Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Justin T. Tometich"'
Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A
Autor:
Chelseá B. Johnson-Hence, Kathyayini P. Gopalakrishna, Darren Bodkin, Kara E. Coffey, Ansen H.P. Burr, Syed Rahman, Ali T. Rai, Darryl A. Abbott, Yelissa A. Sosa, Justin T. Tometich, Jishnu Das, Timothy W. Hand
Publikováno v:
bioRxiv
Immunoglobulin A (IgA) is secreted into breast milk and is critical to both protecting against enteric pathogens and shaping the infant intestinal microbiota. The efficacy of breast milk-derived maternal IgA (BrmIgA) is dependent upon its specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b903f5d94bc716e63287b07717ab8
https://doi.org/10.1101/2023.03.16.532940
https://doi.org/10.1101/2023.03.16.532940
Autor:
Merlin Airik, Blake McCourt, Tugba Tastemel Ozturk, Amy B. Huynh, Xiaoyi Zhang, Justin T. Tometich, Rezan Topaloglu, Hasan Ozen, Diclehan Orhan, Kari Nejak‐Bowen, Satdarshan P. Monga, Timothy W. Hand, Fatih Ozaltin, Rannar Airik
Publikováno v:
FASEB J
Congenital hepatic fibrosis (CHF) is a developmental liver disease that is caused by mutations in genes that encode for ciliary proteins and is characterized by bile duct dysplasia and portal fibrosis. Recent work has demonstrated that mutations in A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e15605eb26b039b08bc3af670ff1f8
https://doi.org/10.1096/fj.202101387r
https://doi.org/10.1096/fj.202101387r
Autor:
Michael J. Morowitz, Junyi Ji, Timothy W. Hand, Kathyayini P. Gopalakrishna, Justin T. Tometich, Benjamin R Macadangdang, Ansen H.P. Burr, Robyn Baker, Misty Good, Brian Firek, Congrong Ma, Matthew B. Rogers
Publikováno v:
Nature medicine
Neonates are protected from colonizing bacteria by antibodies secreted into maternal milk. Necrotizing enterocolitis (NEC) is a disease of neonatal preterm infants with high morbidity and mortality that is associated with intestinal inflammation driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce6de75e59e97323113e60077f8ef00
http://europepmc.org/articles/PMC7424541
http://europepmc.org/articles/PMC7424541
Autor:
Timothy W. Hand, Tullia C. Bruno, Ansen H.P. Burr, Abigail E. Overacre-Delgoffe, Anthony R. Cillo, Hannah Bumgarner, Amrita Bhattacharjee, Justin T. Tometich, Dario A. A. Vignali
SummaryColorectal cancer (CRC) is a common and deadly disease, and patients with metastatic tumors often fail to respond to therapy. While select members of the microbiome are associated with improved anti-tumor immunity, mechanistic understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86c947a68d46d6dfd38885366f2036d
https://doi.org/10.1101/2021.01.27.428417
https://doi.org/10.1101/2021.01.27.428417
Autor:
Amrita Bhattacharjee, Tullia C. Bruno, Justin T. Tometich, Abigail E. Overacre-Delgoffe, Timothy W. Hand, Anthony R. Cillo, Hannah Bumgarner, Dario A. A. Vignali, Ansen H.P. Burr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Colorectal cancer remains one of the most common and deadliest cancers worldwide and effective therapies are lacking. While immunotherapy has revolutionized treatment for many cancers, the overwhelming majority of colorectal cancer patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671beba323e8353879562552fcae4936
https://doaj.org/article/5d8a688391474a7895d9820c241efc0f
https://doaj.org/article/5d8a688391474a7895d9820c241efc0f
Autor:
Elizabeth B. Norton, Amrita Bhattacharjee, Denise Morais da Fonseca, Yasmine Belkaid, Sean P. Spencer, Oliver J. Harrison, Abigail E. Overacre-Delgoffe, Justin T. Tometich, Ansen H.P. Burr, Timothy W. Hand, Jason A. Hall, Deyi Yang, Brydie R. Huckestein, Jonathan L. Linehan
SummaryEnvironmental Enteric Dysfunction (EED) is an intestinal disease caused by malnutrition and infection that leads to malabsorption and stunting. EED is also associated with a reduced efficacy of oral vaccines. We show in a microbiota and diet-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178b4956afd467f519303ac1c36fb567
https://doi.org/10.1101/2020.06.03.130831
https://doi.org/10.1101/2020.06.03.130831
Autor:
Brydie R. Huckestein, Oliver J. Harrison, Deyi Yang, Ansen H.P. Burr, Justin T. Tometich, Jason A. Hall, Sean P. Spencer, Elizabeth B. Norton, Jonathan L. Linehan, Yasmine Belkaid, Amrita Bhattacharjee, Denise Morais da Fonseca, Abigail E. Overacre-Delgoffe, Timothy W. Hand
Publikováno v:
Immunity
Summary Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection. EED is associated with stunting in children and reduced efficacy of oral vaccines. To study the mechanisms of ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4904a8b23ac488a38a9d445a0de9444b
https://pubmed.ncbi.nlm.nih.gov/34348118
https://pubmed.ncbi.nlm.nih.gov/34348118
Autor:
Sridhar T. Narla, Mehdi Nouraie, Daniel Bushnell, Timothy W. Hand, Justin T. Tometich, Carlton M. Bates, Caitlin Schaefer
Publikováno v:
Am J Pathol
Cyclophosphamide may cause hemorrhagic cystitis and eventually bladder urothelial cancer. Genetic determinants for poor outcomes are unknown. We assessed actions of fibroblast growth factor receptor (FGFR) 2 in urothelium after cyclophosphamide expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fc602ab6117d01aeb7bde50f170dc8
https://pubmed.ncbi.nlm.nih.gov/33385344
https://pubmed.ncbi.nlm.nih.gov/33385344
Autor:
Abigail E. Overacre-Delgoffe, Hannah J. Bumgarner, Anthony R. Cillo, Ansen H. P. Burr, Justin T. Tometich, Amrita Bhattacharjee, Tullia C. Bruno, Dario A. A. Vignali, Timothy W. Hand
Publikováno v:
Cancer Immunology Research. 10:PR08-PR08
Colorectal cancer (CRC) is the third most common and one of the deadliest cancers in the US, and the survival rate for advanced cases is poor. Immunotherapy, especially checkpoint blockade, has revolutionized the way cancer is treated and has resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18b284b2e547e074a25d4ee45edcc0e
https://doi.org/10.1158/2326-6074.tumimm21-pr08
https://doi.org/10.1158/2326-6074.tumimm21-pr08
Autor:
Amrita Bhattacharjee, Abigail E. Overacre-Delgoffe, Justin T. Tometich, Timothy W. Hand, Anthony R. Cillo, Dario A. A. Vignali, Hannah Bumgarner, Tullia C. Bruno, Ansen H.P. Burr
Publikováno v:
Immunity. 54:2812-2824.e4
Summary The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Here, we examined the impact of microbiota-specific T cells in anti-colorectal cancer (CRC) immunity. Intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f65c777d07fb322f79d3a685720720
https://doi.org/10.1016/j.immuni.2021.11.003
https://doi.org/10.1016/j.immuni.2021.11.003