Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Justin W. Jackson"'
Autor:
Ashish Kalra, Brian T. Welsh, Justin W. Jackson, Janice A. Lansita, Deborah Meshulam, Ajai Pal, Shaun M. Cote
Publikováno v:
International Journal of Toxicology
Myostatin is a negative regulator of skeletal muscle and has become a therapeutic target for muscle atrophying disorders. Although previous inhibitors of myostatin offered promising preclinical data, these therapies demonstrated a lack of specificity
Autor:
Frederick C. Streich, Susan C Lin, Samantha B. Nicholls, Ryan Faucette, Justin W. Jackson, Chris J Boston, Capili Allan, Anastasia Nikiforov, Kevin B. Dagbay, Erin Treece, Gregory J. Carven
Publikováno v:
The Journal of Biological Chemistry
Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015
Autor:
Shaun M. Cote, Gregory J. Carven, Justin W. Jackson, Stefan Wawersik, Michelle Pirruccello-Straub
Publikováno v:
Slas Discovery
Myostatin, a member of the transforming growth factor β (TGFβ) superfamily, is a key regulator of skeletal muscle mass and a therapeutic target for muscle wasting diseases. We developed a human monoclonal antibody, SRK-015, that selectively binds t
Autor:
Nicole Danek, Ashish Kalra, Stefan Wawersik, Ryan R. Faucette, Gregory J. Carven, Constance Martin, Alan Buckler, Anastasia Nikiforov, Frederick C. Streich, Christopher Brueckner, Pichai Raman, Lin Susan, Kevin B. Dagbay, Christopher Littlefield, Justin W. Jackson, Christopher Chapron, Francis T. Danehy, Thomas Schurpf, Christopher Boston, Allison Simpson, Abhishek Datta, Capili Allan
Publikováno v:
Science Translational Medicine. 12
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to primary or acquired resistance. Human tumor profiling and preclinical studies in tumor models hav
Autor:
A. Donovan, Capili Allan, K. J. Turner, Michelle Pirruccello-Straub, K. Long, W. McConaughy, N. K. Mahanthappa, Stefan Wawersik, Gregory J. Carven, L. Salta, C. Boston, M. T. Webster, Justin W. Jackson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic
Autor:
Roxana E. Iacob, Timothy A. Springer, William K. Mcconaughy, Michelle Pirruccello-Straub, Yang Su, Viet Q. Le, Bo Zhao, Yuan Tian, Justin W. Jackson, John R. Engen
Publikováno v:
The EMBO journal. 37(3)
Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understan
Autor:
Viet Q. Le, Yang Su, Justin W. Jackson, Bo Zhao, William K. Mcconaughy, Yuan Tian, Michelle Pirruccello-Straub, Timothy A. Springer, John R. Engen, Roxana E. Iacob
Growth differentiation factor 8 (GDF8)/Myostatin is a latent TGFβ family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloidcleaved GDF8 procomplexes to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658d6eeb557c098b0840d77cb37b2d64
Autor:
Christopher Littlefield, Ashish Kalra, Anastasia Nikiforov, Christopher Boston, Allison Simpson, Constance Martin, Stefan Wawersik, Abhishek Datta, Christopher Chapron, Francis T. Danehy, Thomas Schurpf, Gregory J. Carven, Lin Susan, Justin W. Jackson, Alan Buckler
Publikováno v:
Cancer Research. 79:4090-4090
Despite the clinical breakthroughs achieved by checkpoint blockade therapy (CBT), a majority of patients treated with PD-(L)1 inhibitors fail to respond due to primary or acquired resistance. TGFβ signaling has recently been implicated as a mechanis
Autor:
Soumya S. Ray, Stephanie Kang, Scott A. Gerber, Min Liu, Alexandra D. Zaitsev, Gregory D. Cuny, Marcie A. Glicksman, Justin W. Jackson
Publikováno v:
Biochemistry. 50:9399-9408
Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson's disease (PD). Here, we characterize the kinetic and catalytic mechanisms