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pro vyhledávání: '"Justin S. Rodgers"'
Publikováno v:
Biochemical Pharmacology. 61:1543-1550
Mercury has harmful effects in both rodents and humans. In rodent tissue culture cells exposed to HgCl(2), the metal ions were observed to concentrate in cell nuclei and to associate with chromatin. Thus, transcription factors and other proteins asso
Autor:
Bruce A. Roe, Michael E. Dresser, Joan W. Conaway, Rodney J. Moreland, Ronald C. Conaway, Jay S. Hanas, Justin S. Rodgers
Publikováno v:
Nucleic acids research. 28(9)
Transcription factor IIIA (TFIIIA) activates 5S ribosomal RNA gene transcription in eukaryotes. The protein from vertebrates has nine contiguous Cys(2)His(2)zinc fingers which function in nucleic acid binding, and a C-terminal region involved in tran
Publikováno v:
Molecular pharmacology. 56(5)
The association of lead with chromatin in cells suggests that deleterious metal effects may in part be mediated through alterations in gene function. To elucidate if and how lead may alter DNA binding of cysteine-rich zinc finger proteins, lead ions