Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Justin R. Porter"'
Autor:
Matthew A. Cruz, Thomas E. Frederick, Upasana L. Mallimadugula, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola vir
Externí odkaz:
https://doaj.org/article/b1138d9e9bae403da917984ac9c6ee9b
Publikováno v:
eLife, Vol 9 (2020)
Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However,
Externí odkaz:
https://doaj.org/article/a55697cfd1e6486e9b1c8264c308fb3b
Autor:
Yingye Fang, Thomas P. Burris, Antonina I. Frolova, P. I. Imoukhuede, Sarah K. England, Michael D. Ward, Thomas Koelblen, Gregory R. Bowman, Maxwell I. Zimmerman, Justin R. Porter, Manasi Malik, Michelle Roh
Publikováno v:
ACS Pharmacology & Translational Science. 4:1543-1555
The hormone oxytocin is commonly administered during childbirth to initiate and strengthen uterine contractions and prevent postpartum hemorrhage. However, patients have wide variation in the oxytocin dose required for a clinical response. To begin t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2abf014234762401fa66e4042c4328
https://doi.org/10.1021/acsptsci.1c00095
https://doi.org/10.1021/acsptsci.1c00095
Autor:
Sukrit Singh, Catherine E. Kuhn, Aoife M. Harbison, Vincent A. Voelz, John D. Chodera, Justin R. Porter, Neha Vithani, Joseph E. Coffland, Rafal P. Wiewiora, Artur Meller, Carl A Fogarty, Maxwell I. Zimmerman, Jonathan H. Borowsky, Gregory R. Bowman, Michael D. Ward, Matthew F. D. Hurley, Elisa Fadda, Upasana L. Mallimadugula
Publikováno v:
Nature Chemistry. 13:651-659
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression and replication that depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616c72101f8be9aa1b5000974b96797a
https://doi.org/10.1038/s41557-021-00707-0
https://doi.org/10.1038/s41557-021-00707-0
Autor:
Sukrit Singh, Gregory R. Bowman, Neha Vithani, Thomas E. Frederick, Maxwell I. Zimmerman, Matthew A. Cruz, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Upasana L. Mallimadugula
Publikováno v:
Nature communications. 13(1)
Protein-protein and protein-nucleic acid interactions are often considered difficult drug targets because the surfaces involved lack obvious druggable pockets. Cryptic pockets could present opportunities for targeting these interactions, but identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9515edf7ff74025634ed131311a4bafc
https://pubmed.ncbi.nlm.nih.gov/35477718
https://pubmed.ncbi.nlm.nih.gov/35477718
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138220 (2015)
A core task in computational structural biology is the search of conformational space for low energy configurations of a biological macromolecule. Because conformational space has a very high dimensionality, the most successful search methods integra
Externí odkaz:
https://doaj.org/article/67689dfdb0c04162b6dfdfe99e7b647a
Autor:
Michael J. Greenberg, Kathryn M. Hart, Justin R. Porter, Carrie A. Sibbald, Katelyn E. Moeder, Maxwell I. Zimmerman, Gregory R. Bowman
Publikováno v:
Biophysical Journal. 116:818-830
Proteins are dynamic molecules that undergo conformational changes to a broad spectrum of different excited states. Unfortunately, the small populations of these states make it difficult to determine their structures or functional implications. Compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af54a9195ca4506e7e429bf9709ec72
https://doi.org/10.1016/j.bpj.2018.11.3144
https://doi.org/10.1016/j.bpj.2018.11.3144
Autor:
Sukrit Singh, Rafal P. Wiewiora, John D. Chodera, Upasana L. Mallimadugula, Aoife M. Harbison, Maxwell I. Zimmerman, Jonathan H. Borowsky, Vincent A. Voelz, Matthew F. D. Hurley, Neha Vithani, Carl A Fogarty, Elisa Fadda, Gregory R. Bowman, Catherine E. Kuhn, Justin R. Porter, Joseph E. Coffland, Michael D. Ward, Artur Meller
Publikováno v:
Nature chemistry
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression, and replication, which depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95257af65179851fa72f91112ad7fd25
https://pubmed.ncbi.nlm.nih.gov/34031561
https://pubmed.ncbi.nlm.nih.gov/34031561
Autor:
Michael J. Greenberg, Artur Meller, Gregory R. Bowman, Justin R. Porter, Maxwell I. Zimmerman
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50d1b6fe8297bbce2680c8266f791b1
https://elifesciences.org/articles/55132
https://elifesciences.org/articles/55132
