Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Justin M. Di Trani"'
Autor:
Ana Paula Lobez, Fei Wu, Justin M. Di Trani, John L. Rubinstein, Mikael Oliveberg, Peter Brzezinski, Agnes Moe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Recent studies have established that cellular electrostatic interactions are more influential than assumed previously. Here, we use cryo-EM and perform steady-state kinetic studies to investigate electrostatic interactions between cytochrome
Externí odkaz:
https://doaj.org/article/738fcf75ed4f40e2b9d85af5aa5ca206
Autor:
Justin M. Di Trani, Stephane De Cesco, Rebecca O’Leary, Jessica Plescia, Claudia Jorge do Nascimento, Nicolas Moitessier, Anthony K. Mittermaier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
There is growing evidence that the kinetics of interactions between inhibitors and their targets can strongly impact therapeutic efficacy. Here the authors describe an isothermal titration calorimetry-based method that can rapidly quantify inhibition
Externí odkaz:
https://doaj.org/article/695ef23f7e8d4d87a44cc9ad450d7ebc
Autor:
David J Yanofsky, Justin M Di Trani, Sylwia Król, Rana Abdelaziz, Stephanie A Bueler, Peter Imming, Peter Brzezinski, John L Rubinstein
Publikováno v:
eLife, Vol 10 (2021)
The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis activity in humans. Telacebec inhibits the mycobacterial respiratory supercomplex composed of co
Externí odkaz:
https://doaj.org/article/1d6aa07f32734bd39aa34dc44cea219b
Autor:
Rana Abdelaziz, Justin M Di Trani, Henok Sahile, Lea Mann, Adrian Richter, Zhongle Liu, Stephanie A. Bueler, Leah E. Cowen, John L. Rubinstein, Peter Imming
Publikováno v:
ACS Omega.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5c13821879697fa7bd3ac939a389bf1
https://doi.org/10.1021/acsomega.3c02259
https://doi.org/10.1021/acsomega.3c02259
Flexible client-dependent cages in the assembly landscape of the periplasmic protease-chaperone DegP
The periplasmic protein DegP, that is implicated in virulence factor transport leading to pathogenicity, is a bi-functional protease and chaperone that maintains protein homeostasis in gram-negative bacteria. To perform these functions, DegP captures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd36d32446f3fd55d3e1d68f7c027b7b
https://doi.org/10.1101/2022.10.17.512556
https://doi.org/10.1101/2022.10.17.512556
Autor:
Sylwia Król, Rana Abdelaziz, John L. Rubinstein, Stephanie A. Bueler, Peter Brzezinski, David J. Yanofsky, Justin M. Di Trani, Peter Imming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bdd4553845187e47ed01caa66326b35
https://doi.org/10.7554/elife.71959.sa2
https://doi.org/10.7554/elife.71959.sa2
Autor:
Peter Brzezinski, Sylwia Król, John L. Rubinstein, David J. Yanofsky, Peter Imming, Justin M. Di Trani, Rana Abdelaziz, Stephanie A. Bueler
Publikováno v:
eLife, Vol 10 (2021)
The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis activity in humans. Telacebec inhibits the mycobacterial respiratory supercomplex composed of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a9911d46cbc91b371a82d4e0a66948
https://elifesciences.org/articles/71959
https://elifesciences.org/articles/71959
Autor:
Sylwia Król, Peter Brzezinski, David J. Yanofsky, Justin M. Di Trani, Stephanie A. Bueler, John L. Rubinstein, Peter Imming, Rana Abdelaziz
The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than fifty years with demonstrated antituberculosis activity in humans. Telacebec inhibits the mycobacterial respiratory supercomplex composed of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a8f7cdbb8b552de718889c58801210
https://doi.org/10.1101/2021.07.06.451285
https://doi.org/10.1101/2021.07.06.451285
Autor:
Ali Haydaroglu, Christopher M. Yip, Hui Guo, Timothy Kwok, Samir Benlekbir, Aaron Au, Zev A Ripstein, Justin M. Di Trani, John L. Rubinstein
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
A method is presented for high-speed low-volume cryo-EM specimen preparation with a device constructed from readily available components.
Although microscopes and image-analysis software for electron cryomicroscopy (cryo-EM) have improved dramat
Although microscopes and image-analysis software for electron cryomicroscopy (cryo-EM) have improved dramat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9437c7c8078ac44583d40933a98aa0d
https://doi.org/10.1107/s2059798319014372
https://doi.org/10.1107/s2059798319014372
Autor:
Leah E. Cowen, John L. Rubinstein, Justin M. Di Trani, Peter Brzezinski, Zhongle Liu, Luke Whitesell
Publikováno v:
Structure (London, England : 1993). 30(1)
Electron transfer between respiratory complexes drives transmembrane proton translocation, which powers ATP synthesis and membrane transport. The homodimeric respiratory complex III (CIII2) oxidizes ubiquinol to ubiquinone, transferring electrons to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6a148e2d85b2d4ba28293893f6953d
https://pubmed.ncbi.nlm.nih.gov/34525326
https://pubmed.ncbi.nlm.nih.gov/34525326