Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Justin M. Wolfe"'
Autor:
Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
Publikováno v:
ACS Central Science, Vol 4, Iss 4, Pp 512-520 (2018)
Externí odkaz:
https://doaj.org/article/ba59032996b34292a5f0d8f8ca12c36f
Autor:
Choi-Fong Cho, Justin M. Wolfe, Colin M. Fadzen, David Calligaris, Kalvis Hornburg, E. Antonio Chiocca, Nathalie Y. R. Agar, Bradley L. Pentelute, Sean E. Lawler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform
Externí odkaz:
https://doaj.org/article/66ff86f13d85438c93395cad172f6fbe
Autor:
Anthony J. Rojas, Justin M. Wolfe, Heemal H. Dhanjee, Ivan Buslov, Nicholas L. Truex, Richard Y. Liu, Walter Massefski, Bradley L. Pentelute, Stephen L. Buchwald
Publikováno v:
Chemical Science. 13:11891-11895
The synthesis of palladium oxidative addition complexes derived from unprotected peptides is described. Incorporation of 4-halophenylalanine into a peptide during solid phase peptide synthesis allows for subsequent oxidative addition at this position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a095bf2b19f1533c2ddefc1f0abae04
https://doi.org/10.1039/d2sc04074c
https://doi.org/10.1039/d2sc04074c
Autor:
Justin M. Wolfe, Alexander J. Mijalis, Chi Zhang, Andrei Loas, Kyle A. Totaro, Bradley L. Pentelute, Mark D. Simon, Jessica Laura Wilson, Alexander A. Vinogradov, Daniel L. Dunkelmann, Yuta Maki
Publikováno v:
Total Chemical Synthesis of Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb697cfc02c9d469a73fc6a13a46250
https://doi.org/10.1002/9783527823567.ch2
https://doi.org/10.1002/9783527823567.ch2
Autor:
Rebecca L. Holden, Monica Yao, Bradley L. Pentelute, Zi-Ning Choo, Gunnar J. Hanson, Carly K. Schissel, Colin M. Fadzen, Justin M. Wolfe
Publikováno v:
Biochemistry. 58:3980-3989
Phosphorodiamidate morpholino oligonucleotides (PMOs) make up a promising class of therapeutics for genetic disease. PMOs designed for "exon skipping" must be internalized into cells, reach the nucleus, and act on pre-mRNA to mediate their effects. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a74cd4d381ea76bdd995d5a122b2cd
https://doi.org/10.1021/acs.biochem.9b00413
https://doi.org/10.1021/acs.biochem.9b00413
Autor:
Rebecca L. Holden, Monica Yao, Zi-Ning Choo, Bradley L. Pentelute, Gunnar J. Hanson, Justin M. Wolfe, Colin M. Fadzen
Publikováno v:
ACS Central Science
ACS Central Science, Vol 4, Iss 4, Pp 512-520 (2018)
ACS Central Science, Vol 4, Iss 4, Pp 512-520 (2018)
Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules, including proteins and oligonucleotides. Although hundreds of CPP sequences are described in the literature, predicting efficaciou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74b94e1ab51a1b2c88754d05bd7ff65
http://europepmc.org/articles/PMC5920612
http://europepmc.org/articles/PMC5920612
Autor:
Colin M. Fadzen, Justin M. Wolfe, Bradley L. Pentelute, Gunnar J. Hanson, Monica Yao, Rebecca L. Holden
Publikováno v:
PMC
Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires that these macromolecules reach the nucleus. While cell-penetrating peptides can improve delivery, proteolytic instability oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a3d511341fef6f19cc031fc578e542
https://doi.org/10.1002/ange.201801167
https://doi.org/10.1002/ange.201801167
Autor:
Colin M. Fadzen, E. Antonio Chiocca, Justin M. Wolfe, Sean E. Lawler, Bradley L. Pentelute, Choi-Fong Cho
Publikováno v:
Journal of the American Chemical Society. 139:15628-15631
Here we describe the utility of peptide macrocyclization through perfluoroaryl-cysteine SNAr chemistry to improve the ability of peptides to cross the blood–brain barrier. Multiple macrocyclic analogues of the peptide transportan-10 were investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757b7bf69f0c97b5f0114ea39aa59109
https://doi.org/10.1021/jacs.7b09790
https://doi.org/10.1021/jacs.7b09790
Autor:
Choi-Fong Cho, Justin M. Wolfe, Nina Hartrampf, Ennio Antonio Chiocca, Sean E. Lawler, Yuan Qu, Sonja Bergmann, Fernanda Bononi, Emily Murrell, Niklas von Spreckelsen, Yarah Ghotmi, Colin M. Fadzen, Bradley L. Pentelute, Leonard G. Luyt, Martine L.M. Lamfers, Keith L. Ligon, Mariano S. Viapiano
Publikováno v:
Neuro Oncol
High-grade gliomas are deadly cancers, and current standard-of-care has demonstrated limited success. The ability to specifically target glioma cells allows for the development of safer and more efficacious brain cancer therapy strategies. Brevican,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a31a499b0e9e3892336273be89dbf4
https://europepmc.org/articles/PMC6847537/
https://europepmc.org/articles/PMC6847537/
Autor:
Benjamin Scott, Sonja Bergmann, Marie Foley Kijewski, Charlotte E. Farquhar, Keith L. Ligon, Choi-Fong Cho, Mykola Zdioruk, Shuyan Wang, Sean E. Lawler, Mariano S. Viapiano, Leonard G. Luyt, Colin M. Fadzen, Bo Yeun Yang, Shipra Dubey, Martine L.M. Lamfers, Nina Hartrampf, E. Antonio Chiocca, Fernanda Bononi, Justin M. Wolfe, Marcelo F. DiCarli, Yarah Ghotmi, Bradley L. Pentelute, Niklas von Spreckelsen, J Roscoe Wasserburg, Emily Murrell
Publikováno v:
Adv Ther (Weinh)
Advanced Therapeutics, 4(4):2000244. Wiley-Blackwell Publishing Ltd
Advanced Therapeutics, 4(4):2000244. Wiley-Blackwell Publishing Ltd
Glioblastoma (GBM) is the most common and deadliest form of brain tumor and remains amongst the most difficult cancers to treat. Brevican (Bcan), a central nervous system (CNS)-specific extracellular matrix protein, is upregulated in high-grade gliom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1564f0424892ab1685b41b3a490d5fc
https://doi.org/10.1002/adtp.202000244
https://doi.org/10.1002/adtp.202000244