Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Justine Badée"'
Autor:
Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 29-35 (2021)
On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry, and clinical research organ
Externí odkaz:
https://doaj.org/article/690f10a798a64e0ea88774b713cf9363
Autor:
Tamara D. Cabalu, Mengyao Li, Kenichi Umehara, Dermot F. McGinnity, Neil Parrott, Kunal S Taskar, Arian Emami Riedmaier, Micaela B Reddy, Hugues Chanteux, Martin E. Dowty, Justine Badée, Jialin Mao, Jayaprakasam Bolleddula, Loeckie de Zwart, Jessica Rehmel, Dwaipayan Mukherjee, Chandra Prakash, Niresh Hariparsad, Masakatsu Kotsuma, Diane Ramsden, Karthik Venkatakrishnan, Venkatesh Pilla Reddy, Kushal Shah
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:770-781
The International Consortium for Innovation and Quality (IQ) Physiologically Based Pharmacokinetic (PBPK) Modeling Induction Working Group (IWG) conducted a survey across participating companies around general strategies for PBPK modeling of inductio
Autor:
Johan Nicolaï, Pieter Annaert, Bianca D van Groen, Saskia N. de Wildt, Venkatesh Pilla Reddy, Catherijne A. J. Knibbe, Trevor N. Johnson, Andrés Olivares-Morales, Loeckie de Zwart, Justine Badée, Anne Smits
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 29-35 (2021)
CTS-Clinical and Translational Science, 14(1), 29-35. American Society for Clinical Pharmacology & Therapeutics
Clinical and Translational Science, 14(1), 29-35. Wiley-Blackwell Publishing Ltd
Clinical and Translational Science
Cts-Clinical and Translational Science, 14, 29-35
Cts-Clinical and Translational Science, 14, 1, pp. 29-35
CTS-Clinical and Translational Science, 14(1), 29-35. American Society for Clinical Pharmacology & Therapeutics
Clinical and Translational Science, 14(1), 29-35. Wiley-Blackwell Publishing Ltd
Clinical and Translational Science
Cts-Clinical and Translational Science, 14, 29-35
Cts-Clinical and Translational Science, 14, 1, pp. 29-35
On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry, and clinical research organ
Publikováno v:
Drug Metabolism and Disposition. 48:176-186
UDP-glucuronosyltransferase (UGT)1A4 and UGT2B10 are the human UGT isoforms most frequently involved in N-glucuronidation of drugs. UGT2B10 exhibits higher affinity than UGT1A4 for numerous substrates, making it potentially the more important enzyme
Publikováno v:
Drug Metabolism and Disposition. 47:124-134
UDP-glucuronosyltransferase (UGT)–mediated metabolism is possibly the most important conjugation reaction for marketed drugs. However, there are currently no generally accepted standard incubation conditions for UGT microsomal assays, and substanti
Autor:
E. van Peer, Pieter Annaert, A. C. Kuik, Karel Allegaert, S. Van Cruchten, Johan Nicolaï, SN de Wildt, L. De Schaepdrijver, Stephan Schmidt, Justine Badée, B. D. van Groen, Anne Smits
Publikováno v:
Pharmacological Reviews, 73, 2, pp. 597-678
Pharmacological Reviews, 73, 597-678
Pharmacological reviews
Pharmacological Reviews, 73(2), 597-678. American Society for Pharmacology and Experimental Therapeutics
Pharmacological Reviews, 73, 597-678
Pharmacological reviews
Pharmacological Reviews, 73(2), 597-678. American Society for Pharmacology and Experimental Therapeutics
The liver represents a major eliminating and detoxifying organ, determining exposure to endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug-metabolizing enzymes (DMEs) are key determinants of disposition, efficacy, an
Autor:
Stephen Fowler, Stephan Schmidt, Michael W.H. Coughtrie, Justine Badée, Abby C. Collier, Neil Parrott, Ryan H. Takahashi, Yuejian Liu, Peter I. Mackenzie
Publikováno v:
Journal of clinical pharmacologyReferences. 60(6)
Uridine diphosphate glucuronosyltransferases (UGTs) catalyze glucuronidation to facilitate systemic and local clearance of numerous chemicals and drugs. To investigate whether UGT expression is coregulated in human liver, we analyzed the protein expr
Autor:
Stephan Schmidt, Justine Badée, Abby C. Collier, Nahong Qiu, Neil Parrott, William F. Forrest, Stephen Fowler, Ryan H. Takahashi
Publikováno v:
The Journal of Clinical Pharmacology. 59
An understanding of the postnatal development of hepatic UDP-glucuronosyltransferase (UGT) enzymes is required for accurate prediction of the age-dependent changes in pharmacokinetics of many drugs used in children. However, the maturation rate of he
Autor:
Saskia N. de Wildt, Stephan Schmidt, Justine Badée, Abby C. Collier, Neil Parrott, Stephen Fowler
Publikováno v:
Clinical Pharmacokinetics, 58, 2, pp. 189-211
Clinical Pharmacokinetics, 58, 189-211
Clinical Pharmacokinetics, 58(2), 189-211. Adis
Clinical Pharmacokinetics, 58, 189-211
Clinical Pharmacokinetics, 58(2), 189-211. Adis
Item does not contain fulltext Limited understanding of drug pharmacokinetics in children is one of the major challenges in paediatric drug development. This is most critical in neonates and infants owing to rapid changes in physiological functions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092f5c41a96546eb1cdef59ab947cc51
https://hdl.handle.net/2066/203206
https://hdl.handle.net/2066/203206
Autor:
Nina Nauwelaerts, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi, Justine Badee, Frederico S. Martins, Anne Smits, Karel Allegaert, Thomas Bouillon, Pieter Annaert
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1469 (2023)
Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacok
Externí odkaz:
https://doaj.org/article/11f1b5bd790e446a9b2a3b6512657899