Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response

Autor: Tia M Morgan, Joe S. Mymryk, Amélie Fradet-Turcotte, Elise Biquand, Elise G. Lavoie, Sophie Blanchet, Justine Sitz, Maxime Galloy, Julien Dessapt, Steven F. Gameiro, Cary A. Moody, Brandon C Smith, Andréanne Blondeau

Publikováno v: Proceedings of the National Academy of Sciences. 116:19552-19562

High-risk human papillomaviruses (HR-HPVs) promote cervical cancer as well as a subset of anogenital and head and neck cancers. Due to their limited coding capacity, HPVs hijack the host cell’s DNA replication and repair machineries to replicate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff3723cff45caf0a0d4d7b7d74df99b
https://doi.org/10.1073/pnas.1906102116

N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy

Autor: Gilles Guichard, Stéphane Bellemin-Laponnaz, Marion Decossas, Olivier Lambert, Sylvie Fournel, Riccardo Rubbiani, Georges Dahm, Edith Chardon, Benoît Frisch, Gilles Gasser, May Wantz, Justine Sitz, Neila Chekkat

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2016, 27 (8), pp.1942-1948. ⟨10.1021/acs.bioconjchem.6b00320⟩
BASE-Bielefeld Academic Search Engine

The current interest for platinum N-heterocyclic carbene complexes in cancer research stems from their impressive toxicity reported against a range of different human cancer cells. To date, the demonstration of their in vivo efficacy relative to that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb4ce7dc9576bec39b660fb049dcf56
https://hal.archives-ouvertes.fr/hal-02185416