Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Justyna Brasuń"'
Autor:
Alicja Lisowska, Paulina Świątek, Filip Dębicki, Agnieszka Lewińska, Aleksandra Marciniak, Lorenzo Pacini, Anna Maria Papini, Justyna Brasuń
Publikováno v:
Molecules, Vol 29, Iss 10, p 2197 (2024)
Bicyclic peptides have attracted the interest of pharmaceutical companies because of their remarkable properties, putting them on a new path in medicine. Their conformational rigidity improves proteolytic stability and leads to rapid penetration into
Externí odkaz:
https://doaj.org/article/b938540ae50c4709a5a5757af4698483
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6458 (2021)
In this paper, we present studies on the influence of the disulfide bridge on the copper (II) ions’ binding abilities by the cyclic His4-peptide. The studied ligand HKHPHRHC-S-S-C consists of nine amino acids. The cyclic structure was obtained thro
Externí odkaz:
https://doaj.org/article/5cac347750754ad7a522d3e0a1d3816d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6628 (2021)
In this paper, we present findings from studying the interaction of copper(II) ions with the His2-cyclopentapeptide and the role of proline used for the purpose of potentiometric titration and UV-Vis, CD and EPR spectroscopic measurements. Experiment
Externí odkaz:
https://doaj.org/article/f005085a1c7647a399b833ad23e9aaa0
Autor:
Paweł Lenartowicz, Mateusz Psurski, Aleksandra Kotynia, Aleksandra Pieniężna, Monika Cuprych, Klaudia Poniatowska, Justyna Brasuń, Paweł Kafarski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2168 (2021)
Background: Dehydropeptides are analogs of peptides containing at least one conjugate double bond between α,β-carbon atoms. Its presence provides unique structural properties and reaction centre for chemical modification. In this study, the series
Externí odkaz:
https://doaj.org/article/443fa0d2bf30442bb2e1982e43e20d9e
Publikováno v:
Dalton Transactions. 51:13368-13375
There is growing interest in bicyclic peptides among scientists. This group of compounds has more advantageous properties than monocyclic ligands and their application in medicine and biological sciences is possible. It is known that sometimes the pr
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8794 (2020)
Somatostatin analogues are useful pharmaceuticals in peptide receptor radionuclide therapy. In previous studies, we analyzed a new bicyclic somatostatin analogue (BCS) in connection with Cu(II) ions. Two characteristic sites were present in the pepti
Externí odkaz:
https://doaj.org/article/c8c0fe9103494789ab419ea9d77ebc15
The Analysis of the Structural Aspects of Cu(II) Binding by Cyclic His/Asp-Analogues of Somatostatin
Publikováno v:
International Journal of Peptide Research and Therapeutics. 26:969-977
Two new somatostatin analogs with a characteristic part of the sequence in their structures, -c(Cys-Phe-Trp-Lys-Thr-Cys)-, were synthesized and analyzed in terms of their coordination abilities with copper(II) ions. Cyclic peptides analyzed in our pr
Autor:
Łukasz Szyrwiel, Paweł Tokarz, László Wojnárovits, Wolfgang Caliebe, Zbigniew Szewczuk, Krisztina J. Kovács, Vadim Murzin, Mari Shimura, József S. Pap, Justyna Brasuń, Inna Szekacs, Aneta Paluch, Robert Horvath, Tünde Tóth, Adam Kubas
Publikováno v:
Chemico-Biological Interactions. 306:78-88
SALEN- and SALAN-based complexes with catalytically active metal centers are very promising small molecules to be utilized as part of antioxidant therapies. Here we discuss a modified SALAN-type molecule armed with two phosphonate groups that signifi
Publikováno v:
Journal of Coordination Chemistry. 72:1592-1602
The hypothesis connecting dyshomeostasis of selected metal ions in the brain with increased probability of the development of severe neurodegenerative diseases is gaining increasing attention. The mechanisms of metal toxicity can be studied using dif
Autor:
Bartosz Setner, Łukasz Szczukowski, Zbigniew Szewczuk, Dávid Lukács, Justyna Brasuń, Tetsuya Ishikawa, József S. Pap, Łukasz Szyrwiel
Publikováno v:
Catalysis Communications. 122:5-9
A multiply branched peptide, H-Gly-Dap(H-Gly)-Dap(H-Gly-Dap(H-Gly))-Gly-NH2 (Dap = L-2,3-diaminopropionic acid) has been designed to furnish multi-Cu2+ centers exhibiting electrocatalytic activity in water oxidation. Each branching moiety serves as b