Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Justin M. Mitchell"'
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39815 (2012)
F-actin remodelling is essential for a wide variety of cell processes. It is important in exocytosis, where F-actin coats fusing exocytic granules. The purpose of these F-actin coats is unknown. They may be important in stabilizing the fused granules
Externí odkaz:
https://doaj.org/article/2f309f76c06246c5a4e6ffc21e7971bd
Autor:
Paula M. Loria, Aline Dantas de Araujo, David Price, Adam J. Cotterell, David A. Griffith, Spiros Liras, Timothy A. Hill, David P. Fairlie, Weijun Xu, David R. Derksen, Robert V. Stanton, Fabien Plisson, Huy N. Hoang, Justin M. Mitchell, David J. Edmonds
Publikováno v:
European Journal of Medicinal Chemistry. 127:703-714
Glucagon-like peptide (GLP-1) is an endogenous hormone that induces insulin secretion from pancreatic islets and modified forms are used to treat diabetes mellitus type 2. Understanding how GLP-1 interacts with its receptor (GLP-1R) can potentially l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1066e3cc401d5d060001151234d3a5
https://doi.org/10.1016/j.ejmech.2016.10.044
https://doi.org/10.1016/j.ejmech.2016.10.044
Autor:
Justin M. Mitchell, Joakim E. Swedberg, Spiros Liras, Roger B. Ruggeri, David A. Griffith, David J. Edmonds, David P. Fairlie, Paula M. Loria, David Price, David J. Craik, Christina I. Schroeder, Thomas Durek, David R. Derksen
Publikováno v:
European Journal of Medicinal Chemistry. 103:175-184
Type 2 diabetes mellitus (T2DM) results from compromised pancreatic β-cell function, reduced insulin production, and lowered insulin sensitivity in target organs resulting in hyperglycemia. The GLP-1 hormone has two biologically active forms, GLP-1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4964b67c73c2dc5e67f36a69c5039c1c
https://doi.org/10.1016/j.ejmech.2015.08.046
https://doi.org/10.1016/j.ejmech.2015.08.046
Autor:
Spiros Liras, David W. Piotrowski, David R. Derksen, W. Mei Kok, Timothy A. Hill, David Price, Kun Song, David P. Fairlie, Jacky Y. Suen, Paula M. Loria, David A. Griffith, Jane M. Withka, Alan M. Mathiowetz, David J. Edmonds, Vincent Mascitti, Huy N. Hoang, Chris Limberakis, Justin M. Mitchell, Robert V. Stanton
Publikováno v:
Journal of Medicinal Chemistry. 58:4080-4085
Cyclic constraints are incorporated into an 11-residue analogue of the N-terminus of glucagon-like peptide-1 (GLP-1) to investigate effects of structure on agonist activity. Cyclization through linking side chains of residues 2 and 5 or 5 and 9 produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5463a16c556b351f45c0945b48f8486
https://doi.org/10.1021/acs.jmedchem.5b00166
https://doi.org/10.1021/acs.jmedchem.5b00166
Autor:
Peter Thorn, Oanh H. Do, Jiun T. Low, Wan Jun Gan, Michael Zavortink, Herbert Y. Gaisano, Justin M. Mitchell, Christof J. Schwiening
Publikováno v:
Diabetologia
Aims/hypothesis We set out to test the hypothesis that insulin secretion from beta cells is targeted towards the vasculature. Methods The spatial location of granule fusion was identified by live-cell two-photon imaging of mouse pancreatic beta cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0be44a4f2d498fa438901d60c509400
https://doi.org/10.1007/s00125-014-3252-6
https://doi.org/10.1007/s00125-014-3252-6
Autor:
Michael Zavortink, Jiun T. Low, Garry Morgan, Oanh H. Do, Robert G. Parton, Alicia Rawlings, Justin M. Mitchell, Herbert Y. Gaisano, Jacinda Bax, Peter Thorn
Publikováno v:
Diabetologia. 56:2629-2637
In dispersed single beta cells the response of each cell to glucose is heterogeneous. In contrast, within an islet, cell-to-cell communication leads to glucose inducing a more homogeneous response. For example, increases in NAD(P)H and calcium are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d73c097468a1c80f9429763a1a43061
https://doi.org/10.1007/s00125-013-3019-5
https://doi.org/10.1007/s00125-013-3019-5
Autor:
David A. Griffith, David J. Edmonds, Spiros Liras, Roger B. Ruggeri, Christina I. Schroeder, Justin M. Mitchell, Joakim E. Swedberg, David J. Craik, David R. Derksen, David P. Fairlie, David Price, Paula M. Loria
Glucagon-like peptide-1 (GLP-1) signaling through the glucagon-like peptide 1 receptor (GLP-1R) is a key regulator of normal glucose metabolism, and exogenous GLP-1R agonist therapy is a promising avenue for the treatment of type 2 diabetes mellitus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acf427e2f74896177155e5036165ddd
https://europepmc.org/articles/PMC4957059/
https://europepmc.org/articles/PMC4957059/
Real-time measurement of F-actin remodelling during exocytosis using Lifeact-EGFP transgenic animals
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e39815 (2012)
PLoS ONE, Vol 7, Iss 7, p e39815 (2012)
F-actin remodelling is essential for a wide variety of cell processes. It is important in exocytosis, where F-actin coats fusing exocytic granules. The purpose of these F-actin coats is unknown. They may be important in stabilizing the fused granules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5f7b003bd1e42ec6cd2a57726030bd
https://pubmed.ncbi.nlm.nih.gov/22768313
https://pubmed.ncbi.nlm.nih.gov/22768313
Autor:
Huy N. Hoang, Kun Song, TimothyA. Hill, David R. Derksen, David J. Edmonds, W. Mei Kok, Chris Limberakis, Spiros Liras, Paula M. Loria, Vincent Mascitti, Alan M. Mathiowetz, Justin M. Mitchell, DavidW. Piotrowski, David A. Price, Robert V. Stanton, Jacky Y. Suen, JaneM. Withka, David A. Griffith, David P. Fairlie
Publikováno v:
Journal of Medicinal Chemistry; May2015, Vol. 58 Issue 9, p4080-4085, 6p