Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Justin T Gibson"'
1
Akademický článek
Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinoma.
Autor: Justin T Gibson, Katlyn E Norris, Gal Wald, Claire M Buchta Rosean, Lewis J Thomas, Shannon K Boi, Laura A Bertrand, Megan Bing, Jennifer B Gordetsky, Jessy Deshane, Peng Li, James A Brown, Kenneth G Nepple, Lyse A Norian
Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0233795 (2020)
Understanding the effects of obesity on the immune profile of renal cell carcinoma (RCC) patients is critical, given the rising use of immunotherapies to treat advanced disease and recent reports of differential cancer immunotherapy outcomes with obe
Externí odkaz: https://doaj.org/article/ad0135c8e8374a1c905d5a81d2e63135
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2
Akademický článek
Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer
Autor: Justin T. Gibson, Rachael M. Orlandella, William J. Turbitt, Michael Behring, Upender Manne, Robert E. Sorge, Lyse A. Norian
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Nearly 70% of adults in the US are currently overweight or obese. Despite such high prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes remains incompletely understood, particularly in patients with breast cancer. Here,
Externí odkaz: https://doaj.org/article/5decd44041334880821957a320c309d0
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6
Randomized trial of weight loss in primary breast cancer: Impact on body composition, circulating biomarkers and tumor characteristics
Autor: Robert A. Oster, Andrew D. Frugé, Lyse A. Norian, Eddy S. Yang, Helen Krontiras, Wendy Demark-Wahnefried, William E. Grizzle, Justin T. Gibson, Lee W. Jones, Shuko Harada, Maria Azrad, Deborah L. Della Manna, Laura Q. Rogers
Publikováno v: International Journal of Cancer
Obesity adversely impacts overall and cancer‐specific survival among breast cancer patients. Preclinical studies demonstrate negative energy balance inhibits cancer progression; however, feasibility and effects in patients are unknown. A two‐arm,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c30928f7a6840be259e5d1928b3b571
https://doi.org/10.1002/ijc.32637
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8
The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer
Autor: Lyse A. Norian, William J. Turbitt, Rachael M. Orlandella, Peng Li, Daniel L. Smith, Shannon K. Boi, Justin T. Gibson
Publikováno v: Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2872, p 2872 (2020)
Although immune checkpoint inhibitors and targeted therapeutics have changed the landscape of treatment for renal cell carcinoma (RCC), most patients do not experience significant clinical benefits. Emerging preclinical studies report that nutrition-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aeef58270f3b174982e29453784a089
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9
Therapeutic Time-restricted Feeding Reduces Renal Tumor Bioluminescence in Mice but Fails to Improve Anti-CTLA-4 Efficacy
Autor: Rachael M. Orlandella, Lyse A. Norian, William J. Turbitt, Courtney M. Peterson, Justin T. Gibson
Publikováno v: Anticancer Res
Background/aim Dietary interventions like time-restricted feeding (TRF) show promising anti-cancer properties. We examined whether therapeutic TRF alone or combined with immunotherapy would diminish renal tumor growth in mice of varying body weights.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bad1a0b6f61d6454070070b0f97161e
https://pubmed.ncbi.nlm.nih.gov/32988866
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