Výsledky vyhledávání - "Justina E. Ochoa"

The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

Autor: Enrique J. Sánchez Pozzi, Justina E. Ochoa, Cecilia Lorena Basiglio, Leonardo Martín Pérez, Marcelo G. Roma, Flavia Daniela Toledo

Publikováno v: Archives of Toxicology. 88:1695-1709

Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca2+ increase plays a pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc4c59996bb846a1d12c5dbe251f4a1
https://doi.org/10.1007/s00204-014-1219-5

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Mechanisms involved in spironolactone-induced choleresis in the rat

Autor: Viviana A. Catania, Enrique J. Sánchez-Pozzi, Silvina Stella Maris Villanueva, Marcelo G. Luquita, Aldo D. Mottino, Fernando A. Crocenzi, Justina E. Ochoa, María L. Ruiz, José M. Pellegrino, Mary Vore

Publikováno v: Biochemical Pharmacology. 69:531-539

The mechanisms involved in spironolactone (SL, 200 micromol/kg body weight, 3 days i.p.)-induced choleresis were explored in vivo by evaluating bile salt export pump (Bsep)-, multidrug resistance-associated protein 2 (Mrp2)-, and anion exchanger 2 (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68b8a7bf6c2f51f3f35d447b84a0af6f
https://doi.org/10.1016/j.bcp.2004.10.017

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Physiological concentrations of unconjugated bilirubin prevent oxidative stress-induced hepatocanalicular dysfunction and cholestasis

Autor: Sandra Mónica María Arriaga, Marcelo G. Roma, Enrique J. Sánchez Pozzi, Flavia Daniela Toledo, Aldo D. Mottino, Andrea Carolina Boaglio, Justina E. Ochoa, Cecilia Lorena Basiglio

Publikováno v: RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR

Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most hepatopathies, induces chol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fc94dc61ccd1f6edec82539c9ff50d

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Protein kinase A signals apoptotic activation in glucose-deprived hepatocytes: participation of reactive oxygen species

Autor: Maria C. Larocca, Cristián Favre, Anabela Ferretti, Stella Maris Mattaloni, Justina E. Ochoa

Publikováno v: Apoptosis : an international journal on programmed cell death. 17(5)

Glucose deprivation entails oxidative stress and apoptosis in diverse cell types. Liver tissue shows high tolerance to nutritional stress, however regulation of survival in normal hepatocytes subjected to glucose restriction is unclear. We assessed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59c241565d1e15243bb1377a7f59e4b
https://pubmed.ncbi.nlm.nih.gov/22270152

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Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C

Autor: Enrique J. Sánchez Pozzi, Mary Vore, Justina E. Ochoa, José M. Pellegrino, Marcelo G. Roma, Aldo D. Mottino, Fernando A. Crocenzi, A.E. Zucchetti, Andrea Carolina Boaglio

Publikováno v: Hepatology (Baltimore, Md.). 52(4)

Estradiol 17β-D-glucuronide (E217G) is an endogenous, cholestatic metabolite that induces endocytic internalization of the canalicular transporters relevant to bile secretion: bile salt export pump (Bsep) and multidrug resistance–associated protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb93bbcc517fe4e9c08f02cb8afb420
https://pubmed.ncbi.nlm.nih.gov/20815017

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Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA

Autor: Marcelo G. Roma, Enrique J. Sánchez Pozzi, Justina E. Ochoa, Jalal Ahmed-Choudhury, Leonardo Martín Pérez, Roger Coleman, Elwyn Elias, Piotr Milkiewicz

Publikováno v: Free radical biologymedicine. 40(11)

Oxidative stress elevates Ca2+ and, presumably, activates Ca2+ -dependent PKCs. We analyzed the participation of Ca2+ -dependent PKCs in actin disorganization and tight-junctional impairment induced by the pro-oxidant tert-butylhydroperoxide (tBOOH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83526e82856a30ae22faabcb3d1fdc3
https://pubmed.ncbi.nlm.nih.gov/16716901

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Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes

Autor: Mariana Borgognone, Leonardo Martín Pérez, Cecilia Lorena Basiglio, Justina E. Ochoa, Marcelo G. Roma

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 83(1)

Hydrophobic bile salts induce either necrosis or apoptosis depending on the severity of the injury caused by them. Since bile salt-induced apoptosis is influenced by Ca2+- and protein kinase-signaling pathways, and both necrosis and apoptosis share c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fef0b7492c6568fd9da34feea3f8b0
https://pubmed.ncbi.nlm.nih.gov/15496497

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Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2

Autor: María L, Ruiz, Silvina S M, Villanueva, Marcelo G, Luquita, Enrique J, Sánchez-Pozzi, Fernando A, Crocenzi, José M, Pellegrino, Justina E, Ochoa, Mary, Vore, Aldo D, Mottino, Viviana A, Catania

Publikováno v: Biochemical pharmacology. 69(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb9c3e59b8dfa6df6fd764f8904b63ae
https://pubmed.ncbi.nlm.nih.gov/15652244

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