Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Justin Michael Drerup"'
Autor:
Yilun Deng, Justin Michael Drerup, Xinyue Zhang, Ryan M Reyes, Jenny Mendez, Miro E Raeber, Myrna G Garcia, Alvaro S Pardon, Harshita B. Gupta, Onur Boyman, Tyler J Curiel
Publikováno v:
The Journal of Immunology. 206:57.17-57.17
Regulatory T cells (Treg) engage IL-2 by high affinity CD25, and anti-tumor effector T cells (Teff) use intermediate affinity CD122. We studied IL-2 complexes (IL-2c) that selectively activate CD122+ Teff over CD25+ Tregs. We found IL-2c but not aPD-
Autor:
Yilun Deng, Harshita B. Gupta, Justin Michael Drerup, Ryan Michael Reyes, Jenny Mendez, Xinyue Zhang, Alvaro S Padron, Myrna Garcia, Tyler J Curiel
Publikováno v:
The Journal of Immunology. 202:136.15-136.15
Anti-tumor T cells (Teffs) engage IL2 largely through CD122, vs. CD25 for regulatory T cells (Tregs). In ID8agg ovarian cancer (OC), CD122-selective IL2 complexes (IL2c, made from CD122-blocking ab+IL-2), increased Teff numbers and functions as expec
Autor:
Harshita B. Gupta, Shunhua Lao, Alvaro Padron, Mei Zhou, Jinyou Liu, Curtis A. Clark, Justin Michael Drerup, Myrna Garcia, Gangadhara Sareddy, Vincent Hurez, Rong Li, Ratna Vadlamudi, Tyler J. Curiel
Publikováno v:
The Journal of Immunology. 200:178.41-178.41
We reported that PD-L1 regulates tumor cell-intrinsic mTOR, autophagy and tumor initiating cell (TIC) generation. We found significant cytoplasmic PD-L1 in various mouse and human tumor cell lines by Western, flow cytometry and confocal. To assess su
Autor:
Harshita B. Gupta, June Deng, Curtis A. Clark, Justin Michael Drerup, Bogang Wu, Gangadhara Sareddy, Vincent Hurez, Ratna Vadlamudi, Rong Li, Tyler J. Curiel
Publikováno v:
The Journal of Immunology. 200:167.15-167.15
TIC mediate tumor formation, drug resistance and relapse. We reported that PD-L1 promotes tumor mTORC1, and TIC number and functions. Knocking down PD-L1 reduced expression of stemness genes Oct4 and Nanog and the mTORC1 signaling component Raptor in
Publikováno v:
The Journal of Immunology. 196:211.19-211.19
Age is the greatest cancer risk factor, but contributions of aging to tumor intrinsic properties and immunotherapy responses are poorly understood as most preclinical studies are in young hosts. We assessed age effects on tumor properties, progressio
Autor:
Justin Michael Drerup, Alvaro Souto Padron, Wanjiao Chen, Curtis Anthony Clark, Tyler Jay Curiel
Publikováno v:
The Journal of Immunology. 196:212.22-212.22
We used a defined IL-2/αIL-2 complex that directs IL-2 to stimulate only intermediate-affinity IL-2 receptor (CD122/132) to promote tumor rejection and avoid regulatory T cell (Treg) expansion. However, it is unknown if IL-2/αIL-2 alters Treg funct