Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Justin R. Nickell"'
Autor:
Venumadhav Janganati, Linda P. Dwoskin, Emily R. Hankosky, Justin R. Nickell, Shyam R. Joolakanti, Peter A. Crooks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5467-5472
A small library of fluoroethoxy-1,4-diphenethyl piperidine and fluoroethoxy-1,4-diphenethyl piperazine derivatives were designed, synthesized and evaluated for their ability to inhibit [3H]dopamine (DA) uptake at the vesicular monoamine transporter-2
Autor:
Keith D. Green, Sylvie Garneau-Tsodikova, Linda P. Dwoskin, Liliia M. Kril, Sanjib K. Shrestha, Stefan Kwiatkowski, Vitaliy M. Sviripa, Justin R. Nickell, David S. Watt
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:58-66
The emergence of multidrug-resistant bacterial and fungal strains poses a threat to human health that requires the design and synthesis of new classes of antimicrobial agents. We evaluated bis( N -amidinohydrazones) and N -(amidino)- N′ -aryl-bishy
Autor:
Guangrong Zheng, Venumadhav Janganati, John P. Culver, Linda P. Dwoskin, Peter A. Crooks, Justin R. Nickell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4441-4445
A small library of 1,4-diphenethylpiperazine analogs was synthesized and evaluated for inhibition of [3H]dihydrotetrabenazine binding and [3H]dopamine uptake at the vesicular monoamine transporter-2 (VMAT2). Results from these studies identified thre
Autor:
Justin R. Nickell, Venumadhav Janganati, Linda P. Dwoskin, John P. Culver, Guangrong Zheng, Peter A. Crooks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2997-3000
A series of 1,4-diphenalkylpiperidine analogs were synthesized and evaluated for their affinity and inhibitory potency at the [3H]dihydrotetrabenazine (DTBZ) binding site and [3H]dopamine (DA) uptake site on the vesicular monoamine transporter-2 (VMA
Autor:
Shyamsunder R. Joolakanti, Linda P. Dwoskin, Guangrong Zheng, Peter A. Crooks, Justin R. Nickell, Venumadhav Janganati
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2422-2427
A series of lobelane and GZ-793A analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [(3)H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and the do
Autor:
Ravshan Burikhanov, David S. Watt, Josiah M. Obiero, Justin R. Nickell, Chang-Guo Zhan, Oleg V. Tsodikov, Linda P. Dwoskin, Vitaliy M. Sviripa, Chunming Liu, Vivek M. Rangnekar, Yaxia Yuan
Publikováno v:
Organic & Biomolecular Chemistry. 14:74-84
Advanced prostate tumors usually metastasize to the lung, bone, and other vital tissues and are resistant to conventional therapy. Prostate apoptosis response-4 protein (Par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2613-2616
We have previously shown that quinolyl moieties are attractive structural replacements for the phenyl groups in lobelane. These quinolyl analogues had improved water-solubility over lobelane and retained the potent vesicular monoamine transporter-2 (
Autor:
Emily R, Hankosky, Shyam R, Joolakanti, Justin R, Nickell, Venumadhav, Janganati, Linda P, Dwoskin, Peter A, Crooks
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(24)
A small library of fluoroethoxy-1,4-diphenethyl piperidine and fluoroethoxy-1,4-diphenethyl piperazine derivatives were designed, synthesized and evaluated for their ability to inhibit [3H]dopamine (DA) uptake at the vesicular monoamine transporter-2
Autor:
Linda P. Dwoskin, David S. Watt, Oleg V. Tsodikov, Justin R. Nickell, Vitaliy M. Sviripa, Eun Y. Lee, Andrii G Balia, Tianxin Yu, Wen Zhang, Chunming Liu, Florence Gizard
Publikováno v:
Journal of Medicinal Chemistry
Inhibition of the catalytic subunit of the heterodimeric methionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-dialkylaminostilbenes (FIDAS agents) offers a potential avenue for the treatment of liver and colorectal cancers where upregulat
Autor:
David B. Horton, Kiran B. Siripurapu, Justin R. Nickell, Linda P. Dwoskin, Guangrong Zheng, Peter A. Crooks
Lobeline and lobelane inhibit the behavioral and neurochemical effects of methamphetamine via an interaction with the vesicular monoamine transporter-2 (VMAT2). However, lobeline has high affinity for nicotinic receptors, and tolerance develops to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dccb9c7f2f74dc137027951a1e4cb96
https://europepmc.org/articles/PMC7050634/
https://europepmc.org/articles/PMC7050634/