Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Autor: Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-depende

Externí odkaz: https://doaj.org/article/784327815c984356aac217a9fbd2ed1e

Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial

Autor: Melissa L. Abel, Nobuyuki Takahashi, Cody Peer, Christophe E. Redon, Samantha Nichols, Rasa Vilimas, Min-Jung Lee, Sunmin Lee, Meenakshi Shelat, Robbie Kattappuram, Linda Sciuto, Danielle Pinkiert, Chante Graham, Donna Butcher, Baktiar Karim, Ajit Kumar Sharma, Justin Malin, Rajesh Kumar, Christopher W. Schultz, Shubhank Goyal, Jaydira del Rivero, Manan Krishnamurthy, Deep Upadhyay, Brett Schroeder, Tristan Sissung, Manoj Tyagi, Jung Kim, Yves Pommier, Mirit Aladjem, Mark Raffeld, William Douglas Figg, Jane Trepel, Liqiang Xi, Parth Desai, Anish Thomas

Publikováno v: Clinical Cancer Research. :OF1-OF9

Purpose: Despite promising preclinical studies, toxicities have precluded combinations of chemotherapy and DNA damage response (DDR) inhibitors. We hypothesized that tumor-targeted chemotherapy delivery might enable clinical translation of such combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7569233e3f1b0b4fb6c6e06fd96f0032
https://doi.org/10.1158/1078-0432.ccr-23-0536

Supplementary Figure S2 from Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial

Autor: Anish Thomas, Parth Desai, Liqiang Xi, Jane Trepel, William Douglas Figg, Mark Raffeld, Mirit Aladjem, Yves Pommier, Jung Kim, Manoj Tyagi, Tristan Sissung, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Jaydira del Rivero, Shubhank Goyal, Christopher W. Schultz, Rajesh Kumar, Justin Malin, Ajit Kumar Sharma, Baktiar Karim, Donna Butcher, Chante Graham, Danielle Pinkiert, Linda Sciuto, Robbie Kattappuram, Meenakshi Shelat, Sunmin Lee, Min-Jung Lee, Rasa Vilimas, Samantha Nichols, Christophe E. Redon, Cody Peer, Nobuyuki Takahashi, Melissa L. Abel

Pharmacokinetic assessment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06619753b143d9112a4bb0c3cb9b8e1
https://doi.org/10.1158/1078-0432.23183851.v1

Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol

Autor: Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas A. Spidale, Jennifer Cowan, Susannah C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi

Publikováno v: Immunity. 56:562-575.e6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::327d61a741c452aecfba288c575f48aa
https://doi.org/10.1016/j.immuni.2023.01.025

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Autor: Jonathan W. Yewdell, Justin Malin, Izumi Ohigashi, Avinash Bhandoola, Yousuke Takahama, Yongge Zhao, Christelle Harly, Maggie Cam, Mina O. Seedhom, Michael C. Kelly, Jennifer E. Cowan

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5498. ⟨10.1038/s41467-019-13465-y⟩

Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2432618c883406a69f5ee20cc91d45
http://repo.lib.tokushima-u.ac.jp/115228