Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Justin T. Malinowski"'
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc1527608c162798f4bf1d0f00eae6e
https://doi.org/10.1002/0471266949.bmc262
https://doi.org/10.1002/0471266949.bmc262
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(9)
Poor prognosis coupled with significant economic burden makes heart failure (HF) one of the largest issues currently facing the world population. Although a significant number of new therapies have emerged over the past 20 years to treat the underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f2c0ff868d5bfc6cee64a7e579d18b
https://pubmed.ncbi.nlm.nih.gov/29615340
https://pubmed.ncbi.nlm.nih.gov/29615340
Autor:
Federico Sorana, Robert J. Sharpe, Justin T. Malinowski, J. Christopher Luft, Charles J. Bowerman, Jeffrey S. Johnson, Joseph M. DeSimone
The synthesis and biological analysis of a number of novel congeners of the aminocyclopentitol pactamycin is described. Specific attention was paid to the preparation of derivatives at crucial synthetic branch points of the parent structure, and biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adad073b5e889aca763432673c5d9ba1
Publikováno v:
ChemInform. 45
An asymmetric total synthesis of the aminocyclopentitol pactamycin is described. The title compound is delivered in 15 steps from 2,4-pentanedione. Critical to this approach was the exploitation of a complex symmetry-breaking reduction strategy to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4603027f00467737296efc8db5728943
https://doi.org/10.1002/chin.201422202
https://doi.org/10.1002/chin.201422202
Publikováno v:
ChemInform. 44
Key steps of the described synthesis are an enantioselective Mannich reaction affording (III), and a symmetry-breaking reduction sequence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::651837c94c8f779c56e601decc455275
https://doi.org/10.1002/chin.201338207
https://doi.org/10.1002/chin.201338207
An asymmetric total synthesis of the aminocyclopentitol pactamycin is described, which delivers the title compound in 15 steps from 2,4-pentanedione. Critical to this approach was the exploitation of a complex symmetry-breaking reduction strategy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855e0688e955be967b1763b51e966e46
Publikováno v:
ChemInform. 43
The condensation of nitronates (I) with imidoyl chloride (II) followed by a [3,3]-rearrangement affords desired carbamates (III).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40190e5e80fb1282ba1698f3f3592e2
https://doi.org/10.1002/chin.201246034
https://doi.org/10.1002/chin.201246034
Autor:
Daniel C. Schmitt, Gregory R. Boyce, Xin Linghi, Jeffrey S. Johnson, Justin T. Malinowski, Stephen N. Greszler, Kimberly M. Steward, Andrew Duncan Satterfield, David A. Nicewicz
Publikováno v:
ChemInform. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0029746fd2f0dffacf76b79ca5e31baa
https://doi.org/10.1002/chin.201229262
https://doi.org/10.1002/chin.201229262
An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea functionality allows for its participation in a diastereoselective, chelation-controlled addition of organometal nucleophiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b984099844d79fbc0bfa3e5676f4a
Publikováno v:
ChemInform. 42
Reformatsky reagents react sequentially with silyl glyoxylates and β-lactones to give highly functionalized Claisen condensation products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae945a6028898209ec638ef38508b49
https://doi.org/10.1002/chin.201118050
https://doi.org/10.1002/chin.201118050