Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Justin T. Whitfield"'
Autor:
Ross L. Levine, Zhu A. Cao, Gary Vanasse, Justin T. Whitfield, Keith Cordner, Shira Esther Eisman, Tyler Longmire, Xianhui Rong, Sean Devlin, Andriy Derkach, Wenbin An, Bing Li, Aishwarya Krishnan, Shoron Mowla, Barbara Spitzer, Richard Koche, Benjamin Durham, Amritha Varshini Hanasoge Somasundara, Maria Pinzon-Ortiz, Raajit K. Rampal
Complete Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e6f508df08f9ccbcd0ae8b58abafd7
https://doi.org/10.1158/1078-0432.22479654
https://doi.org/10.1158/1078-0432.22479654
Autor:
Cesar H. Benjumea, James B. Machamer, Elliot J. Glotfelty, Charles B. Shoemaker, Patrick M. McNutt, Christopher A. Angeles, Luis Tenezaca, Kyle E.M. Kelly, Justin T. Whitfield, Jaclyn Cika, Celinia A. Ondeck, Edwin J. Vazquez-Cintron, Konstantin Ichtchenko, Mark Mangkhalakhili, Philip A. Band
Publikováno v:
Sci Transl Med
Botulism is caused by a potent neurotoxin that blocks neuromuscular transmission, resulting in death by asphyxiation. Currently, the therapeutic options are limited and there is no antidote. Here, we harness the structural and trafficking properties
Autor:
Shira E. Eisman, Ross L. Levine, Wenbin An, Bing Li, Benjamin H. Durham, Maria Pinzon-Ortiz, Barbara Spitzer, Aishwarya Krishnan, Shoron Mowla, Andriy Derkach, Gary J. Vanasse, Xianhui Rong, Raajit K. Rampal, Sean M. Devlin, Justin T. Whitfield, Keith B. Cordner, Tyler Longmire, Amritha Varshini Hanasoge Somasundara, Zhu A Cao, Richard Koche
Publikováno v:
Clin Cancer Res
Purpose: The JAK1/2 inhibitor ruxolitinib has demonstrated significant benefits for patients with myeloproliferative neoplasms (MPN). However, patients often lose response to ruxolitinib or suffer disease progression despite therapy with ruxolitinib.
Autor:
Ross L. Levine, Jacob L. Glass, Elodie Pronier, Justin T. Whitfield, Benjamin H. Durham, Robert L. Bowman, Richard Koche, Cyriac Kandoth, Barry S. Taylor, Jihae Ahn, Amritha Varshini Hanasoge Somasundara, Antoine Gruet, Raajit K. Rampal, Ari Melnick, Tiffany R. Merlinsky
Publikováno v:
Blood. 132:1265-1278
Genetic studies have identified recurrent somatic mutations in acute myeloid leukemia (AML) patients, including in the Wilms’ tumor 1 (WT1) gene. The molecular mechanisms by which WT1 mutations contribute to leukemogenesis have not yet been fully e
Autor:
Ari Melnick, Sara C. Meyer, Rebecca Maher, Elodie Pronier, Martin S. Tallman, Alan H. Shih, Francine E. Garrett-Bakelman, Hiroyoshi Kunimoto, Franck Rapaport, Abbas Nazir, Justin T. Whitfield, Kaitlyn Shank, Cem Meydan, Ross L. Levine
Summary Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies, including TET2 and NRAS mutations. Concurrent Tet2 loss and Nras G12D expression in hematopoietic cells induced myeloid transformation, with a ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c49c5b431a9fd21865f7b0f0dcce960
https://europepmc.org/articles/PMC5760367/
https://europepmc.org/articles/PMC5760367/
Autor:
Justin T. Whitfield, Gerald A. Meininger, Michael E. Nance, Steven S. Segal, Yi Zhu, Kenneth S. Campbell, Laurin M. Hanft, Anne K. Gibson, Timothy L. Domeier, Kerry S. McDonald
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 309:H918-H925
The Frank-Starling mechanism, whereby increased diastolic filling leads to increased cardiac output, depends on increasing the sarcomere length ( Ls) of cardiomyocytes. Ventricular stiffness increases with advancing age, yet it remains unclear how su
Publikováno v:
Biophysical Journal. 110(3)
Cardiac excitation-contraction coupling (ECC) occurs via calcium-induced calcium release and is therefore critically dependent on precise regulation of intracellular calcium homeostasis. Cardiomyocytes of the aged heart exhibit alterations in calcium