Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Justin R. Prigge"'
Autor:
Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2771-2781 (2017)
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively,
Externí odkaz:
https://doaj.org/article/608638e94517493f8c9dd7af8d0965f9
Autor:
Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 359 (2021)
Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine cataboli
Externí odkaz:
https://doaj.org/article/98510a8d188d4921848458dea2409ac7
Autor:
Kelly M. Shepardson, Kyle Larson, Rachelle V. Morton, Justin R. Prigge, Edward E. Schmidt, Victor C. Huber, Agnieszka Rynda-Apple
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT Bacterial superinfections are a primary cause of death during influenza pandemics and epidemics. Type I interferon (IFN) signaling contributes to increased susceptibility of mice to bacterial superinfection around day 7 post-influenza A viru
Externí odkaz:
https://doaj.org/article/82538702d9634950a37811b419608ec6
Autor:
Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Publikováno v:
Cancer Research.
Mutations in the KEAP1-NRF2 pathway occur in up to a third of non-small cell lung cancer (NSCLC) cases and often confer resistance to therapy and poor outcomes. Here, we developed murine alleles of the KEAP1 and NRF2 mutations found in human NSCLC an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae3853e773043b56e380c1c93c1e3c2
https://doi.org/10.1158/0008-5472.can-22-3848
https://doi.org/10.1158/0008-5472.can-22-3848
Autor:
Emily A. Talago, Luke O. Brandenberger, Michael R. McLoughlin, Rachel A. Sabol, Elias S.J. Arnér, Sonya V. Iverson, Pushya Krishna, David J. Orlicky, Sofi Eriksson, Colin T. Shearn, Colin G. Miller, Brian Bothner, Ian Cavigli, Volkan I. Sayin, Edward E. Schmidt, Jean A. Kundert, Thales Papagiannakopoulos, Joshua Heinemann, Justin R. Prigge
Publikováno v:
Proceedings of the National Academy of Sciences. 116:11408-11417
Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven antioxidant systems form an integrated network that combats potentially carcinogenic oxidative damage yet also protects cancer cells from oxidative d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7069351afcb46922b93ce62ceca1f81b
https://doi.org/10.1073/pnas.1903244116
https://doi.org/10.1073/pnas.1903244116
Autor:
Takaaki Akaike, Edward E. Schmidt, Justin R. Prigge, Elias S.J. Arnér, Tsuyoshi Takata, Tomoaki Ida, N. Balog, Yosuke Funato, Péter Nagy, Yoshito Kumagai, Qing Cheng, Hiroaki Miki, Yumi Abiko, Markus Dagnell, Éva Dóka, Akira Nishimura, Jon M. Fukuto, B. Espinosa, Nho Cong Luong
Publikováno v:
Science Advances
Thioredoxin system–mediated persulfidation of Cys residues controls protein function and protects them from oxidative stress.
Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein function. We found that p
Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein function. We found that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d74dcb8f21de4b41ff1696098d32bea
https://doi.org/10.1126/sciadv.aax8358
https://doi.org/10.1126/sciadv.aax8358
Autor:
Angela Davies, Sarah E. LeBoeuf, Francisco J. Sánchez-Rivera, Triantafyllia R. Karakousi, Igor Dolgalev, Tyler Jacks, Matthew G. Vander Heiden, Volkan I. Sayin, Adriana Heguy, Justin R. Prigge, Lakshmipriya Subbaraj, Donald C Ellis, John T. Poirier, Edward E. Schmidt, Roderick T. Bronson, Arjun Bhutkar, Craig J. Thomas, Rodrigo Romero, Viola Allaj, Shawn M. Davidson, Andre L. Moreira, Britney Martinez, Thales Papagiannakopoulos, Matthew R. Bauer, Chandra Goparaju, Harvey I. Pass, Simranjit X. Singh, Charles M. Rudin
Publikováno v:
Nature medicine
Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c34661db12d1447a2ebef0e4ceead98
https://doi.org/10.1038/nm.4407
https://doi.org/10.1038/nm.4407
Autor:
Fernando T. Ogata, Michael D. Bruschwein, Matthew P. Taylor, Edward E. Schmidt, Justin R. Prigge, Elias S.J. Arnér, Sebastin S. Martin, Åse Mattsson, Colin T. Shearn, Jean A. Kundert, Lucia Coppo, Alix E. Herr, Tomas N. Gustafsson, Julia Lytchier, Arne Holmgren, Colin G. Miller, David J. Orlicky
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2771-2781 (2017)
Cell reports
Cell reports
SUMMARY Energetic nutrients are oxidized to sustain high intra-cellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5871e7279eee5df7c602a561f74d74
http://www.sciencedirect.com/science/article/pii/S2211124717308161
http://www.sciencedirect.com/science/article/pii/S2211124717308161
Autor:
Wenjun Li, Xin Chen, Yao Liu, Xiaoxin Luke Chen, Zheng Sun, Justin R. Prigge, Xinyan Zhang, Olesya Palko, Aixian Lan, Zhaohui Xiong, Edward E. Schmidt, Shanshan Zhou, Hao Chen, Mayanga Kapita
Publikováno v:
Oncotarget
// Aixian Lan 1, * , Wenjun Li 1, * , Yao Liu 1 , Zhaohui Xiong 2 , Xinyan Zhang 1 , Shanshan Zhou 3 , Olesya Palko 2 , Hao Chen 2 , Mayanga Kapita 2 , Justin R. Prigge 4 , Edward E. Schmidt 4 , Xin Chen 3 , Zheng Sun 1 , Xiaoxin Luke Chen 2 1 Depart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7758ff70ef131911eec9ff0928bb3b47
http://europepmc.org/articles/PMC5288201
http://europepmc.org/articles/PMC5288201
Autor:
Xiaoxin Chen, Hong Fan, Edward E. Schmidt, Justin R. Prigge, Zheng Sun, Xinyan Zhang, Chorlada Paiboonrungruan
Oxidative stress is known to play a pivotal role in the development of oral squamous cell carcinoma (OSCC). We have demonstrated that activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway has chemopreventive effects a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4951b7da45a3e9e127fb5e467fadb150
https://europepmc.org/articles/PMC6037169/
https://europepmc.org/articles/PMC6037169/
