Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Justine, Maltby"'
Autor:
Pär Karlsson, Angelica Quartino, Tjerk Bueters, Kristina Claeson-Bohnstedt, Tina Olsson, Gunilla Huledal, Erik Sparve, Maria Lüttgen, Johanna Fälting, Chi-Ming Lee, Robert Alexander, Björn Paulsson, Justine Maltby, Jonathan Paraskos
Publikováno v:
Clinical Pharmacology in Drug Development. 3:396-405
Modulating deposition of Aβ-containing plaques in the brain may be beneficial in treating Alzheimer's disease. β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors have been shown to reduce Aβ in plasma and CSF in healthy voluntee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a4513fc60fd6ec88e90fa34d9ed4581
https://doi.org/10.1002/cpdd.130
https://doi.org/10.1002/cpdd.130
Autor:
Samantha Budd Haeberlein, Alan R. Kugler, Tina Olsson, Robert C. Alexander, Naidong Ye, Muir Russell, Justine Maltby, Laura B. Rosen, Susanna Eketjäll, Ronald Goldwater, Gvido Cebers, Larry Ereshefsky, David Han
Publikováno v:
Journal of Alzheimer's disease : JAD. 55(3)
AZD3293 (LY3314814) is a promising new potentially disease-modifying BACE1 (β-secretase) inhibitor in Phase III clinical development for the treatment of Alzheimer's disease. Reported here are the first two Phase I studies: (1) a single ascending do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649776ea599109ee35a3b3a619d31886
https://pubmed.ncbi.nlm.nih.gov/27767991
https://pubmed.ncbi.nlm.nih.gov/27767991
Autor:
Stephen Delaney, Mark Biffen, David J. Keeling, Ajay Aggarwal, Maarten Kraan, John R. Bell, Sara Asimus, Justine Maltby
Publikováno v:
BMJ Open Respiratory Research
Background Many patients with asthma have a T-helper type 2 (Th2) driven inflammation of the lung, whereas toll-like receptor 7 (TLR7) agonists, by inducing type I interferons, inhibit Th2 responses. In man, oral or parenteral TLR7 agonists can induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb02011816e36d1bec084f4a20210a99
http://europepmc.org/articles/PMC4769423
http://europepmc.org/articles/PMC4769423
Autor:
Elaine Cadogan, Andrew Churg, Don D. Sin, Katherine R. Thain, Justine Maltby, S J Bolton, Philip Mallinder, Caroline Marshall, Joanne L. Wright, Matthew G. Soars, Steven Zhou
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 185:34-43
Inflammation and oxidative stress are linked to the deleterious effects of cigarette smoke in producing chronic obstructive pulmonary disease (COPD). Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80373d1a5763ef54b0653c443b6d613
https://doi.org/10.1164/rccm.201103-0468oc
https://doi.org/10.1164/rccm.201103-0468oc
Autor:
Katherine A. Vousden, Duncan James Cochrane, Alison Ward, Catriona L Buchanan, David C. Lowe, P.R. Mallinder, Donna K. Finch, A Midha, Robert I. Craggs, Roland Kolbeck, Matthew A. Sleeman, Justine Maltby, Caroline Grahames, Debbie V. Pattison, S. Cruwys
Publikováno v:
British Journal of Pharmacology. 162:480-490
BACKGROUND AND PURPOSE Interleukin-15 (IL-15) is important in the activation and proliferation of lymphocytic cell populations and is implicated in inflammatory disease. We report the characterization of a novel monoclonal antibody DISC0280 which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::735a38d3edafca20f2715ad66953e895
https://doi.org/10.1111/j.1476-5381.2010.01061.x
https://doi.org/10.1111/j.1476-5381.2010.01061.x
Autor:
Angelica, Quartino, Gunilla, Huledal, Erik, Sparve, Maria, Lüttgen, Tjerk, Bueters, Pär, Karlsson, Tina, Olsson, Jonathan, Paraskos, Justine, Maltby, Kristina, Claeson-Bohnstedt, Chi-Ming, Lee, Robert, Alexander, Johanna, Fälting, Björn, Paulsson
Publikováno v:
Clinical pharmacology in drug development. 3(5)
Modulating deposition of Aβ-containing plaques in the brain may be beneficial in treating Alzheimer's disease. β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors have been shown to reduce Aβ in plasma and CSF in healthy voluntee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::519e410b8b8b8e6db411ff9a3f03fcf2
https://pubmed.ncbi.nlm.nih.gov/27129013
https://pubmed.ncbi.nlm.nih.gov/27129013
Autor:
Heather Oakes, Justine Maltby, Robert I. Craggs, Alison Ward, Rick Davies, Malcolm Anderson, Debbie V. Pattison, Philip Mallinder, Donna K. Finch, Caroline Grahames
Publikováno v:
Protein expression and purification. 68(1)
The physiological activities of Interleukin-15 (IL-15) suggest that it could be useful as an immunomodulator to activate the innate immune system, however, the expression and purification yields of recombinant mature IL-15 have typically been low. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8de1e00c8e54a572343cca5521f06f5
https://pubmed.ncbi.nlm.nih.gov/19435602
https://pubmed.ncbi.nlm.nih.gov/19435602
Autor:
Gvido Cebers, S. Budd, Muir Russell, Jonathan Paraskos, David Han, D. Burdette, Robert Alexander, Karen Elsby, Justine Maltby, Tina Olsson, Larry Ereshefsky, Alan R. Kugler, Ronald Goldwater, Naidong Ye
Publikováno v:
Neurobiology of Aging. 35:S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::091703a08b6503452b6d255cbdf5a6bd
https://doi.org/10.1016/j.neurobiolaging.2014.01.033
https://doi.org/10.1016/j.neurobiolaging.2014.01.033