Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Justin R, Piro"'
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Autor:
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotox
Externí odkaz:
https://doaj.org/article/0481b9a2d34f41619984e7c612e1c01e
Autor:
Knut Biber, Anindya Bhattacharya, Brian M. Campbell, Justin R. Piro, Michael Rohe, Roland G.W. Staal, Robert V. Talanian, Thomas Möller
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Alzheimer’s disease (AD) is a large and increasing unmet medical need with no disease-modifying treatment currently available. Genetic evidence from genome-wide association studies (GWASs) and gene network analysis has clearly revealed a key role o
Externí odkaz:
https://doaj.org/article/0c2f30310e304652b1a16a6f8e78d74b
Autor:
Justin R. Piro, Daniel I. Benjamin, James M. Duerr, YeQing Pi, Cathleen Gonzales, Kathleen M. Wood, Joel W. Schwartz, Daniel K. Nomura, Tarek A. Samad
Publikováno v:
Cell Reports, Vol 1, Iss 6, Pp 617-623 (2012)
Although inflammation in the brain is meant as a defense mechanism against neurotoxic stimuli, increasing evidence suggests that uncontrolled, chronic, and persistent inflammation contributes to neurodegeneration. Most neurodegenerative diseases have
Externí odkaz:
https://doaj.org/article/f1b504b3e54442e2b36634e16abc72f7
Autor:
Akihiro Takano, Nahid Amini, Edmund J. Keliher, Christer Halldin, Lei Zhang, Richard E. Carson, Patrick Trapa, Sangram Nag, Ryosuke Arakawa, Deane M. Nason, Kevin P. Maresca, Zhisheng Jia, John Litchfield, Tarek A. Samad, Christopher Ryan Butler, Justin R. Piro, Timothy J. McCarthy, Deborah L. Smith, Steve O’Neil, Kari R. Fonseca
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b463c48140050426b0c96d37c2ff81
https://doi.org/10.21203/rs.3.rs-510615/v2
https://doi.org/10.21203/rs.3.rs-510615/v2
Autor:
Ryosuke, Arakawa, Akihiro, Takano, Sangram, Nag, Zhisheng, Jia, Nahid, Amini, Kevin P, Maresca, Lei, Zhang, Edmund J, Keliher, Christopher R, Butler, Justin R, Piro, Tarek A, Samad, Deborah, Smith, Deane, Nason, Steve, O'Neil, Patrick, Trapa, Kari R, Fonseca, John, Litchfield, Timothy, McCarthy, Richard E, Carson, Christer, Halldin
Publikováno v:
EJNMMI research. 12(1)
Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [Seven cynomolgus monkeys were enrolled for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a98c606e14bcd5e9f645c4b6b371c6bf
https://pubmed.ncbi.nlm.nih.gov/35244788
https://pubmed.ncbi.nlm.nih.gov/35244788
Publikováno v:
PLoS Pathogens, Vol 7, Iss 2, p e1002001 (2011)
Single-stranded polyanions ≥40 bases in length facilitate the formation of hamster scrapie prions in vitro, and polyanions co-localize with PrP(Sc) aggregates in vivo. To test the hypothesis that intact polyanionic molecules might serve as a struct
Externí odkaz:
https://doaj.org/article/a62dfa2a40da43d4ab6cb4a9073652ef
Autor:
Christopher Ryan Butler, Timothy J. McCarthy, Ryosuke Arakawa, Deborah L. Smith, Klaas Schildknegt, Justin R. Piro, Lei Zhang, Kevin P. Maresca, Laura A. McAllister, Deane M. Nason, Zhisheng Jia, Sangram Nag, Akihiro Takano, Tarek A. Samad, Christer Halldin, Anabella Villalobos, Steven Victor O'neil, Patrick Trapa
Publikováno v:
Journal of medicinal chemistry. 62(18)
Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. Preclinically, inhibition of MAGL is known to provide therapeutic benefits for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf9e513dd3ea64b1d4e6e3ab52c34c1
https://pubmed.ncbi.nlm.nih.gov/31483137
https://pubmed.ncbi.nlm.nih.gov/31483137
Autor:
Timothy L. Foley, Justin I. Montgomery, Daniel P. Uccello, Anthony R. Harris, Steven Victor O'neil, Bruce N. Rogers, Douglas S. Johnson, Justin R. Piro, Tarek A. Samad, Christopher Ryan Butler, Stephen Noell, Rafael G. Silva, Deane M. Nason, Christopher John Helal, Adam M. Gilbert, Julie Cianfrogna, Laura A. McAllister, Scot Richard Mente, Christopher L. Shaffer, Kari R. Fonseca, Damien Webb, Jayvardhan Pandit, Michael Aaron Brodney
Publikováno v:
Journal of medicinal chemistry. 61(7)
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report the discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba4448563e7b467bb25a055a46ddd6
https://pubmed.ncbi.nlm.nih.gov/29498843
https://pubmed.ncbi.nlm.nih.gov/29498843
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Autor:
Georgette L. Suidan, Thomas A. Lanz, YeQing Pi, Jie Quan, Justin R. Piro, Hualin Xi, Robert D. Bell, Tarek A. Samad, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d5abe02d0ab13fb321cf6fc3d5e11c
https://pubmed.ncbi.nlm.nih.gov/29759062
https://pubmed.ncbi.nlm.nih.gov/29759062