Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Justyna A. Glegola"'
Autor:
Marie-Therese Rached, Steven J. Millership, Silvia M.A. Pedroni, Agharul I. Choudhury, Ana S.H. Costa, Darran G. Hardy, Justyna A. Glegola, Elaine E. Irvine, Colin Selman, Megan C. Woodberry, Vijay K. Yadav, Sanjay Khadayate, Antonio Vidal-Puig, Samuel Virtue, Christian Frezza, Dominic J. Withers
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 38-50 (2019)
Objective: Sympathetic nervous system and immune cell interactions play key roles in the regulation of metabolism. For example, recent convergent studies have shown that macrophages regulate obesity through brown adipose tissue (BAT) activation and b
Externí odkaz:
https://doaj.org/article/5803aa224a3943529081e8fdb36d8b37
Autor:
Paulius Viskaitis, Elaine E. Irvine, Mark A. Smith, Agharul I. Choudhury, Elisa Alvarez-Curto, Justyna A. Glegola, Darran G. Hardy, Silvia M.A. Pedroni, Maria R. Paiva Pessoa, Anushka B.P. Fernando, Loukia Katsouri, Alessandro Sardini, Mark A. Ungless, Graeme Milligan, Dominic J. Withers
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3559-3572 (2017)
Summary: Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in
Externí odkaz:
https://doaj.org/article/81e3234bc5b2496cb0686f51772bf269
Autor:
Michelle Kokkinou, Sridhar Natesan, Kyoko Tossell, Seth C. Hopkins, David R. Bonsall, Dominic J. Withers, Mark A. Ungless, Eleanor J. Paul, Nina Dedic, Mark A. Smith, Elaine E. Irvine, Justyna A. Glegola, Oliver D. Howes, Lisa Wells, Sanjay Khadayate, Mattia Veronese
Publikováno v:
Molecular Psychiatry
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunctio
Autor:
Justyna A. Glegola, Leontien Bosch, Ilaria Meloni, Nicholas D. Mazarakis, Francesca Hearn-Yeates, Ioanna Eleftheriadou, Alessandra Renieri, Yunan Gao, Maria Kinali, Elaine E. Irvine, Aleksandra Czerniak, Leah Murdoch, Carlos Jiménez Naranjo
Publikováno v:
Brain
Cyclin-dependent kinase-like 5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene. It predominantly affects females who typically present with severe early epileptic enceph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d498d419960eae616a56d8af1fe4a1a
http://hdl.handle.net/10044/1/77254
http://hdl.handle.net/10044/1/77254
Autor:
Agharul I. Choudhury, Hanns Ulrich Zeilhofer, Mark A. Smith, paulius viskaitis, pedro caldas custodio de campos silva, Sanjay Khadayate, Justyna A. Glegola, Elaine E. Irvine, Dominic J. Withers
Publikováno v:
The Journal of Clinical Investigation
The Journal of Clinical Investigation, 130 (1)
The Journal of Clinical Investigation, 130 (1)
Arcuate nucleus agouti–related peptide (AgRP) neurons play a central role in feeding and are under complex regulation by both homeostatic hormonal and nutrient signals and hypothalamic neuronal pathways. Feeding may also be influenced by environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f3ce29f7a6bc52e7c65f9a16043be7
http://hdl.handle.net/10044/1/73651
http://hdl.handle.net/10044/1/73651
Autor:
Nina Dedic, Mark A. Ungless, Mattia Veronese, Oliver D. Howes, Sanjay Khadayate, Seth C. Hopkins, Eleanor J. Paul, David R. Bonsall, Kyoko Tossell, Dominic J. Withers, Justyna A. Glegola, Sridhar Natesan, Lisa Wells, Elaine E. Irvine, Mark Smith, Michelle Kokkinou
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. However, the mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acd1787cf4257cef5540a828d54f499
https://doi.org/10.1101/748665
https://doi.org/10.1101/748665
Autor:
Elaine E. Irvine, Danijela Heide, Juan Pedro Martinez-Barbera, Antoni Olona, Dominic J. Withers, Joaquim Pombo, Saba Manshaei, Suchira Gallage, Daniel Dauch, Nicolás Herranz, Gopuraja Dharmalingam, Romain Guiho, Bin Sun, Lars Zender, Justyna A. Glegola, Katharina Wolter, Santiago Vernia, Ana Guerrero, Wagner, Mathias Heikenwalder, Andrew J. Innes, Jesús Gil, Anthony G. Uren, Jule Harbig, Jacques Behmoaras, Jodie Birch
Publikováno v:
Nature Metabolism
Nature metabolism
Nature metabolism
Senescence is a cellular stress response that results in the stable arrest of old, damaged or pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also exacerbate tumorigenesis through the secretion of proinflammatory facto
Autor:
Eleanor Sandhu, Elaine E. Irvine, Anushka B. P. Fernando, Oliver D. Howes, Kyoko Tossell, Mark A. Ungless, Dominic J. Withers, Justyna A. Glegola, Mark A. Smith, Michelle Kokkinou
Publikováno v:
eNeuro
Salt intake is an essential dietary requirement, but excessive consumption is implicated in hypertension and associated conditions. Little is known about the neural circuit mechanisms that control motivation to consume salt, although the midbrain dop