Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Justin R Savage"'
Autor:
Abigail Pulsipher, Justin R Savage, Thomas P Kennedy, Kavita Gupta, Benjamin G Cuiffo, Stephen T Sonis, Won Yong Lee
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249343 (2021)
PurposeOral mucositis (OM) is a common, painful side effect of radiation therapy used for the treatment of head and neck cancer (HNC). Activation of the innate immune system upon irradiation has been identified as a key precipitating event of OM. To
Externí odkaz:
https://doaj.org/article/33b50a1c23c6495c8c45a4afa9958b76
Autor:
Jeremiah A Alt, Won Yong Lee, Brock M Davis, Justin R Savage, Thomas P Kennedy, Glenn D Prestwich, Abigail Pulsipher
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204709 (2018)
Chronic rhinosinusitis (CRS) is characterized by sustained mucosal inflammation, impaired mucociliary clearance, loss of cilia and epithelial barrier breakdown, and tissue remodeling. Certain glycosaminoglycans inhibit various inflammatory mediators,
Externí odkaz:
https://doaj.org/article/0b50e11248154b2ba1e2cfb0ab3d624c
Autor:
Justin R Savage, Abigail Pulsipher, Narayanam V Rao, Thomas P Kennedy, Glenn D Prestwich, Maria E Ryan, Won Yong Lee
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157310 (2016)
BACKGROUND:Periodontitis is characterized by microbial infection, inflammation, tissue breakdown, and accelerated loss of alveolar bone matrix. Treatment targeting these multiple stages of the disease provides ways to treat or prevent periodontitis.
Externí odkaz:
https://doaj.org/article/3d1718ec94824454ab23f2d7a82f5437
Autor:
Won Yong Lee, Justin R Savage, Jianxing Zhang, Wanjian Jia, Siam Oottamasathien, Glenn D Prestwich
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77854 (2013)
Interstitial cystitis (IC), often referred to in combination with painful bladder syndrome, is a chronic inflammatory disease of the bladder. Current therapies primarily focus on replenishing urothelial glycosaminoglycan (GAG) layer using GAG analogs
Externí odkaz:
https://doaj.org/article/c62e4a58fec641fe9d84fa62e7f21770
Autor:
Benjamin G. Cuiffo, Kavita Gupta, Stephen T. Sonis, Thomas P. Kennedy, Abigail Pulsipher, Justin R. Savage, Won Yong Lee
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249343 (2021)
PLoS ONE
PLoS ONE
Purpose Oral mucositis (OM) is a common, painful side effect of radiation therapy used for the treatment of head and neck cancer (HNC). Activation of the innate immune system upon irradiation has been identified as a key precipitating event of OM. To
Autor:
Abigail Pulsipher, Justin R. Savage, Bruce K. Rubin, Jonathan Ma, Apparao B. Kummarapurugu, Thomas P Kennedy, Judith A. Voynow, Shuo Zheng
Publikováno v:
Am J Respir Cell Mol Biol
Cystic fibrosis (CF) lung disease is marked by high concentrations of neutrophil elastase (NE) and DNA polymers; both factors contribute to airway disease. Although inhaled recombinant human dornase alfa reduces the frequency of CF pulmonary exacerba
Autor:
Abigail Pulsipher, Glenn D. Prestwich, Brock M Davis, Justin R. Savage, Jeremiah A. Alt, Thomas P. Kennedy, Won Yong Lee
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0204709 (2018)
PLoS ONE, Vol 13, Iss 9, p e0204709 (2018)
Chronic rhinosinusitis (CRS) is characterized by sustained mucosal inflammation, impaired mucociliary clearance, loss of cilia and epithelial barrier breakdown, and tissue remodeling. Certain glycosaminoglycans inhibit various inflammatory mediators,
Autor:
Patricia G. Yancey, MacRae F. Linton, Sergio Fazio, Justin R. Savage, Sean S. Davies, Venkataraman Amarnath, Zhongyi Chen, Lilu Guo, Brian J. Van Lenten
Publikováno v:
Antioxidantsredox signaling. 22(18)
Aims: Increased lipid peroxidation occurs in many conditions associated with inflammation. Because lipid peroxidation produces lipid aldehydes that can induce inflammatory responses through unknown mechanisms, elucidating these mechanisms may lead to
Autor:
Won Yong Lee, Justin R. Savage, Jianxing Zhang, Wanjian Jia, Siam Oottamasathien, Glenn D. Prestwich
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
PLoS ONE
PLoS ONE
Autor:
Li Wang, Ann Marie Hannon, Siam Oottamasathien, Lindsi McCoard Roundy, Justin R. Savage, Jianxing Zhang, Wong Yong Lee, A. Cameron Hill, Glenn D. Prestwich, Sylvia Milner, Xiangyang Ye, Wanjian Jia
Publikováno v:
The Journal of urology. 190
We established the physiological relevance of LL-37 induced bladder inflammation. We hypothesized that 1) human urinary LL-37 is increased in pediatric patients with spina bifida, 2) LL-37 induced inflammation occurs in our mouse model via urothelial