Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Justine J. Jacobi"'
Autor:
Kanita A. Chaudhry, Justine J. Jacobi, Bryan M. Gillard, Ellen Karasik, Jeffrey C. Martin, Tatiane da Silva Fernandes, Edward Hurley, Maria Laura Feltri, Kristopher M. Attwood, Clare J. Twist, Dominic J. Smiraglia, Mark D. Long, Anna Bianchi-Smiraglia
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108303- (2023)
Summary: Neuroblastoma is the most common extracranial solid tumor in children. MYCN amplification is detected in almost half of high-risk cases and is associated with poorly differentiated tumors, poor patient prognosis and poor response to therapy,
Externí odkaz:
https://doaj.org/article/0f7c74a86b7e44b09089d3f48142cad7
Autor:
Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero, Dominic J. Smiraglia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP s
Externí odkaz:
https://doaj.org/article/e67ec780a1554759a4b84c3b9ee77ce5
Autor:
Mark D. Long, Justine J. Jacobi, Prashant K. Singh, Gerard Llimos, Sajad A. Wani, Aryn M. Rowsam, Spencer R. Rosario, Marlous Hoogstraat, Simon Linder, Jason Kirk, Hayley C. Affronti, Andries Bergman, Wilbert Zwart, Moray J. Campbell, Dominic J. Smiraglia
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110109- (2021)
Summary: This study addresses the roles of nuclear receptor corepressor 2 (NCOR2) in prostate cancer (PC) progression in response to androgen deprivation therapy (ADT). Reduced NCOR2 expression significantly associates with shorter disease-free survi
Externí odkaz:
https://doaj.org/article/4a042eabf97c4a9c95ff32cac4f01811
Autor:
Dominic J. Smiraglia, Aryn M. Rowsam, Hayley C. Affronti, Mark D. Long, Justine J. Jacobi, Spencer R. Rosario
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209e5f4664386f07d9731bc83480db09
https://doi.org/10.1158/1541-7786.22528133.v1
https://doi.org/10.1158/1541-7786.22528133.v1
Autor:
Dominic J. Smiraglia, Aryn M. Rowsam, Hayley C. Affronti, Mark D. Long, Justine J. Jacobi, Spencer R. Rosario
Identifying and leveraging unique points of metabolic dysregulation in different disease settings is vital for safe and effective incorporation of metabolism-targeted therapies in the clinic. In addition, it has been shown identification of master me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e86c2f0515a6a5b4c9b30b029c96a03
https://doi.org/10.1158/1541-7786.c.6545624.v1
https://doi.org/10.1158/1541-7786.c.6545624.v1
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Autor:
Dominic J. Smiraglia, Aryn M. Rowsam, Hayley C. Affronti, Mark D. Long, Justine J. Jacobi, Spencer R. Rosario
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0107944951712238f608c0fc9069d4af
https://doi.org/10.1158/1541-7786.22528109.v1
https://doi.org/10.1158/1541-7786.22528109.v1
Autor:
Spencer R. Rosario, Justine J. Jacobi, Mark D. Long, Hayley C. Affronti, Aryn M. Rowsam, Dominic J. Smiraglia
Publikováno v:
Mol Cancer Res
Identifying and leveraging unique points of metabolic dysregulation in different disease settings is vital for safe and effective incorporation of metabolism-targeted therapies in the clinic. In addition, it has been shown identification of master me
Autor:
Barbara A. Foster, Robert A. Casero, Mikhail A. Nikiforov, Anna Bianchi-Smiraglia, Gissou Azabdaftari, Mark D. Long, Hayley C. Affronti, Roberto Pili, Ellen Karasik, Justine J. Jacobi, Anthony J. Pellerite, Michael T. Moser, Kristopher Attwood, Dominic J. Smiraglia, Bryan Gillard, John Wilton, Aryn M. Rowsam, James G. Phillips, Christoph S. Boerlin, Spencer Rosario
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Prostatic luminal epithelial cells secrete high levels of acetylated polyamines into the prostatic lumen, sensitizing them to perturbations of connected metabolic pathways. Enhanced flux is driven by spermidine/spermine N1-acetyltransferase (SSAT) ac
Autor:
Aryn M. Rowsam, Moray J. Campbell, Spencer Rosario, Dominic J. Smiraglia, Hayley C. Affronti, Prashant Singh, Gerard Llimos, Jason Kirk, Justine J. Jacobi, Mark D. Long
NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ddf90b4d9e399451d86782439e8b6fd
https://doi.org/10.1101/2020.07.02.182758
https://doi.org/10.1101/2020.07.02.182758
Autor:
Justine J. Jacobi, Derek L. Beahm
Publikováno v:
Biophysical Journal. 112:551a
Gap junction channels form aqueous pores connecting the cystolic compartments of two cells, allowing for the direct transfer of ions, metabolites, and signaling molecules between cells. A single gap junction channel consists of two docked hemichannel