Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Justin Raymond Hamilton"'
Autor:
Sophia Xie, Paul Lacaze, Justin Raymond Hamilton, Maria V. Selvadurai, Moeen Riaz, John J McNeil, Andrew Tonkin
Publikováno v:
Thrombosis and haemostasis. 122(7)
Background Protease-activated receptor 4 (PAR4) is a platelet thrombin receptor important for thrombosis and a target of antiplatelet drug development. A frequently occurring single-nucleotide polymorphism (rs773902) causes a PAR4 sequence variant (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a46ac250c15cff9ca71b2be02a8ade5
https://pubmed.ncbi.nlm.nih.gov/34852379
https://pubmed.ncbi.nlm.nih.gov/34852379
Autor:
Rithwik Ramachandran, Kathryn DeFea, Nigel W. Bunnett, JoAnn Trejo, Morley D. Hollenberg, Justin Raymond Hamilton
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Proteinase-activated receptors (PARs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Proteinase-activated Receptors [39]) are unique members of the GPCR superfamily activated by proteolytic cleavage of their amino terminal exodomains. Agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24786b9ec80fcfbbe9058275406e264f
https://doi.org/10.2218/gtopdb/f59/2021.3
https://doi.org/10.2218/gtopdb/f59/2021.3
Autor:
Diego Chacon, Sung K. Chiu, David J. Curtis, Mitchell J. Moon, Stephanie L. Orive, Justin Raymond Hamilton, Cedric S. Tremblay, John E. Pimanda, Dominik Beck, Benjamin T. Kile, Sarah Ellis, Yizhou Huang, Jesslyn Saw
Publikováno v:
Blood. 134:826-835
The stem cell leukemia (Scl or Tal1) protein forms part of a multimeric transcription factor complex required for normal megakaryopoiesis. However, unlike other members of this complex such as Gata1, Fli1, and Runx1, mutations of Scl have not been ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f43754370f32a2fbe314b63d983459
https://doi.org/10.1182/blood.2019896175
https://doi.org/10.1182/blood.2019896175
Autor:
Mitchell J. Moon, Arnan Mitchell, Warwick Scott Nesbitt, Rose J. Brazilek, Charitha de Silva, Ivan Marusic, Crispin Szydzik, Harshal Hanumant Nandurkar, Andrew Ooi, Farzan Akbaridoust, Justin Raymond Hamilton
Publikováno v:
Analytical Chemistry. 91:10830-10839
There is a need for scalable automated lab-on-chip systems incorporating precise hemodynamic control that can be applied to high-content screening of new more efficacious antiplatelet therapies. This paper reports on the development and characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e152e0c2cb6a310ef39591cd25236798
https://doi.org/10.1021/acs.analchem.9b02486
https://doi.org/10.1021/acs.analchem.9b02486
Autor:
Chris Ward, Anna Bogdanova, Maggie L. Kalev-Zylinska, James I. Hearn, Marie-Christine Morel-Kopp, Justin Raymond Hamilton
Publikováno v:
Platelets. 32(8)
Ionotropic glutamate receptors include α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), kainate receptors (KAR), and N-methyl-D-aspartate receptors (NMDAR). All function as c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0383ab3ecd45f98f31ee9d4d1a017094
https://pubmed.ncbi.nlm.nih.gov/33284715
https://pubmed.ncbi.nlm.nih.gov/33284715
Publikováno v:
Platelets. 32(7)
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab2ca3ff88730d040d801a2150fd4b
https://pubmed.ncbi.nlm.nih.gov/32819173
https://pubmed.ncbi.nlm.nih.gov/32819173
Autor:
Anita Eckly, Mitchell J. Moon, Christian Gachet, Jean Yves Rinckel, Harshal Hanumant Nandurkar, Peter J. Meikle, Justin Raymond Hamilton, Maria V. Selvadurai, Rose J. Brazilek, Warwick Scott Nesbitt
Publikováno v:
FEBS Letters. 593:88-96
PI3KC2α is a phosphoinositide 3-kinase with a recently reported function in platelets; PI3KC2α-deficient mouse platelets have altered membrane structure and impaired function. Yet, how these membrane changes cause platelet dysfunction remains unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec44d868f452b93aeada468d6fd23185
https://doi.org/10.1002/1873-3468.13295
https://doi.org/10.1002/1873-3468.13295
Autor:
Mitchell J. Moon, Rose J. Brazilek, Justin Raymond Hamilton, Charitha de Silva, Farzan Akbaridoust, Harshal Hanumant Nandurkar, Arnan Mitchell, Ivan Marusic, Warwick Scott Nesbitt, Crispin Szydzik
Publikováno v:
SPIE Micro + Nano Materials, Devices, and Applications 2019.
This work reports on development and characterization of an on-chip microfluidic handling system for application in preclinical anti-platelet drug screening. A reciprocating elastomeric micropump/mixer design is presented for use with whole human blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c412e9e984bdcda911aaca98ed700a9
https://doi.org/10.1117/12.2541102
https://doi.org/10.1117/12.2541102
Autor:
Justin Raymond Hamilton, Rithwik Ramachandran, JoAnn Trejo, Nigel W. Bunnett, Kathryn DeFea, Morley D. Hollenberg
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Proteinase-activated receptors (PARs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Proteinase-activated Receptors [35]) are unique members of the GPCR superfamily activated by proteolytic cleavage of their amino terminal exodomains. Agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c3e77674078f0832c519da25e81582
https://doi.org/10.2218/gtopdb/f59/2019.4
https://doi.org/10.2218/gtopdb/f59/2019.4
Autor:
Maria V. Selvadurai, Aleksandra Adamska, Krithika Sundaram, Justin Raymond Hamilton, Philip E. Thompson, Marco Falasca
Publikováno v:
Journal of Medicinal Chemistry. 60:47-65
The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases central to regulating a wide range of important intracellular processes. Despite the vast knowledge around class I PI3Ks, the class II PI3Ks have been neglected, seemingly only due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91e7cdbb6ad2849fc40c4d9c6e4c9912
https://doi.org/10.1021/acs.jmedchem.6b00963
https://doi.org/10.1021/acs.jmedchem.6b00963