Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Justin P Kinney"'
Autor:
Thomas Matthew Bartol, Daniel X Keller, Justin P Kinney, Chandrajit Lal Bajaj, Kristen M Harris, Terrence J Sejnowski, Mary B Kennedy
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 7 (2015)
We have built a stochastic model in the program MCell that simulates Ca2+ transients in spines from the principal molecular components believed to control Ca2+ entry and exit. Proteins, with their kinetic models, are located within two segments of de
Externí odkaz:
https://doaj.org/article/a478ccf8a7574834b680a63eb9d17882
Autor:
Justin P Kinney, Jacob G Bernstein, Andrew J Meyer, Jessica B Barber, Marti eBolivar, Bryan eNewbold, Jorg eScholvin, Caroline eMoore-Kochlacs, Christian T Wentz, Nancy J Kopell, Edward S Boyden
Publikováno v:
Frontiers in Neural Circuits, Vol 9 (2015)
Driven by the increasing channel count of neural probes, there is much effort being directed to creating increasingly scalable electrophysiology data acquisition systems. However, all such systems still rely on personal computers for data storage, an
Externí odkaz:
https://doaj.org/article/82db1922fab74dc0ba08ac23bf60da24
Autor:
Yuma Ishigami, Mandy S. Wong, Carlos Martí-Gómez, Andalus Ayaz, Mahdi Kooshkbaghi, Sonya M. Hanson, David M. McCandlish, Adrian R. Krainer, Justin B. Kinney
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce mechanistically interpretable quantitative models for the sequence-specific and co
Externí odkaz:
https://doaj.org/article/7e7874a4d36542a68979dfe3104d050b
Autor:
Ammar Tareen, Mahdi Kooshkbaghi, Anna Posfai, William T. Ireland, David M. McCandlish, Justin B. Kinney
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and massively parallel reporter assays on gene regulatory sequences. Despite their increasing popularity, a gen
Externí odkaz:
https://doaj.org/article/d828facebaf94f6cbf3c37f56bf4cdb6
Autor:
Serif Senturk, Nitin H. Shirole, Dawid G. Nowak, Vincenzo Corbo, Debjani Pal, Alexander Vaughan, David A. Tuveson, Lloyd C. Trotman, Justin B. Kinney, Raffaella Sordella
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
CRISPR/Cas9-based genome editing enables specific deletion of target genes. Here, Senturket al. develop an inducible editing system by fusing a conditional destabilization domain to Cas9 and demonstrate temporal control of gene editing in response to
Externí odkaz:
https://doaj.org/article/12bf0bf4ae954de9832a7c856f71605e
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006226 (2019)
Despite the central importance of transcriptional regulation in biology, it has proven difficult to determine the regulatory mechanisms of individual genes, let alone entire gene networks. It is particularly difficult to decipher the biophysical mech
Externí odkaz:
https://doaj.org/article/e8e83fd9d62641d9bc9b9856d5a71195
Autor:
Jonathan J Ipsaro, Chen Shen, Eri Arai, Yali Xu, Justin B Kinney, Leemor Joshua-Tor, Christopher R Vakoc, Junwei Shi
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172177 (2017)
Genetic alterations conferring resistance to the effects of chemical inhibitors are valuable tools for validating on-target effects in cells. Unfortunately, for many therapeutic targets such alleles are not available. To address this issue, we evalua
Externí odkaz:
https://doaj.org/article/26e872b66d3a4e03b22a710fa16c534c
Autor:
Chris Chronopoulos, Luís F. Seoane, Max Tegmark, Caroline Moore-Kochlacs, Edward S. Boyden, Brian D. Allen, Justin P. Kinney, Charlie Lamantia, Suhasa B. Kodandaramaiah, Jacob G. Bernstein, Jorg Scholvin
Publikováno v:
Other repository
© 2018 American Physiological Society. All rights reserved. Much innovation is currently aimed at improving the number, density, and geometry of electrodes on extracellular multielectrode arrays for in vivo recording of neural activity in the mammal
Autor:
Anthony Zorzos, Edward S. Boyden, Jacob Bernstein, Justin P. Kinney, Clifton G. Fonstad, Nancy Kopell, Caroline Moore-Kochlacs, Joerg Scholvin
Publikováno v:
Multidisciplinary Digital Publishing Institute
Micromachines
Micromachines, Vol 9, Iss 9, p 436 (2018)
Volume 9
Issue 9
Micromachines
Micromachines, Vol 9, Iss 9, p 436 (2018)
Volume 9
Issue 9
We devised a scalable, modular strategy for microfabricated 3-D neural probe synthesis. We constructed a 3-D probe out of individual 2-D components (arrays of shanks bearing close-packed electrodes) using mechanical self-locking and self-aligning tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3ca81f9fb8b57926ade207b1c5cc4a
https://orcid.org/0000-0002-8369-5308
https://orcid.org/0000-0002-8369-5308
Autor:
Caroline Moore-Kochlacs, Jorg Scholvin, Nancy Kopell, Justin P. Kinney, Clifton G. Fonstad, Jacob Bernstein, Edward S. Boyden
Publikováno v:
EMBC
We here demonstrate multi-chip heterogeneous integration of microfabricated extracellular recording electrodes with neural amplifiers, highlighting a path to scaling electrode channel counts without the need for more complex monolithic integration. W