Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Justin M. Richner"'
Autor:
Vinothini Arunagiri, Laura Cooper, Huali Dong, Jake Class, Indrani Biswas, Sujan Vahora, Riddhi Deshpande, Khushi H. Gopani, Guochang Hu, Justin M. Richner, Lijun Rong, Jing Liu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been demonstrated to limit the host interferon response; however, the underlying mechanism remains unclear. Here, we found that SARS-CoV-2 infection upregulated the E3 ubiquitin ligase
Externí odkaz:
https://doaj.org/article/1c877b442ba24ad0a7df4f6d1c8abd34
Autor:
Tanushree Dangi, Sarah Sanchez, Min Han Lew, Bakare Awakoaiye, Lavanya Visvabharathy, Justin M. Richner, Igor J. Koralnik, Pablo Penaloza-MacMaster
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112167- (2023)
Summary: mRNA vaccines are effective in preventing severe COVID-19, but breakthrough infections, emerging variants, and waning immunity warrant the use of boosters. Although mRNA boosters are being implemented, the extent to which pre-existing immuni
Externí odkaz:
https://doaj.org/article/7c8ddd98073c4f82ba7249389c71d584
Autor:
Tanushree Dangi, Sarah Sanchez, Jacob Class, Michelle Richner, Lavanya Visvabharathy, Young Rock Chung, Kirsten Bentley, Richard J. Stanton, Igor J. Koralnik, Justin M. Richner, Pablo Penaloza-MacMaster
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main antigen in all approved COVID-19 vaccines and is also the only target for monoclonal antibody (mAb) therapies. Immune responses to other viral antigens are gen
Externí odkaz:
https://doaj.org/article/c6f05bf9be5d495988ce89845a418e01
Autor:
Clayton J. Wollner, Justin M. Richner
Publikováno v:
Vaccines, Vol 9, Iss 2, p 148 (2021)
Numerous vaccines have now been developed using the mRNA platform. In this approach, mRNA coding for a viral antigen is in vitro synthesized and injected into the host leading to exogenous protein expression and robust immune responses. Vaccines can
Externí odkaz:
https://doaj.org/article/fddea87b6cc84e7f8e0a00bad7257c45
Autor:
Jonathan J. Miner, Abdoulaye Sene, Justin M. Richner, Amber M. Smith, Andrea Santeford, Norimitsu Ban, James Weger-Lucarelli, Francesca Manzella, Claudia Rückert, Jennifer Govero, Kevin K. Noguchi, Gregory D. Ebel, Michael S. Diamond, Rajendra S. Apte
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3208-3218 (2016)
Zika virus (ZIKV) is an emerging flavivirus that causes congenital abnormalities and Guillain-Barré syndrome. ZIKV infection also results in severe eye disease characterized by optic neuritis, chorioretinal atrophy, and blindness in newborns and con
Externí odkaz:
https://doaj.org/article/766a998ca629426fbdb33df443eb65d9
Autor:
Mariah Hassert, Elizabeth Geerling, E Taylor Stone, Tara L Steffen, Madi S Feldman, Alexandria L Dickson, Jacob Class, Justin M Richner, James D Brien, Amelia K Pinto
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009163 (2020)
The novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic. Critical to the rapid evaluation of vaccines and antivirals against SARS-CoV-2 is the development of tractable animal models to understan
Externí odkaz:
https://doaj.org/article/212c6c34799047e391f6a891d7067982
Publikováno v:
bioRxiv
Advanced age is a significant risk factor during viral infection due to an age-associated decline in the immune response. Older individuals are especially susceptible to severe neuroinvasive disease after West Nile virus (WNV) infection. Previous stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371089b85d69315b22cf2bd1be3f333c
https://europepmc.org/articles/PMC9881888/
https://europepmc.org/articles/PMC9881888/
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a major cause of morbidity and mortality, often as a result of acute respiratory distress syndrome. Respi
Objective: SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a major cause of morbidity and mortality, often as a result of acute respiratory distress syndrome. Respi
Autor:
Zeenat Farooq, Fedho Kusuma, Phillip Burke, Catherine R. Dufour, Duckgue Lee, Negar Tabatabaei, Phoenix Toboz, Ernest Radovani, Jack F. Greenblatt, Jalees Rehman, Jacob Class, Arkady Khoutorsky, Bruno D. Fonseca, Justin M. Richner, Eloi Mercier, Guillaume Bourque, Vincent Giguère, Arvind R. Subramaniam, Jaeseok Han, Soroush Tahmasebi
Publikováno v:
The Journal of biological chemistry. 298(9)
La-related protein 1 (LARP1) has been identified as a key translational inhibitor of terminal oligopyrimidine (TOP) mRNAs downstream of the nutrient sensing protein kinase complex, mTORC1. LARP1 exerts this inhibitory effect on TOP mRNA translation b
Autor:
Tanushree Dangi, Sarah Sanchez, Mincheol Park, Jacob Class, Michelle Richner, Justin M. Richner, Pablo Penaloza-MacMaster
SummaryThe spike protein of SARS-CoV-2 is a critical antigen present in all approved SARS-CoV-2 vaccines. This surface viral protein is also the target for all monoclonal antibody therapies, but it is unclear whether antibodies targeting other viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4990dd8536296a1546d5ef8b23e42f9
https://doi.org/10.1101/2022.03.09.483635
https://doi.org/10.1101/2022.03.09.483635