Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study

Autor: Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson, Yakeel T. Quiroz

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2021)

Abstract Background Neuroimaging studies of autosomal dominant Alzheimer’s disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rat

Externí odkaz: https://doaj.org/article/6c7078c506f2419da4f7a232e1dfe210

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

Autor: Francisco Lopera, Claudia Marino, Anita S. Chandrahas, Michael O’Hare, Nelson David Villalba-Moreno, David Aguillon, Ana Baena, Justin S. Sanchez, Clara Vila-Castelar, Liliana Ramirez Gomez, Natalia Chmielewska, Gabriel M. Oliveira, Jessica Lisa Littau, Kristin Hartmann, Kyungeun Park, Susanne Krasemann, Markus Glatzel, Dorothee Schoemaker, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Said Arevalo-Alquichire, Kahira L. Saez-Torres, Dhanesh Amarnani, Leo A. Kim, Randall C. Mazzarino, Harper Gordon, Yamile Bocanegra, Andres Villegas, Xiaowu Gai, Moiz Bootwalla, Jianling Ji, Lishuang Shen, Kenneth S. Kosik, Yi Su, Yinghua Chen, Aaron Schultz, Reisa A. Sperling, Keith Johnson, Eric M. Reiman, Diego Sepulveda-Falla, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz

Publikováno v: Nature Medicine. 29:1243-1252

We characterized the world’s second case with ascertained extreme resilience to autosomal dominant Alzheimer’s disease (ADAD). Side-by-side comparisons of this male case and the previously reported female case with ADAD homozygote for the APOE3 C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbe347616c0af69e09ef1427cfb6ea9e
https://doi.org/10.1038/s41591-023-02318-3

Cortical thickness across the lifespan in a Colombian cohort with autosomal‐dominant Alzheimer's disease: A cross‐sectional study

Autor: Joshua T. Fox‐Fuller, Heirangi Torrico‐Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán‐Vélez, Clara Vila‐Castelar, Daniel C. Aguirre‐Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa‐Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)

Abstract Introduction Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age‐related trajectory of cortical thickness across the lifespan (9‐59 years) in a Colombian kindred with autosomal dominant

Externí odkaz: https://doaj.org/article/7a9a5af90bbf4517bba4147eb850487d

Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults

Autor: Matthew R. Scott, Olivia L. Hampton, Rachel F. Buckley, Jasmeer P. Chhatwal, Bernard J. Hanseeuw, Heidi IL. Jacobs, Michael J. Properzi, Justin S. Sanchez, Keith A. Johnson, Reisa A. Sperling, Aaron P. Schultz

Publikováno v: NeuroImage, Vol 220, Iss , Pp 116991- (2020)

Neurofibrillary tau tangles are a hallmark pathology of Alzheimer's disease (AD) and are more closely associated with AD-related cortical atrophy and symptom severity than amyloid-beta (Aβ). However, studies regarding the effect of tau on longitudin

Externí odkaz: https://doaj.org/article/e277ebee1046491c8973965075c1da79

Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study

Autor: Heidi I.L. Jacobs, Adrienne O’Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Bernard J. Hanseeuw, Emma Thibault, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri

Publikováno v: Journal of Alzheimer's disease : JAD, vol 86, iss 4
Journal of Alzheimer's disease : JAD, Vol. 86, no.4, p. 1603-1609 (2022)
Journal of Alzheimer's Disease, Vol. 86, no. 4, p. 1603-1609 (2022)
J Alzheimers Dis
Journal of Alzheimer's Disease, 86(4), 1603-1609. IOS Press

The brainstem is among the first regions to accumulate Alzheimer’s disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 mid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79740b0fd26984c4370dd6ce55519cb5
https://cris.maastrichtuniversity.nl/en/publications/81dc20d4-8165-48e4-9560-1d89400ffd23