Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Justin Serio"'
Autor:
James Ropa, Bridget Waas, Sierrah M. Grigsby, Andrew G. Muntean, Ivan Maillard, Zaneta Nikolovska-Coleska, Justin Serio, Chenxi Shen, Jennifer Chase, Ann Friedman
Publikováno v:
Cancers
Volume 13
Issue 4
Cancers, Vol 13, Iss 642, p 642 (2021)
Volume 13
Issue 4
Cancers, Vol 13, Iss 642, p 642 (2021)
Simple Summary MLL-rearranged leukemia, driven by MLL-fusion proteins, is an aggressive, therapy-resistant leukemia found in >60% of infant leukemia and ~10% of adult leukemia. Studies have shown that inhibiting DOT1L enzymatic activity blocks leukem
Autor:
James Ropa, Wei Chen, Zhiling Chen, Andrew G. Muntean, Venkatesha Basrur, Lili Zhao, Nirmalya Saha, Justin Serio, Dattatreya Mellacheruvu, Alexey I. Nesvizhskii
Publikováno v:
Oncotarget. 9:22123-22136
The Polymerase Associated Factor 1 complex (PAF1c) is an epigenetic co-modifying complex that directly contacts RNA polymerase II (RNAPII) and several epigenetic regulating proteins. Mutations, overexpression and loss of expression of subunits of the
Autor:
Jolanta Grembecka, James Ropa, Andrew G. Muntean, Wei Chen, Lili Chen, Tomasz Cierpicki, Justin Serio, Hongzhi Miao, Maria Mysliwski, Nirmalya Saha, Jingya Wang
Publikováno v:
Oncogene
Acute myeloid leukemia (AML) is a disease associated with epigenetic dysregulation. 11q23 translocations involving the H3K4 methyltransferase MLL1 (KMT2A) generate oncogenic fusion proteins with deregulated transcriptional potential. The Polymerase A
SETDB1 Mediated H3K9 Methylation Suppresses MLL-Fusion Target Expression and Leukemic Transformation
Autor:
Nirmalya Saha, Hsiangyu Hu, Venkatesha Basrur, James Ropa, Lili Zhao, Andrew G. Muntean, Ivan Maillard, Justin Serio, Alexei Nesvizhskii
Publikováno v:
Blood. 134:110-110
Genes encoding epigenetic proteins are mutated in about 70% of Acute Myeloid Leukemia patients underscoring their role in leukemic transformation. Epigenetic deregulation of the HOXA gene cluster drives transformation of about 50% of acute myeloid le
Autor:
James, Ropa, Nirmalya, Saha, Zhiling, Chen, Justin, Serio, Wei, Chen, Dattatreya, Mellacheruvu, Lili, Zhao, Venkatesha, Basrur, Alexey I, Nesvizhskii, Andrew G, Muntean
Publikováno v:
Oncotarget
The Polymerase Associated Factor 1 complex (PAF1c) is an epigenetic co-modifying complex that directly contacts RNA polymerase II (RNAPII) and several epigenetic regulating proteins. Mutations, overexpression and loss of expression of subunits of the
Autor:
Lili Chen, Andrew G. Muntean, Wei Chen, Maria Mysliwski, Ari Melnick, Ross L. Levine, James Ropa, Justin Serio, Zaneta Nikolovska-Coleska, Rebecca J. Chan, Jay P. Patel, Fardokht A. Abulwerdi, Martin S. Tallman, Omar Abdel-Wahab, Elisabeth Paietta
Publikováno v:
Leukemia
PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well defined in other neoplasms. Her
Autor:
Haying Sun, Ann Friedman, Ivan Maillard, Sierrah M. Grigsby, James Ropa, Bridget Waas, Justin Serio, Lei Du, Jennifer Chase, Zaneta Nikolovska-Coleska, Aihong Yao, Andrew G. Muntean
Publikováno v:
Cancer Research. 78:1380-1380
Leukemias harboring rearrangements of mixed-lineage leukemia gene (MLL1) are associated with poor clinical outcomes, and new therapeutic approaches are needed. Rearrangement of the MLL1 gene generates fusion oncoproteins which drive the high expressi
Autor:
Sierrah M. Grigsby, James Ropa, Ivan Maillard, Justin Serio, Andrew G. Muntean, Chenxi Shen, Jennifer Chase, Zaneta Nikolovska-Coleska
Publikováno v:
Cancer Research. 77:5489-5489
Mixed lineage leukemia (MLL) is an aggressive form of leukemia where the MLL gene is translocated and fused to more than 80 different nuclear, cytoplasmic and membrane proteins. MLL-AF9 is one of the most common MLL-fusions. This fusion partner is kn
Autor:
James Ropa, Maria Mysliwski, Jingya Wang, Wei Chen, Lili Chen, Justin Serio, Andrew G. Muntean
Publikováno v:
Blood. 128:3914-3914
Acute myeloid leukemias have been linked with dysregulated epigenetic landscapes sometimes attributed to altered functions of epigenetic regulators. The Polymerase-Associated Factor complex (PAFc) is an epigenetic regulator involved in transcriptiona
Autor:
James Ropa, Justin Serio, Preston S. Donover, Zaneta Nikolovska-Coleska, Melvin Reichman, Ivan Maillard, Andrew G. Muntean, Sierrah M. Grigsby, Martha J. Larsen, Chenxi Shen, Jennifer Chase
Publikováno v:
Cancer Research. 76:3803-3803
Leukemias harboring rearrangements of mixed-lineage leukemia gene (MLL1) are associated with poor clinical outcomes, and new therapeutic approaches are needed. Rearrangements of the MLL1 gene generate fusion oncoproteins which drive the high expressi