Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Justin R. Sysol"'
Autor:
Jiwang Chen, Angelia Lockett, Shuangping Zhao, Long Shuang Huang, Yifan Wang, Weiwen Wu, Ming Tang, Shahzaib Haider, Daniela Velez Rendon, Raheel Khan, Bing Liu, Nicholas Felesena, Justin R. Sysol, Daniela Valdez-Jasso, Haiyang Tang, Yang Bai, Viswanathan Natarajan, Roberto F. Machado
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14516 (2022)
Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an important stimulus for pulmonary artery smooth muscle cell (PASMC) proliferation a
Externí odkaz:
https://doaj.org/article/c3880120feaa46878a9dffa6844bde9f
Autor:
Carles Lerin, Allison B. Goldfine, Tanner Boes, Manway Liu, Simon Kasif, Jonathan M. Dreyfuss, Ana Luisa De Sousa-Coelho, Grace Daher, Irini Manoli, Justin R. Sysol, Elvira Isganaitis, Niels Jessen, Laurie J. Goodyear, Kirk Beebe, Walt Gall, Charles P. Venditti, Mary-Elizabeth Patti
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 926-936 (2016)
Objective: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains u
Externí odkaz:
https://doaj.org/article/4be0d7d9bd0947dc91ff7cebd1442b54
Autor:
Nicole M. Jones, Justin R. Sysol, Sunit Singla, Patricia Smith, George E. Sandusky, Huashan Wang, Viswanathan Natarajan, Steven M. Dudek, Roberto F. Machado
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
In patients with sickle cell disease (SCD), acute chest syndrome (ACS) is a common form of acute lung injury and a major cause of morbidity and mortality. The pathophysiology of ACS is complex, and hemin, the prosthetic moiety of hemoglobin, has been
Autor:
Justin R. Sysol, Roberto Machado
Publikováno v:
Continuing Cardiology Education. 4:2-12
Autor:
Jiwang Chen, Suzy A. A. Comhair, Shuangping Zhao, Viswanathan Natarajan, Justin R. Sysol, Roberto Machado, Sunit Singla
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 314:L461-L472
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined. In this study, we sought to characterize the
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:307-314
Hemin, the oxidized prosthetic moiety of hemoglobin, has been implicated in the pathogenesis of acute chest syndrome in patients with sickle cell disease by virtue of its endothelial-activating properties. In this study, we examined whether hemin can
Autor:
Jonathan M. Dreyfuss, Manway Liu, Niels Jessen, Walt Gall, Tanner Boes, Irini Manoli, Elvira Isganaitis, Carles Lerin, Grace Daher, Simon Kasif, Kirk Beebe, Mary-Elizabeth Patti, Charles P. Venditti, Justin R. Sysol, Ana Luísa De Sousa-Coelho, Allison B. Goldfine, Laurie J. Goodyear
Publikováno v:
Molecular Metabolism
Lerin, C, Goldfine, A B, Boes, T, Liu, M, Kasif, S, Dreyfuss, J M, De Sousa-Coelho, A L, Daher, G, Manoli, I, Sysol, J R, Isganaitis, E, Jessen, N, Goodyear, L J, Beebe, K, Gall, W, Venditti, C P & Patti, M-E 2016, ' Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism ', Molecular Metabolism, vol. 5, no. 10, pp. 926-36 . https://doi.org/10.1016/j.molmet.2016.08.001
Molecular Metabolism, Vol 5, Iss 10, Pp 926-936 (2016)
Lerin, C, Goldfine, A B, Boes, T, Liu, M, Kasif, S, Dreyfuss, J M, De Sousa-Coelho, A L, Daher, G, Manoli, I, Sysol, J R, Isganaitis, E, Jessen, N, Goodyear, L J, Beebe, K, Gall, W, Venditti, C P & Patti, M-E 2016, ' Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism ', Molecular Metabolism, vol. 5, no. 10, pp. 926-36 . https://doi.org/10.1016/j.molmet.2016.08.001
Molecular Metabolism, Vol 5, Iss 10, Pp 926-936 (2016)
Objective Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains un
Autor:
Jiwang Chen, Stefan Offermanns, Justin R. Sysol, Ayako Makino, Richard D. Ye, Marcelo G. Bonini, Dustin R. Fraidenburg, Richard D. Minshall, Abigail Drennan, Shanshan Song, Roberto F. Machado, Haiyang Tang, Jason X.-J. Yuan, Joe G.N. Garcia
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 308:L208-L220
Pulmonary vascular remodeling, mainly attributable to enhanced pulmonary arterial smooth muscle cell proliferation and migration, is a major cause for elevated pulmonary vascular resistance and pulmonary arterial pressure in patients with pulmonary h
Autor:
Alexandru Susma, Justin R. Sysol, Ashok K. Singh, Xu Zhang, Suman Setty, Victor R. Gordeuk, Santosh L. Saraf, Krishnamurthy P. Gudehithlu, Roberto F. Machado, Jose A.L. Arruda
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 197
Homozygosity for the hemoglobin (Hb) S mutation (HbSS, sickle cell anemia) results in hemoglobin polymerization under hypoxic conditions leading to vaso-occlusion and hemolysis. Sickle cell anemia affects 1:500 African Americans and is a strong risk
Autor:
Jiwang Chen, Aya Yamamura, Daniela Valdez-Jasso, Jaime Torres, Arvind Sridhar, Shui Quing Ye, Sara M. Camp, Jason X.-J. Yuan, Krystyna M. Shioura, Sunit Singla, Shuangping Zhao, Sakshi Sahni, Suzy A. A. Comhair, Taimur Abbasi, Roberto F. Machado, Justin R. Sysol, Hui Gao, Raed A. Dweik, Haiyang Tang, Joe G.N. Garcia, Paul M. Hassoun, Vamsi Reddy
Background:Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT) is a cytozyme that regulates intracellular nicotinamide adenine dinuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556ddeba969cc0db9ad7bfa80b76ac5b
https://europepmc.org/articles/PMC5400780/
https://europepmc.org/articles/PMC5400780/