Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Justin Pogmore"'
Autor:
Qian Liu, Elizabeth J Osterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews
Publikováno v:
eLife, Vol 8 (2019)
Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic protein
Externí odkaz:
https://doaj.org/article/35be500a47c444d396b9241785a6b15f
Publikováno v:
Cell Death and Differentiation
Axonal degeneration and neuronal cell death are fundamental processes in development and contribute to the pathology of neurological disease in adults. Both processes are regulated by BCL-2 family proteins which orchestrate the permeabilization of th
Autor:
Lingyu Du, David W. Andrews, Fujiao Lv, Yaqing Yang, Jialing Lin, Fei Qi, James J. Chou, Alessandro Piai, Justin Pogmore, Justin Kale, Maorong Wen, Bo OuYang, Shuqing Wang, Liujuan Zhou, Bin Wu, Juan del Rosario, Zhi Zhang, Zhijun Liu
Publikováno v:
The EMBO Journal
Bax proteins form pores in the mitochondrial outer membrane to initiate apoptosis. This might involve their embedding in the cytosolic leaflet of the lipid bilayer, thus generating tension to induce a lipid pore with radially arranged lipids forming
Publikováno v:
Journal of medicinal chemistry. 64(9)
Small-molecule mediated modulation of protein interactions of Bcl-2 (B-cell lymphoma-2) family proteins was clinically validated in 2015 when Venetoclax, a selective inhibitor of the antiapoptotic protein BCL-2, achieved breakthrough status designati
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic protein
Autor:
Christian Bogner, Xiaoke Chi, Aisha Shamas-Din, Cécile Fradin, Justin Kale, Justin Pogmore, Brian Leber, David W. Andrews
Publikováno v:
Molecular Cell. 77:901-912.e9
Current models of apoptosis regulation by the Bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether Bax and Bak are activated to trigger cell death. Thus, the relative abundance and binding affini
Autor:
Christian, Bogner, Justin, Kale, Justin, Pogmore, Xiaoke, Chi, Aisha, Shamas-Din, Cécile, Fradin, Brian, Leber, David W, Andrews
Publikováno v:
Molecular cell. 77(4)
Current models of apoptosis regulation by the Bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether Bax and Bak are activated to trigger cell death. Thus, the relative abundance and binding affini
Publikováno v:
Methods in Molecular Biology ISBN: 9781493935796
The Bcl-2 family of proteins regulates the process of mitochondrial outer membrane permeabilization, causing the release of cytochrome c and committing a cell to apoptosis. The majority of the functional interactions between these proteins occur at,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe20988f66f5fdda8d19b1a8fd12c0f4
https://doi.org/10.1007/978-1-4939-3581-9_15
https://doi.org/10.1007/978-1-4939-3581-9_15
Autor:
Eve Wong, Xin Niu, Carsten Culmsee, David W. Andrews, Philipp Mergenthaler, Jing Yi, Jing Sang, Justin Pogmore, Prabhat Arya, Jialing Lin, Hetal Brahmbhatt, Brian Leber, Michael Daude, Jyoti P. Nandy, Weijia Zhu, Zhi Zhang, Fabian G. R. Ehlert, Ravi K. Jimmidi, Maragani Satyanarayana, Wibke E. Diederich
Publikováno v:
Cell Chemical Biology. 24:493-506.e5
Aberrant apoptosis can lead to acute or chronic degenerative diseases. Mitochondrial outer membrane permeabilization (MOMP) triggered by the oligomerization of the Bcl-2 family proteins Bax/ Bak is an irreversible step leading to execution of apoptos