Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Justin Simms"'
Autor:
Ian E. Blanchard, Ryan Kozicky, Dana Dalgarno, Justin Simms, Stacy Goulder, Tyler S. Williamson, Susan Biesbroek, Lenore Page, Karen Leaman, Suzanne Snozyk, Lyle Redman, Keith Spackman, Christopher J. Doig, Eddy S. Lang, Gerald Lazarenko
Publikováno v:
BMC Emergency Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Community Paramedics (CPs) require access to timely blood analysis in the field to guide treatment and transport decisions. Point of care testing (POCT), as opposed to laboratory analysis, may offer a solution, but limited researc
Externí odkaz:
https://doaj.org/article/fb2b2639ebeb47dd94cdbebbaf06d9c8
Autor:
Keith Spackman, G. Lazarenko, Ryan Kozicky, Justin Simms, Eddy Lang, Susan Biesbroek, Lyle Redman, Dana Dalgarno, Stacy Goulder, Suzanne Snozyk, Tyler Williamson, Christopher J. Doig, Lenore Page, Karen Leaman, Ian E. Blanchard
Publikováno v:
BMC Emergency Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Emergency Medicine
BMC Emergency Medicine
Background Community Paramedics (CPs) require access to timely blood analysis in the field to guide treatment and transport decisions. Point of care testing (POCT), as opposed to laboratory analysis, may offer a solution, but limited research exists
Autor:
Sagar Lonial, Ranjan Maity, Paola Neri, Nizar J. Bahlis, Justin Simms, Ines Tagoug, Jonathan J Keats, Daniel Auclair
Publikováno v:
Blood. 128:120-120
Background: IMiDs neomorphe the substrates binding of CRL4_DDB1_ROC1 E3 ligase through their interaction with the adaptor protein Cereblon (CRBN) triggering the proteasomal degradation of IKZF1/IKZF3. This binding results from hydrogen bonds forming
Autor:
Fariborz Kolvear, Peter Duggan, Ines Tagoug, Jonathan J Keats, Paola Neri, Nizar J. Bahlis, Jacquelyn Babich, Ranjan Maity, Leif Bergsagel, Justin Simms, Victor H Jimenez-Zepeda
Publikováno v:
Blood. 126:4175-4175
Background: IMiDs are now recognized to promote the proteasomal degradation of IKZF1/3 and the transcriptional repression of MYC and IRF4. MYC locus rearrangement is a recurrent somatic event in MM and results in MYC repositioning near superenhancers
Autor:
Paola Neri, Nizar J. Bahlis, Ranjan Maity, Victor H Jimenez-Zepeda, Ines Tagoug, Peter Duggan, Li Ren, Jiri Slaby, Justin Simms
Publikováno v:
Blood. 124:639-639
Background: IMiDs cytotoxicity in MM cells is mediated through their binding to CRBN within the cullin ring (CRL4) ligase. This binding triggers the ubiquitylation and proteasomal degradation of IKZF1/3. CRBN thalidmomide binding domain (TBD) was map
Autor:
Justin Simms, Li Ren, Victor H Jimenez-Zepeda, Jackie Babich, Peter Duggan, Ranjan Maity, Ines Tagoug, Paola Neri, Nizar J. Bahlis, Howie Wu, Jiri Slaby
Publikováno v:
Blood. 124:170-170
Background: Immunomodulatory (IMiDs) drugs are now recognized as modifiers of the degrons targeted by the CLR4-CRBN E3 ligase. Lenalidomide binding to CRBN promotes the proteasomal degradation to the B cell specific zinc finger transcription factors
Autor:
Paola Neri, Nizar J. Bahlis, Ines Tagoug, Jiri Slaby, Jacquelyn Babich, Justin Simms, Li Ren, Kathy Gratton
Publikováno v:
Blood. 122:3165-3165
Background Chromosomal region maintenance (CRM1), also known as exportin 1 (XPO1) plays an important role in the nuclear-cytoplasmic shuttling. The nuclear export receptor, XPO1, is considered as a regulator of subcellular distribution of several pro
Autor:
Justin Simms, Li Ren, Jiri Slaby, Paola Neri, Nizar J. Bahlis, Ines Tagoug, Jacquelyn Babich, Kathy Gratton
Publikováno v:
Blood. 122:3161-3161
Background Deregulation of ribosome biogenesis is associated with carcinogenesis and in MM two of the most common recurrent mutations (DIS3 and FAM46C) are implicated in ribosomal decay and translational control. Beside its role in the regulation of