Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Justin V Joseph"'
Autor:
Huiqiang Cai, Bin Zhang, Johanne Ahrenfeldt, Justin V. Joseph, Maria Riedel, Zongliang Gao, Sofie K. Thomsen, Ditte S. Christensen, Rasmus O. Bak, Henrik Hager, Mikkel H. Vendelbo, Xin Gao, Nicolai Birkbak, Martin K. Thomsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Metastatic prostate cancer (PCa) poses a significant therapeutic challenge with high mortality rates. Utilizing CRISPR-Cas9 in vivo, we target five potential tumor suppressor genes (Pten, Trp53, Rb1, Stk11, and RnaseL) in the mouse prostate,
Externí odkaz:
https://doaj.org/article/b26426d9b48c4a0dba41510dd87eb43f
Autor:
Justin V Joseph, Ingrid A M van Roosmalen, Ellen Busschers, Tushar Tomar, Siobhan Conroy, Ellie Eggens-Meijer, Natalia Peñaranda Fajardo, Milind M Pore, Veerakumar Balasubramanyian, Michiel Wagemakers, Sjef Copray, Wilfred F A den Dunnen, Frank A E Kruyt
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145393 (2015)
Glioblastoma (GBM) is a highly infiltrative brain tumor in which cells with properties of stem cells, called glioblastoma stem cells (GSCs), have been identified. In general, the dominant view is that GSCs are responsible for the initiation, progress
Externí odkaz:
https://doaj.org/article/21fcd2628e2b4d62b7ed4ed1c898e049
Autor:
Siobhan Conroy, Frank A E Kruyt, Justin V Joseph, Veerakumar Balasubramaniyan, Krishna P Bhat, Michiel Wagemakers, Roelien H Enting, Annemiek M E Walenkamp, Wilfred F A den Dunnen
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115687 (2014)
Molecular signatures in Glioblastoma (GBM) have been described that correlate with clinical outcome and response to therapy. The Proneural (PN) and Mesenchymal (MES) signatures have been identified most consistently, but others including Classical (C
Externí odkaz:
https://doaj.org/article/026749e0cbcc49509bcba8d7ea8576c6
Autor:
Soran Dakhel, Silvia Remeseiro, Lena Gunhaga, Wayne I. L. Davies, Justin V. Joseph, Tushar Tomar
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-17 (2021)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background Organ culture models have been used over the past few decades to study development and disease. The in vitro three-dimensional (3D) culture system of organoids is well known, however, these 3D systems are both costly and difficult to cultu
Autor:
Tushar Tomar, Barbara Klink, Rolf Bjerkvig, Lars A. Rømo Ystaas, Zhang Di, Frida Haukas, Heiko Wurdak, Justine Rudewicz, Frode S. Berven, Amalie Trones, Lalit Rane, Justin V. Joseph, Even Birkeland, Sylvain Cuvellier, Frank Winkler, Frank A.E. Kruyt, Peter O'Toole, Jubayer A Hossain, Jian Wang, Matteo Gambaretti, Joanne Marrison, Thomas Mathivet, Andreas Bikfalvi, Wenjing Zhou, Hrvoje Miletic, Thomas Daubon, Bronwyn K. Irving, Sandra Ninzima, Simon Storevik, Luiz H. Geraldo, Capucine R. Magaut, Abdul Latif, Joris Guyon
Publikováno v:
Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2021, ⟨10.1093/neuonc/noab212⟩
Joseph, J V, Magaut, C R, Storevik, S, Geraldo, L H, Mathivet, T, Latif, M A, Rudewicz, J, Guyon, J, Gambaretti, M, Haukas, F, Trones, A, Rømo Ystaas, L A, Hossain, J A, Ninzima, S, Cuvellier, S, Zhou, W, Tomar, T, Klink, B, Rane, L, Irving, B K, Marrison, J, O'Toole, P, Wurdak, H, Wang, J, Di, Z, Birkeland, E, Berven, F S, Winkler, F, Kruyt, F A E, Bikfalvi, A, Bjerkvig, R, Daubon, T & Miletic, H 2022, ' TGF-β promotes microtube formation in glioblastoma through thrombospondin 1 ', Neuro-Oncology, vol. 24, no. 4, pp. 541-553 . https://doi.org/10.1093/neuonc/noab212
