Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Justin T Cruite"'
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003044 (2012)
We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse. We used a transgenic model, in situ tetramer staining to distinguish antigen specific CD8 T cel
Externí odkaz:
https://doaj.org/article/591af495eaa64c15bf35ff826e8fc10e
Autor:
Justin T. Cruite, Geoffrey P. Dann, Jianwei Che, Katherine A. Donovan, Silas Ferrao, Scott B. Ficarro, Eric S. Fischer, Nathanael S. Gray, Fidel Huerta, Nikki R. Kong, Hu Liu, Jarrod A. Marto, Rebecca J. Metivier, Radosław P. Nowak, Breanna L. Zerfas, Lyn H. Jones
Publikováno v:
RSC chemical biology. 3(9)
Electrophilic biocompatible warheads, particularly cysteine-reactive acrylamides, have enabled the development of covalent inhibitor drugs and chemical biology probes, but cysteine is rarely present in protein binding sites. Therefore, expansion of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3397cdcdeeeacde95829c4058ddb9df1
https://pubmed.ncbi.nlm.nih.gov/36128501
https://pubmed.ncbi.nlm.nih.gov/36128501
Autor:
Justin T. Cruite, Gabriela Kovacikova, Kenzie A. Clark, Anne K. Woodbrey, Karen Skorupski, F. Jon Kull
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-9 (2019)
The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the diarrheal disease cholera. Unsaturated fatty acids (UFAs) found in bile inhibit the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb91d484d416a3132dc8fb3429d63fc
https://doi.org/10.1038/s42003-019-0686-x
https://doi.org/10.1038/s42003-019-0686-x
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The crystal structure of an inactive variant of the the quorum-sensing master transcription regulator HapR from Vibrio cholerae suggests that its inactivity is owing to steric clashes and charge repulsion with the phosphate backbone of DNA.
HapR
HapR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b12b33ff5b04a4edb8ad4a0896df55f
https://pubmed.ncbi.nlm.nih.gov/29870016
https://pubmed.ncbi.nlm.nih.gov/29870016
Publikováno v:
Virology. 442:114-121
Lassa virus (LASV) is a BSL-4 restricted agent. To allow study of infection by LASV under BSL-2 conditions, we generated a recombinant virus in which the LASV glycoprotein (Gp) was placed on the backbone of lymphocytic choriomeningitis virus (LCMV) C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f109b32417564898b7bd581a58eef1
https://doi.org/10.1016/j.virol.2013.04.010
https://doi.org/10.1016/j.virol.2013.04.010
Autor:
Abegail A. Andaya, Andrew M. Lee, Michael B. A. Oldstone, Matthew J. Trifilo, Johan Paulsson, Justin T. Cruite
Publikováno v:
Virology. 411(1):1-8
Earlier studies indicated that transgenic (tg) mice engineered to express prion protein (PrP) lacking the glycophosphatidylinositol (GPI−/−) membrane anchor formed abnormal proteinase-resistant prion (PrPsc) amyloid deposits in their brains and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085c838e66fc90eb3d0466223ad2679b
Publikováno v:
Biochemistry. 50:1618-1623
Cellular PrP is actively cycled between the cell surface and the endosomal pathway. The exact site and mechanism of conversion from PrP(C) to PrP(Sc) remain unknown. We have previously used recombinant antibodies containing grafts of PrP sequence to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b7b53cac142ba1d80c70cf906d90e1
https://doi.org/10.1021/bi1017683
https://doi.org/10.1021/bi1017683
Autor:
Monica Schaller, Gil C. Abalos, Anne Bellon, Laura Solforosi, Justin T. Cruite, R. Anthony Williamson
Publikováno v:
Journal of Biological Chemistry. 282:7465-7471
Direct interaction between endogenous cellular prion protein (PrP(C)) and misfolded, disease-associated (PrP(Sc)) conformers is a key event in prion propagation, which precedes templated conversion of PrP(C) into nascent PrP(Sc) and prion infectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0654720479523dbe43347b4abdb9c3bf
https://doi.org/10.1074/jbc.m610051200
https://doi.org/10.1074/jbc.m610051200
Publikováno v:
The FASEB Journal. 29
The epidemic diarrheal disease cholera is caused by the ingestion of food or water contaminated with the gram-negative bacterium Vibrio cholerae. Cholera toxin (CT) and the toxin-coregulated pilus ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ab2ab876e8024c04da7eb32510f44b6
https://doi.org/10.1096/fasebj.29.1_supplement.lb204
https://doi.org/10.1096/fasebj.29.1_supplement.lb204
Autor:
Justin T. Cruite, Laura Solforosi, Michael B. A. Oldstone, Anne Ward, Young Pyo Choi, Suzette A. Priola, S. A. McCall, R. A. Williamson, Matthew J. Trifilo
Publikováno v:
Journal of virology. 87(17)
In most forms of prion disease, infectivity is present primarily in the central nervous system or immune system organs such as spleen and lymph node. However, a transgenic mouse model of prion disease has demonstrated that prion infectivity can also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47a4641cb5f4140e7f18192b2c661c2
https://pubmed.ncbi.nlm.nih.gov/23785217
https://pubmed.ncbi.nlm.nih.gov/23785217