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pro vyhledávání: '"Justine A Melo"'
Autor:
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007038 (2017)
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding w
Externí odkaz:
https://doaj.org/article/944a8ce4a5f7455e8e44dd3caf07d459
Autor:
Justine A. Melo, Elizabeth A. Morton, Peter M. Douglas, Manjunatha Thondamal, Todd Lamitina, Andrew V. Samuelson, Adam Cornwell, Elliot W. Swartz, Joung Heon Kim, Beresford Crick, Ritika Das
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 10, p e1007038 (2017)
PLoS Genetics, Vol 13, Iss 10, p e1007038 (2017)
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding w
Publikováno v:
Molecular Cell. 30:267-276
Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has shown that two complexes independently sense DNA lesions: the kinase Mec1-Ddc2 and the PCNA-like 9-1-1 complex. To test whether colocalization of these components is sufficien
Autor:
David P. Toczyski, Stephanie K. Cheung, Julia A. Kaye, Moreshwar B. Vaze, Justine A. Melo, James E. Haber
Publikováno v:
Current Biology. 14(23):2096-2106
Background: Unrepaired DNA double-stranded breaks (DSBs) can result in the whole or partial loss of chromosomes. Previously, we showed that the ends of broken chromosomes remain associated. Here, we have examined the machinery that holds broken chrom
Publikováno v:
Genes & Development. 15:2809-2821
The Ddc1/Rad17/Mec3 complex and Rad24 are DNA damage checkpoint components with limited homology to replication factors PCNA and RF-C, respectively, suggesting that these factors promote checkpoint activation by “sensing” DNA damage directly. Mec
Publikováno v:
Mammalian Genome. 9:812-815
We report on the observation of sex-restricted, non-Mendelian inheritance over a region of mouse Chromosome (Chr) 11, occurring in the offspring of crosses between two commonly used Mus musculus-derived inbred strains, C57BL/6J and DBA/2J. In the sur
Publikováno v:
Nature Genetics. 13:147-153
Mice from various inbred strains consume alcoholic beverages at highly reproducible and strain-specific levels. While most mice consume alcohol in moderate amounts, C57BL/6J animals exhibit sustained oral ingestion of high levels of alcohol in the pr
Autor:
Justine A. Melo, Gary Ruvkun
Publikováno v:
Cell. 149(2)
SummaryThe nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities, including translation, respiration, and protein turnover, st
Publikováno v:
Genesdevelopment. 23(4)
Rictor is a component of the target of rapamycin complex 2 (TORC2). While TORC2 has been implicated in insulin and other growth factor signaling pathways, the key inputs and outputs of this kinase complex remain unknown. We identified mutations in th
Autor:
Justine A. Melo, David P. Toczyski
Publikováno v:
Current opinion in cell biology. 14(2)
Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having ho