Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Justine J. Cunningham"'
Autor:
Mehdi Gasmi, Eugene P. Brandon, Christopher D. Herzog, Alistair Wilson, Kathie M. Bishop, Eva K. Hofer, Justine J. Cunningham, Marie A. Printz, Jeffrey H. Kordower, Raymond T. Bartus
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 1, Pp 67-76 (2007)
Neurturin (NTN) is a neurotrophic factor with known potential to protect and restore the function of dopaminergic substantia nigra neurons whose degeneration has been most closely linked to the major motor deficits in Parkinson’s disease (PD). CERE
Externí odkaz:
https://doaj.org/article/28de73540213461089795622b0b5b4cb
Autor:
Justine J Cunningham, Mike Richardson, Kuniko Kadoya, Nora G. Smart, Melissa K. Carpenter, Susan Eliazer, Holly Y. Young, Emmanuel E. Baetge, Anne G. Bang, Olivia Kelly, Evert Kroon, Alan D. Agulnick, Laura Martinson, Kevin A. D'Amour
Publikováno v:
Nature Biotechnology. 26:443-452
Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from human embryonic stem (hES) cells efficiently generates glucose-responsive endocrine cells af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c2264a079324d8e12ea8bed61c0ef3
https://doi.org/10.1038/nbt1393
https://doi.org/10.1038/nbt1393
Autor:
Eva K. Hofer, Alistair Wilson, Kathie M. Bishop, Mehdi Gasmi, Jeffrey H. Kordower, Marie A. Printz, Justine J Cunningham, Raymond T. Bartus, Christopher D. Herzog, Eugene P. Brandon
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 1, Pp 67-76 (2007)
Neurturin (NTN) is a neurotrophic factor with known potential to protect and restore the function of dopaminergic substantia nigra neurons whose degeneration has been most closely linked to the major motor deficits in Parkinson’s disease (PD). CERE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8ca29f063a97d6cd7313f7bacde1d7
https://doi.org/10.1016/j.nbd.2007.04.003
https://doi.org/10.1016/j.nbd.2007.04.003
Autor:
Robyn N. McKeller, Nikita Warner, Stephen X. Skapek, Frederique Zindy, Jennifer L. Fowler, Richard J. Smeyne, Justine J. Cunningham
Publikováno v:
Proceedings of the National Academy of Sciences. 99:3848-3853
A key tumor suppressor mechanism that is disrupted frequently in human cancer involves the ARF and p53 genes. In mouse fibroblasts, the Arf gene product responds to abnormal mitogenic signals to activate p53 and trigger either cell cycle arrest or ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4765c4ce16969a85862d775eb9a7a89b
https://doi.org/10.1073/pnas.052484199
https://doi.org/10.1073/pnas.052484199
Publikováno v:
Journal of Receptors and Signal Transduction. 20:87-103
In adult animals, signaling through the leptin receptor (OB-R) has been shown to play a critical role in fat metabolism. However, it is not known when these receptors are first expressed and what their role may be during embryonic development. To dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960755dbfe34820bbf3699cf35fe7cf4
https://doi.org/10.3109/10799890009150039
https://doi.org/10.3109/10799890009150039
Autor:
Richard J. Smeyne, Justine J. Cunningham, Frederique Zindy, Sachin Jogal, Martine F. Roussel, Charles J. Sherr
Publikováno v:
Proceedings of the National Academy of Sciences. 96:13462-13467
Development of the central nervous system requires proliferation of neuronal and glial cell precursors followed by their subsequent differentiation in a highly coordinated manner. The timing of neuronal cell cycle exit and differentiation is likely t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd1d5a0b3048e3ea2968ded355d3a65
https://doi.org/10.1073/pnas.96.23.13462
https://doi.org/10.1073/pnas.96.23.13462
Autor:
Vikram Arora, Eugene P. Brandon, Joy A. Cavagnaro, Anu V. Connor, Justine J. Cunningham, Maggie Dempster, Christina de Zafra, Thomas R. Gelzleichter, Wendy G. Halpern, Danuta J. Herzyk, Beth Hinkle, Inge A. Ivens, Amy Kim, Donna W. Lee, Timothy K. MacLachlan, Melinda Marian, Barbara Mounho-Zamora, Padma Kumar Narayanan, Rania Nasis, Deborah L. Novicki, Lisa M. Plitnick, Rafael Ponce, Rodney A. Prell, Karen D. Price, Gautham K. Rao, Theresa Reynolds, Wolfgang Seghezzi, Marque D. Todd, Jayanthi J. Wolf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379a92313fc7c8b67b5e58857a6cb5f7
https://doi.org/10.1016/b978-0-12-394810-6.01002-9
https://doi.org/10.1016/b978-0-12-394810-6.01002-9
Human pluripotent stem cells (PSCs) have the potential to transform our understanding of cell and molecular biology and lead to the development of treatments for a wide array of diseases with unmet medical needs. But as with most novel biologics, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77a43682c37398759d27643b5b65df9
https://doi.org/10.1016/b978-0-12-394810-6.00015-0
https://doi.org/10.1016/b978-0-12-394810-6.00015-0
Publikováno v:
Nature Biotechnology, 30(9), 849-857. Nature Publishing Group
The potential for the formation of teratomas or other neoplasms is a major safety roadblock to clinical application of pluripotent stem cell therapies. Preclinical assessment of the risk of tumor formation in this context poses considerable scientifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5714e0dd589528bc87fae0a2029cf5b7
https://pubmed.ncbi.nlm.nih.gov/22965062
https://pubmed.ncbi.nlm.nih.gov/22965062
Autor:
Eugene P. Brandon, Justine J Cunningham, Mehdi Gasmi, Elias T. Ketchum, G Anthony Ramirez, Christopher D. Herzog, Raymond T. Bartus
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 15(1)
Glial cell line–derived neurotrophic factor (GDNF) or its naturally occurring analog, neurturin (NTN), can potentially improve the function and delay the rate of degeneration of dopaminergic neurons in Parkinson's disease (PD). However, their deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d30aa4692738b8f81bf6497023fbd0
https://pubmed.ncbi.nlm.nih.gov/17164776
https://pubmed.ncbi.nlm.nih.gov/17164776