Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Justine M. Grixti"'
Autor:
Chrispian W. Theron, J. Enrique Salcedo-Sora, Justine M. Grixti, Iben Møller-Hansen, Irina Borodina, Douglas B. Kell
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 938 (2024)
Clozapine is an antipsychotic drug whose accumulation in white cells can sometimes prove toxic; understanding the transporters and alleles responsible is thus highly desirable. We used a strategy in which a yeast (Saccharomyces cerevisiae) CRISPR-Cas
Externí odkaz:
https://doaj.org/article/032f87167c0842f9ba6f31b544fdf257
Autor:
Justine M. Grixti, Duncan Ayers
Publikováno v:
Non-coding RNA Research, Vol 5, Iss 2, Pp 77-82 (2020)
The central dogma of molecular biology, developed from the study of simple organisms such as Escherichia coli, has up until recently been that RNA functions mainly as an information intermediate between a DNA sequence (gene), localized in the cell nu
Externí odkaz:
https://doaj.org/article/b9c76b5949124fed8ad0734a1f4357c8
Publikováno v:
Non-Coding RNA, Vol 7, Iss 2, p 27 (2021)
Up until recently, it was believed that pharmaceutical drugs and their metabolites enter into the cell to gain access to their targets via simple diffusion across the hydrophobic lipid cellular membrane, at a rate which is based on their lipophilicit
Externí odkaz:
https://doaj.org/article/de98bfd6af994a5590e9cee6cad80f20
Autor:
Anatolii Sorokin, Royston Goodacre, Joseph M Taylor, Ivayla Roberts, Marina Wright Muelas, Douglas B. Kell, Andrew S. Davison, Justine M. Grixti, Yun Xu, Nigel Gotts
Publikováno v:
Metabolomics
Roberts, I, Wright Muelas, M, Taylor, J M, Davison, A S, Xu, Y, Grixti, J M, Gotts, N, Sorokin, A, Goodacre, R & Kell, D B 2022, ' Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome ', Metabolomics, vol. 18, 6 . https://doi.org/10.1007/s11306-021-01859-3
Roberts, I, Wright Muelas, M, Taylor, J M, Davison, A S, Xu, Y, Grixti, J M, Gotts, N, Sorokin, A, Goodacre, R & Kell, D B 2022, ' Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome ', Metabolomics, vol. 18, 6 . https://doi.org/10.1007/s11306-021-01859-3
Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of viral nucleic acid sequences. Properties of the host response are not measured but are key in determining outcome. Although metabolic profiles are well suited to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffcd954fe887ac5ac8d2154f7c61d71
https://doi.org/10.1007/s11306-021-01859-3
https://doi.org/10.1007/s11306-021-01859-3
Publikováno v:
Non-Coding RNA
Non-Coding RNA, Vol 7, Iss 27, p 27 (2021)
Non-Coding RNA, Vol 7, Iss 27, p 27 (2021)
Up until recently, it was believed that pharmaceutical drugs and their metabolites enter into the cell to gain access to their targets via simple diffusion across the hydrophobic lipid cellular membrane, at a rate which is based on their lipophilicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd4ed010fab1de0a207c69adf687010
https://doi.org/10.3390/ncrna7020027
https://doi.org/10.3390/ncrna7020027
Publikováno v:
Frontiers in Pharmacology
The transport of drug molecules is mainly determined by the distribution of influx and efflux transporters for which they are substrates. To enable tissue targeting, we sought to develop the idea that we might affect the transporter-mediated disposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::199dcd8da8278a8dd8f8cffa69f2bce6
https://pubmed.ncbi.nlm.nih.gov/28396636
https://pubmed.ncbi.nlm.nih.gov/28396636