Neuro-Oncology, 24(4). Oxford University Press
Neuro-Oncology, Oxford University Press (OUP), 2021, ⟨10.1093/neuonc/noab212⟩
Joseph, J V, Magaut, C R, Storevik, S, Geraldo, L H, Mathivet, T, Latif, M A, Rudewicz, J, Guyon, J, Gambaretti, M, Haukas, F, Trones, A, Rømo Ystaas, L A, Hossain, J A, Ninzima, S, Cuvellier, S, Zhou, W, Tomar, T, Klink, B, Rane, L, Irving, B K, Marrison, J, O'Toole, P, Wurdak, H, Wang, J, Di, Z, Birkeland, E, Berven, F S, Winkler, F, Kruyt, F A E, Bikfalvi, A, Bjerkvig, R, Daubon, T & Miletic, H 2022, ' TGF-β promotes microtube formation in glioblastoma through thrombospondin 1 ', Neuro-Oncology, vol. 24, no. 4, pp. 541-553 . https://doi.org/10.1093/neuonc/noab212
Neuro-Oncology, 24(4). Oxford University Press
Background Microtubes (MTs), cytoplasmic extensions of glioma cells, are important cell communication structures promoting invasion and treatment resistance through network formation. MTs are abundant in chemoresistant gliomas, in particular, gliobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4668e5475d8914bb38b01f4e352afc0e
https://hal.archives-ouvertes.fr/hal-03442147
https://hal.archives-ouvertes.fr/hal-03442147
Publikováno v:
Current Opinion in Pharmacology, 61, 91-97. ELSEVIER SCI LTD
Current Opinion in Pharmacology
Current Opinion in Pharmacology, Elsevier, 2021, 61, pp.91-97. ⟨10.1016/j.coph.2021.08.019⟩
Vareecal Joseph, J, Blaavand, M S, Daubon, T, Kruyt, F AE & Thomsen, M K 2021, ' Three-dimensional culture models to study glioblastoma — current trends and future perspectives ', Current Opinion in Pharmacology, vol. 61, pp. 91-97 . https://doi.org/10.1016/j.coph.2021.08.019
Joseph, J V, Blaavand, M S, Daubon, T, Kruyt, F AE & Thomsen, M K 2021, ' Three-dimensional culture models to study glioblastoma — current trends and future perspectives ', Current Opinion in Pharmacology, vol. 61, pp. 91-97 . https://doi.org/10.1016/j.coph.2021.08.019
Current Opinion in Pharmacology
Current Opinion in Pharmacology, Elsevier, 2021, 61, pp.91-97. ⟨10.1016/j.coph.2021.08.019⟩
Vareecal Joseph, J, Blaavand, M S, Daubon, T, Kruyt, F AE & Thomsen, M K 2021, ' Three-dimensional culture models to study glioblastoma — current trends and future perspectives ', Current Opinion in Pharmacology, vol. 61, pp. 91-97 . https://doi.org/10.1016/j.coph.2021.08.019
Joseph, J V, Blaavand, M S, Daubon, T, Kruyt, F AE & Thomsen, M K 2021, ' Three-dimensional culture models to study glioblastoma — current trends and future perspectives ', Current Opinion in Pharmacology, vol. 61, pp. 91-97 . https://doi.org/10.1016/j.coph.2021.08.019
Glioblastoma (GBM) is the most prevalent form of primary malignant brain tumor in adults and remains almost invariably lethal owing to its aggressive and invasive nature. There have only been marginal improvements in its bleak survival rate of 12-15
Autor:
Kristoffer Riecken, Sandra Ninzima, Abdul Latif, Jiwan Ghimire, Francisco Azuaje, Krishna M. Talasila, Lars A. Rømo Ystaas, Jubayer A Hossain, Rolf Bjerkvig, Arnaud Muller, Justin V. Joseph, Boris Fehse, Hrvoje Miletic
Publikováno v:
