Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Justina Z. Strelitz"'
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2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 2. C-Alkylation of pyrimidines with Mannich bases and application to the synthesis of trimethoprim and analogues
Autor: Barbara Roth, Justina Z. Strelitz, Barbara S. Rauckman
Publikováno v: Journal of medicinal chemistry. 23(4)
A new route to 5-(p-hydroxybenzyl)pyrimidines has been developed which utilizes phenolic Mannich bases plus pyrimidines containing at least two activating groups. The products can be alkylated on the phenolic oxygen or on the pyrimidine N-1 atom, dep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97e850f85f9a8d564f1c5a506df2038
https://pubmed.ncbi.nlm.nih.gov/6991692
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8
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim
Autor: Robert Ferone, Justina Z. Strelitz, Barbara Roth, Edward Aig, S. R. M. Bushby, Carl W. Sigel, Arthur P. Phillips, Barbara S. Rauckman
Publikováno v: Journal of medicinal chemistry. 24(8)
Forty trimethoprim analogues in which the para substituent in the benzene ring was varied were prepared for antibacterial evaluation. All were very potent inhibitors of Escherichia coli dihydrofolate reductase. The similarity of their inhibitory acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666722b9d0fc388d2de0b00130bd857
https://pubmed.ncbi.nlm.nih.gov/7035668
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