Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Justin N. Williams"'
Autor:
Justin N Williams, Mavis Irwin, Yong Li, Anuradha Valiyakambrath, Brett T Mattingly, Sheel Patel, Mizuho Kittaka, Rebecca N Collins, Nicholas Clough, Emma H Doud, Amber L Mosley, Teresita M Bellido, Angela Bruzzaniti, Lilian I. Plotkin, Jonathan C. Trinidad, William R Thompson, Lynda F. Bonewald, Uma Sankar
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4718
Volume 24
Issue 5
Pages: 4718
Calcium/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) regulates bone remodeling through its effects on osteoblasts and osteoclasts. However, its role in osteocytes, the most abundant bone cell type, and the master regulator of bone remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb2e480e2ffef223a82db0e48bd2d0e
https://doi.org/10.3390/ijms24054718
https://doi.org/10.3390/ijms24054718
Autor:
Uma Sankar, Justin N. Williams
Publikováno v:
Current Osteoporosis Reports. 17:169-177
PURPOSE OF REVIEW: Age and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to frac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a273c017a6eae43ce6277ca3bde2c8
https://doi.org/10.1007/s11914-019-00518-w
https://doi.org/10.1007/s11914-019-00518-w
Autor:
Kathleen M Hill Gallant, Maxime A Gallant, Drew M Brown, Amy Y Sato, Justin N Williams, David B Burr
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108262 (2014)
Fracture risk in type 2 diabetes is increased despite normal or high bone mineral density, implicating poor bone quality as a risk factor. Raloxifene improves bone material and mechanical properties independent of bone mineral density. This study aim
Externí odkaz:
https://doaj.org/article/c8369321fc08471798592af0e29e4f2b
Autor:
Uma Sankar, David B. Burr, Jennifer A. Shutter, Anthony Huls, William R. Thompson, Xinchun Ding, Regis J. O'Keefe, Yong Li, Matthew R. Allen, Elsa Mével, Justin N. Williams, Brett T. Mattingly, Stephen B. Trippel, Diane R. Wagner, Anuradha Valiya Kambrath
Publikováno v:
Osteoarthritis Cartilage
Summary Objective To investigate the role of Ca2+/calmodulin-dependent protein kinase 2 (CaMKK2) in post-traumatic osteoarthritis (PTOA). Methods Destabilization of the medial meniscus (DMM) or sham surgeries were performed on 10-week-old male wild-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a1f3e481d2a954f3553c8a03c482a4
https://pubmed.ncbi.nlm.nih.gov/34506942
https://pubmed.ncbi.nlm.nih.gov/34506942
Publikováno v:
Proceedings of IMPRS. 3
Background and Hypothesis: Ca2+/calmo-dulin-dependent protein kinase kinase 2 (CaMKK2) is a serine-threonine protein kinase that plays a significant role in both anabolic and catabolic pathways of bone remodeling. Mechanical loading of bone translate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d33cc49555dd476317ef39c7f65a9f20
https://doi.org/10.18060/24525
https://doi.org/10.18060/24525
Publikováno v:
J Histochem Cytochem
Approximately 5% to 10% of all bone fractures do not heal completely, contributing to significant patient suffering and medical costs. Even in healthy individuals, fracture healing is associated with significant downtime and loss of productivity. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f90e030bcc20062d57a11e3aa4318a3
https://pubmed.ncbi.nlm.nih.gov/31928129
https://pubmed.ncbi.nlm.nih.gov/31928129
Publikováno v:
Proceedings of IMPRS. 1
Background and Hypothesis: The Ca+2/calmodulin (CaM)-mediated protein kinase kinase 2 (CaMKK2) is a multi-functional kinase with effects on cell proliferation, differentiation and metabolism. The role of CaMKK2 in bone has been explored with its abla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45859a9813967c44552f249e076b60ef
https://doi.org/10.18060/22676
https://doi.org/10.18060/22676
Publikováno v:
Journal of Visualized Experiments.
Bone fractures impose a tremendous socio-economic burden on patients, in addition to significantly affecting their quality of life. Therapeutic strategies that promote efficient bone healing are non-existent and in high demand. Effective and reproduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df5a83da270b8da7cd63df5cc726394
https://doi.org/10.3791/58122
https://doi.org/10.3791/58122
Autor:
Austin J. Pucylowski, Stuart J. Warden, Melissa A. Kacena, Roshni B. Patel, Kyung Shin Kang, David B. Burr, Matthew R. Allen, Justin N. Williams, Michael J. Voor, Mariah A. Hassert, Alexander G. Robling, William R. Thompson, Uma Sankar, Elsa Mevel, Yong Li, Anuradha Valiya Kambrath, Ying Hua Cheng
Approximately 10% of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient bone healing. Inhibition of Ca2+ /calmodulin (CaM)-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fe0a3e2486884d701823c92197917a
https://europepmc.org/articles/PMC6549722/
https://europepmc.org/articles/PMC6549722/
Autor:
Theresa A. Guise, Uma Sankar, Justin N. Williams, Austin J. Pucylowski, Eric S. Chang, Khalid S. Mohammad, Ushashi C. Dadwal
Publikováno v:
Cancer Research. 78:3987-3987
Prostate cancer (PCa), the most frequently diagnosed cancer in men, will have an estimated 26,730 deaths in the US during 2017. Predominantly, these deaths will be caused due to metastatic disease. PCa preferentially metastasizes to the bone undermin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee814e4031b29cf4392879bb502ad30b
https://doi.org/10.1158/1538-7445.am2018-3987
https://doi.org/10.1158/1538-7445.am2018-3987