Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Justin R. Siebert"'
Autor:
Kristen Swieck, Amanda Conta-Steencken, Frank A. Middleton, Justin R. Siebert, Donna J. Osterhout, Dennis J. Stelzner
Publikováno v:
BMC Neuroscience, Vol 20, Iss 1, Pp 1-20 (2019)
Abstract Background The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration after spinal cord injury.
Externí odkaz:
https://doaj.org/article/ad2e13a35f5f4168b0c3847550a8c5f1
Autor:
Justin R. Siebert, Donna J. Osterhout
Publikováno v:
Journal of Neuroscience Research
Axonal damage and the subsequent interruption of intact neuronal pathways in the spinal cord are largely responsible for the loss of motor function after injury. Further exacerbating this loss is the demyelination of neighboring uninjured axons. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbc872615c4914af4157763a85eba46
https://doi.org/10.1002/jnr.24780
https://doi.org/10.1002/jnr.24780
Publikováno v:
HAPS Educator. 23:488-498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e5f5e720c00f7fb4dca7cae768d2b2
https://doi.org/10.21692/haps.2019.026
https://doi.org/10.21692/haps.2019.026
Autor:
Frank A. Middleton, Dennis J. Stelzner, Amanda Conta-Steencken, Justin R. Siebert, Donna J. Osterhout, Kristen Swieck
Publikováno v:
BMC Neuroscience
BMC Neuroscience, Vol 20, Iss 1, Pp 1-20 (2019)
BMC Neuroscience, Vol 20, Iss 1, Pp 1-20 (2019)
Background The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration after spinal cord injury. They can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd398203fd118cdc5ec9dd2875a39185
http://europepmc.org/articles/PMC6421714
http://europepmc.org/articles/PMC6421714
Autor:
Justin R. Siebert, Donna J. Osterhout
Publikováno v:
Journal of Neurochemistry. 119:176-188
J. Neurochem. (2011) 119, 176–188. Abstract The formation of the glial scar following a spinal cord injury presents a significant barrier to the regenerative process. It is primarily composed of chondroitin sulfate proteoglycans (CSPGs) that can in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0324f9d5a02bb37f4c2355c514a816
https://doi.org/10.1111/j.1471-4159.2011.07370.x
https://doi.org/10.1111/j.1471-4159.2011.07370.x
Autor:
Justin R. Siebert, Donna J. Osterhout
Publikováno v:
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 294:759-763
Oligodendrocyte (OL) progenitor cells (OPCs) give rise to the myelinating cells of the central nervous system (CNS), the OL. To examine molecular changes involved in OPC differentiation, a microarray analysis was performed at several time points duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4658cd1a53b5df48ad9085464f9d6b9f
https://doi.org/10.1002/ar.21370
https://doi.org/10.1002/ar.21370
Publikováno v:
BioMed Research International, Vol 2015 (2015)
BioMed Research International
BioMed Research International
While advances in technology and medicine have improved both longevity and quality of life in patients living with a spinal cord injury, restoration of full motor function is not often achieved. This is due to the failure of repair and regeneration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142c1cda214a9b3421f17831d0a94d52
https://doaj.org/article/9c413b6b34c94c22af7b88f1fc1bfcba
https://doaj.org/article/9c413b6b34c94c22af7b88f1fc1bfcba
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2014 (2014)
BioMed Research International, Vol 2014 (2014)
Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult. With injury or disease, an increase in CSPG expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c5dcdf39cf6ca0d3e424b4e88e202e
http://europepmc.org/articles/PMC4182688
http://europepmc.org/articles/PMC4182688
Publikováno v:
Experimental neurology. 231(1)
Following spinal cord injury (SCI), the demyelination of spared intact axons near the lesion site likely contributes to the loss of motor function. This demyelination occurs when oligodendrocytes, the myelinating cells of the central nervous system (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ee4657679640aa80d7c055c1e9645f
https://pubmed.ncbi.nlm.nih.gov/21596037
https://pubmed.ncbi.nlm.nih.gov/21596037
Publikováno v:
BMC Neuroscience
BMC Neuroscience, Vol 11, Iss 1, p 148 (2010)
BMC Neuroscience, Vol 11, Iss 1, p 148 (2010)
Background Propriospinal neurons, with axonal projections intrinsic to the spinal cord, have shown a greater regenerative response than supraspinal neurons after axotomy due to spinal cord injury (SCI). Our previous work focused on the response of ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d1ec9e8c8c13cb73e8a24630a90e82
https://pubmed.ncbi.nlm.nih.gov/21092315
https://pubmed.ncbi.nlm.nih.gov/21092315