Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Justyna, Godyń"'
Autor:
Izabella Góral, Tomasz Wichur, Emilia Sługocka, Justyna Godyń, Natalia Szałaj, Paula Zaręba, Monika Głuch-Lutwin, Barbara Mordyl, Dawid Panek, Anna Więckowska
Publikováno v:
Molecules, Vol 29, Iss 11, p 2616 (2024)
GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer’s disease due to their involvement in the misfolding and accumulation of amyloid β (Aβ) and tau proteins, as well as inflammatory processes. Among these kinases
Externí odkaz:
https://doaj.org/article/d794b4a155cb4c9da646e809bc8a5781
Autor:
Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 675 (2023)
This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets. We evaluated their potential against two targets viz., inhibition of MDA-MB-231, a
Externí odkaz:
https://doaj.org/article/b9fb5d11a66f4497888c7bc071bb662d
Autor:
Dorota Łażewska, Maria Kaleta, Paula Zaręba, Justyna Godyń, Mariam Dubiel, Ewelina Honkisz-Orzechowska, Agata Doroz-Płonka, Anna Więckowska, Holger Stark, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 28, Iss 5, p 2349 (2023)
Alzheimer’s disease (AD) is a neurodegenerative disorder, for which there is no effective cure. Current drugs only slow down the course of the disease, and, therefore, there is an urgent need to find effective therapies that not only treat, but als
Externí odkaz:
https://doaj.org/article/e4f4f258d08342fc9d582fd5b050fa49
Autor:
Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://doaj.org/article/8664353705ab4c3dbfa4416d81bfa9d5
Autor:
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Publikováno v:
Molecules, Vol 28, Iss 1, p 238 (2022)
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a nove
Externí odkaz:
https://doaj.org/article/2481fe283dea45f89bc7efb49683033f
Autor:
Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 26, Iss 12, p 3580 (2021)
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but
Externí odkaz:
https://doaj.org/article/d9e7c3fbce1d4dee984dbfe75cd18352
Autor:
Jakub Jończyk, Justyna Godyń, Ewelina Stawarska, Beata Morak-Młodawska, Małgorzata Jeleń, Krystian Pluta, Barbara Malawska
Publikováno v:
Molecules, Vol 25, Iss 11, p 2604 (2020)
The inverse correlation observed between Alzheimer’s disease (AD) and cancer has prompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that possess anticancer properties. With the use of in silico and in vitro scre
Externí odkaz:
https://doaj.org/article/1a61fca694ef43b1a61990b7f12842f8
Autor:
Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowska
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9443
Neurodegeneration leading to Alzheimer’s disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8815f709e03fedba13439d619bcb7fcc
Autor:
Krzysztof, Więckowski, Natalia, Szałaj, Beata, Gryzło, Tomasz, Wichur, Izabella, Góral, Emilia, Sługocka, Joanna, Sniecikowska, Gniewomir, Latacz, Agata, Siwek, Justyna, Godyń, Adam, Bucki, Marcin, Kołaczkowski, Anna, Więckowska
Publikováno v:
International journal of molecular sciences. 23(16)
Neurodegeneration leading to Alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bd4358802443ef327e1978a76a7da5a
https://pubmed.ncbi.nlm.nih.gov/36012707
https://pubmed.ncbi.nlm.nih.gov/36012707
Autor:
Anja Pišlar, Anna Więckowska, Barbara Malawska, Paula Zaręba, Raimon Sabaté, Dawid Panek, Jakub Jończyk, Tomasz Wichur, Natalia Szałaj, Anna Pasieka, Krzysztof Więckowski, Justyna Godyń, Marek Bajda
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1944-1952 (2020)
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands –
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605fad8a83670327e0c22e4f705ac0bf
https://doi.org/10.1080/14756366.2020.1835882
https://doi.org/10.1080/14756366.2020.1835882