Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Justin S. Potuzak"'
1
The 2010 Benjamin Franklin medal in chemistry presented to Joanne Stubbe
Autor: Amos B. Smith, Justin S. Potuzak
Publikováno v: Journal of the Franklin Institute. 351:1-11
For pioneering studies demonstrating that ribonucleotide reductases transform ribonucleotides into deoxyribonucleotides by an astonishing free-radical mechanism and for her unprecedented achievements in the study of complex biological systems through
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::485ac6429b37571e651e8f2625ba593a
https://doi.org/10.1016/j.jfranklin.2012.12.003
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2
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies
Autor: Amos B. Smith, Michael J. James, Justin S. Potuzak, Virginia M.-Y. Lee, Yuemang Yao, Anne-Marie L. Hogan, Nuria Ibarz Ferrer, Kurt R. Brunden, Carlo Ballatore, John Q. Trojanowski
Publikováno v: Pharmacological Research. 63:341-351
Tau, a protein that is enriched in neurons of the central nervous system (CNS), is thought to play a critical role in the stabilization of microtubules (MTs). Several neurodegenerative disorders referred to as tauopathies, including Alzheimer's disea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3ec88c5beb70ea0a305ac8415ae6bc
https://doi.org/10.1016/j.phrs.2010.12.002
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3
Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
Autor: Sharon X. Xie, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Justin S. Potuzak, Michiyo Iba, Yuemang Yao, Michael J. James, John Q. Trojanowski, Bin Zhang, Anne-Marie L. Hogan, Jenna C. Carroll, Kurt R. Brunden
Publikováno v: The Journal of Neuroscience. 30:13861-13866
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau misfolding could l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af62b622af867c277f9dfffe5f20e43
https://doi.org/10.1523/jneurosci.3059-10.2010
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5
Synthesis of C1-alkyl- and acylglycals from glycals using a B-alkyl Suzuki–Miyaura cross coupling approach
Autor: Justin S. Potuzak, Derek S. Tan
Publikováno v: Tetrahedron Letters. 45:1797-1801
A B-alkyl Suzuki–Miyaura cross coupling approach provides a flexible, efficient means to convert glycals to C1-alkylglycals and C1-acylglycals that are versatile synthetic intermediates. This approach uses readily available glycal starting material
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::585db321c1e2752c50817aeca99e0c25
https://doi.org/10.1016/j.tetlet.2003.12.006
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6
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
Autor: Amos B. Smith, Virginia M.-Y. Lee, Jenna C. Carroll, Kurt R. Brunden, Yuemang Yao, Michiyo Iba, Justin S. Potuzak, Bin Zhang, Anne-Marie L. Hogan, John Q. Trojanowski, Sharon X. Xie, Carlo Ballatore
Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11)
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased phosphorylation and decreased solubility has been proposed to diminish normal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf12f38244786670374fb2e1bab68cc9
https://pubmed.ncbi.nlm.nih.gov/22423084
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7
Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues
Autor: John M. Streicher, William A. Carlezon, Bruce M. Cohen, Lee-Yuan Liu-Chen, Laura M. Bohn, Justin S. Potuzak, Chad E. Groer, Cécile Béguin, Wei Xu
Publikováno v: Bioorganicmedicinal chemistry letters. 22(2)
The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db31ae2ef94c888c4748c3a815694cc
https://pubmed.ncbi.nlm.nih.gov/22204910
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8
A Formal Total Synthesis of (-)-Brevisamide
Autor: Justin S. Potuzak, Amos B. Smith, Noriki Kutsumura
Publikováno v: Tetrahedron letters. 52(17)
A formal total synthesis of (−)-brevisamide has been achieved. The synthetic approach highlights a chemoselective asymmetric dihydroxylation and a one-pot Fraser-Reid epoxidation/PMB protection reaction sequence.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d44b795179689b38833b77c0408d41c
https://pubmed.ncbi.nlm.nih.gov/21572531
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10
Stereocontrolled Synthesis of Spiroketals via a Remarkable Methanol-Induced Kinetic Spirocyclization Reaction
Autor: Justin S. Potuzak, Sirkka B. Moilanen, Derek S. Tan
Publikováno v: ChemInform. 37
A methanol-induced kinetic spiroketalization reaction has been developed for the stereocontrolled target- and diversity-oriented synthesis of spiroketals. In contrast to existing methods for spiroketal synthesis, this reaction does not depend on ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa828f67c2bc1e8d42db742773d269
https://doi.org/10.1002/chin.200609138
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