Neuro-Oncology
Neuro Oncol
Neuro Oncol
Background Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when replication-defective vectors
Autor:
Justin V. Joseph, Huiqiang Cai, Brian Hansen, Soren R. Paludan, Mikkel Vendelbo, Martin K. Thomsen
Publikováno v:
Cancer Research. 82:3512-3512
Intrinsic malignant brain tumors, such as glioblastoma (GBM) are frequently resistant to immunotherapy with few hyper-mutated glioblastomas showing response. Here we have applied a long-term treatment with STING agonist and PD-1 inhibitors alone and
Autor:
Jian Wang, Frank A.E. Kruyt, Joanne Marrison, Capucine R. Magaut, Thomas Mathivet, Bronwyn K. Irving, Zhang Di, Frida Haukas, Rolf Bjerkvig, Heiko Wurdak, Justin V. Joseph, Barbara Klink, Lalit Rane, Wenjing Zhou, Sandra Ninzima, Hrvoje Miletic, Joris Guyon, Frank Winkler, Simon Storevik, Luiz H. Geraldo, Justine Rudewicz, Tushar Tomar, Lars A. Rømo Ystaas, Abdul Latif, Thomas Daubon, Amalie Trones, Matteo Gambaretti, Andreas Bikfalvi, Peter O'Toole, Jubayer A Hossain
Microtubes (MTs), cytoplasmic extensions of glioma cells, are important cell communication structures promoting invasion and treatment resistance through network formation. MTs are abundant in chemoresistant gliomas, in particular glioblastomas (GBMs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bc8703dd8788037fdf94f13a875b918
https://doi.org/10.1101/2021.02.22.431443
https://doi.org/10.1101/2021.02.22.431443
Autor:
Maria Riedel, Mikkel H. Vendelbo, Martin F. Berthelsen, Siv L. Leknes, Mette Abildgaard Pedersen, Henrik Hager, Martin K. Thomsen, Justin V Joseph
Publikováno v:
Berthelsen, M F, Leknes, S L, Riedel, M, Pedersen, M A, Joseph, J V, Hager, H, Vendelbo, M H & Thomsen, M K 2021, ' Comparative analysis of Stk11/Lkb1 versus Pten deficiency in lung adenocarcinoma induced by CRISPR/Cas9 ', Cancers, vol. 13, no. 5, 974 . https://doi.org/10.3390/cancers13050974
Cancers
Berthelsen, M F, Leknes, S L, Riedel, M, Pedersen, M A, Joseph, J V, Hager, H, Vendelbo, M H & Thomsen, M K 2021, ' Comparative analysis of stk11/lkb1 versus pten deficiency in lung adenocarcinoma induced by crispr/cas9 ', Cancers, vol. 13, no. 5, 974 . https://doi.org/10.3390/cancers13050974
Volume 13
Issue 5
Cancers, Vol 13, Iss 974, p 974 (2021)
Cancers
Berthelsen, M F, Leknes, S L, Riedel, M, Pedersen, M A, Joseph, J V, Hager, H, Vendelbo, M H & Thomsen, M K 2021, ' Comparative analysis of stk11/lkb1 versus pten deficiency in lung adenocarcinoma induced by crispr/cas9 ', Cancers, vol. 13, no. 5, 974 . https://doi.org/10.3390/cancers13050974
Volume 13
Issue 5
Cancers, Vol 13, Iss 974, p 974 (2021)
Simple Summary Lung cancer is by far the leading cause of cancer induced mortality worldwide with a median five-year survival rate of 19 percent. Genome sequencing of lung cancer samples has revealed several key mutated genes, which could be implicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdee9b431fc94878ab9355a9de3b557c
https://pure.au.dk/portal/da/publications/comparative-analysis-of-stk11lkb1-versus-pten-deficiency-in-lung-adenocarcinoma-induced-by-crisprcas9(879a46bc-347a-493b-b388-c64a846f769c).html
https://pure.au.dk/portal/da/publications/comparative-analysis-of-stk11lkb1-versus-pten-deficiency-in-lung-adenocarcinoma-induced-by-crisprcas9(879a46bc-347a-493b-b388-c64a846f769c).html