A & Sanguinetti, G 2020, ' Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing ', PLoS Genetics, vol. 16, no. 10, e1009087 . https://doi.org/10.1371/journal.pgen.1009087
PLoS Genetics, Vol 16, Iss 10, p e1009087 (2020)
Chhatbar, K, Cholewa-Waclaw, J, Shah, R, Bird, A & Sanguinetti, G 2020, ' Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing ', PLoS Genetics, vol. 16, no. 10, e1009087 . https://doi.org/10.1371/journal.pgen.1009087
MeCP2 is an abundant protein in mature nerve cells, where it binds to DNA sequences containing methylated cytosine. Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome (RTT), provoking intensive study of the underlying mo
Publikováno v:
Waclaw, B, Cholewa-Waclaw, J & Greulich, P 2019, ' Totally asymmetric exclusion process with site-wise dynamic disorder ', Journal of Physics A: Mathematical and Theoretical . https://doi.org/10.1088/1751-8121/aafb8a
We propose an extension of the totally asymmetric simple exclusion process (TASEP) in which particles hopping along a lattice can be blocked by obstacles that dynamically attach/detach from lattice sites. The model can be thought as TASEP with site-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3884f0cc4750e6bcd65f959ae80ca6f9
http://arxiv.org/abs/1809.05441
http://arxiv.org/abs/1809.05441
Autor:
Shaun Webb, Kashyap Chhatbar, Bartlomiej Waclaw, Bernard Ramsahoye, Miao Yu, Justyna Cholewa-Waclaw, Ruth Shah, Oliver Pusch, Adrian Bird, Philip Greulich
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Cholewa-Waclaw, J, Shah, R, Webb, S, Chhatbar, K, Ramsahoye, B, Pusch, O, Yu, M, Greulich, P, Waclaw, B & Bird, A P 2019, ' Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic ', Proceedings of the National Academy of Sciences, vol. 116, no. 30, pp. 14995-15000 . https://doi.org/10.1073/pnas.1903549116
Cholewa-Waclaw, J, Shah, R, Webb, S, Chhatbar, K, Ramsahoye, B, Pusch, O, Yu, M, Greulich, P, Waclaw, B & Bird, A P 2019, ' Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic ', Proceedings of the National Academy of Sciences, vol. 116, no. 30, pp. 14995-15000 . https://doi.org/10.1073/pnas.1903549116
Significance We introduce an interdisciplinary approach to understanding global modulation of gene expression in mammalian cells. Conventional transcription factors target a limited subset of genes, whereas global modulators bind the genome broadly.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef4156f6c8804bad8fc11e3b00c8a20
Autor:
Julien Bouvier, Carmen Birchmeier, Gilles Fortin, Marie-Pierre Morin-Surun, Jean Champagnat, Luis R. Hernandez-Miranda, Justyna Cholewa-Waclaw, Pierre-Louis Ruffault, Niccolò Zampieri, Andrew J. Murray, Jean-François Brunet, Elodie Ey
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩
International audience; Vocalization in young mice is an innate response to isolation or mechanical stimulation. Neuronal circuits that control vocalization and breathing overlap and rely on motor neurons that innervate laryngeal and expiratory muscl