Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Justin M O'Sullivan"'
Autor:
Michele Zuppi, Tommi Vatanen, Brooke C. Wilson, Evgeniia Golovina, Theo Portlock, Wayne S. Cutfield, Mark H. Vickers, Justin M. O’Sullivan
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Background Fecal microbiota transplantation (FMT) is a therapeutic intervention used to treat diseases associated with the gut microbiome. In the human gut microbiome, phages have been implicated in influencing human health, with successful
Externí odkaz:
https://doaj.org/article/5c382e0f7acd4b4bb772118bcc5e4ee2
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Machine learning (ML) has shown great promise in genetics and genomics where large and complex datasets have the potential to provide insight into many aspects of disease risk, pathogenesis of genetic disorders, and prediction of health and wellbeing
Externí odkaz:
https://doaj.org/article/b7bb2478e14143a9b47f5037b09a34a1
Autor:
Ry Yves Tweedie-Cullen, Brooke C. Wilson, José G. B. Derraik, Benjamin B. Albert, Keri Opai, Taygen Edwards, Justin M. O’Sullivan, Wayne S. Cutfield
Publikováno v:
Frontiers in Gastroenterology, Vol 3 (2024)
IntroductionGut microbiome transfer (GMT or faecal microbiome transfer) is gaining increasing attention as a potential treatment for a range of medical conditions. However, public awareness and acceptance are not well understood.MethodsTo better unde
Externí odkaz:
https://doaj.org/article/34dbe3644dce4b13b792c79cfb0fbf9d
Autor:
Michael Pudjihartono, Evgeniia Golovina, Tayaza Fadason, Justin M. O'Sullivan, William Schierding
Publikováno v:
Molecular Oncology, Vol 18, Iss 4, Pp 1031-1048 (2024)
Genome‐wide association studies (GWAS) have associated 76 loci with the risk of developing melanoma. However, understanding the molecular basis of such associations has remained a challenge because most of these loci are in non‐coding regions of
Externí odkaz:
https://doaj.org/article/cbc11b2d72d64248b311024e1ffd34e5
Autor:
Sophie L. Farrow, Sreemol Gokuladhas, William Schierding, Michael Pudjihartono, Jo K. Perry, Antony A. Cooper, Justin M. O’Sullivan
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Genome wide association studies (GWAS) have identified a number of genomic loci that are associated with Parkinson’s disease (PD) risk. However, the majority of these variants lie in non-coding regions, and thus the mechanisms by which the
Externí odkaz:
https://doaj.org/article/777c62e53bcb4a74b6e99d11f4201189
Autor:
Anna H. Behling, Brooke C. Wilson, Daniel Ho, Wayne S. Cutfield, Tommi Vatanen, Justin M. O’Sullivan
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Horizontal gene transfer (HGT) describes the transmission of DNA outside of direct ancestral lineages. The process is best characterised within the bacterial kingdom and can enable the acquisition of genetic traits that support ba
Externí odkaz:
https://doaj.org/article/6fa17500bdfe4bc4b0627c8f7afcef61
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Understanding the biological mechanisms that underlie the non-motor symptoms of Parkinson’s disease (PD) requires comprehensive frameworks that unravel the complex interplay of genetic risk factors. Here, we used a disease-agnostic brain c
Externí odkaz:
https://doaj.org/article/6dd402107b234c59b28d7d0ed83993f1
Autor:
Farha Ramzan, Jing Rong, Claire T. Roberts, Justin M. O’Sullivan, Jo K. Perry, Rennae Taylor, Lesley McCowan, Mark H. Vickers
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9536 (2024)
Globally, preterm birth (PTB) is a primary cause of mortality and morbidity in infants, with PTB rates increasing worldwide over the last two decades. Biomarkers for accurate early prediction of PTB before the clinical event do not currently exist. G
Externí odkaz:
https://doaj.org/article/6a98b90299c947ffa5190524579095d5
Autor:
José G B Derraik, Wayne S Cutfield, Benjamin B Albert, Tommi Vatanen, Justin M O'Sullivan, Hiran Thabrew, Brooke C Wilson, Ry Y Tweedie-Cullen, Christine Creagh, Marysia Depczynski, Taygen Edwards, Karen Leong, Ruth Monk, Kathryn Beck
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Autism (formally autism spectrum disorder) encompasses a group of complex neurodevelopmental conditions, characterised by differences in communication and social interactions. Co-occurring chronic gastrointestinal symptoms are common amo
Externí odkaz:
https://doaj.org/article/8af510e94e604d3aa6a2fccd62078435
Autor:
Rachel K. Jaros, Tayaza Fadason, David Cameron-Smith, Evgeniia Golovina, Justin M. O’Sullivan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection outcomes and comorbidities interact to impact acute and long-term sequelae is essential if we are to reduce the ongoing health burdens of the COVID-19 pandemic.
Externí odkaz:
https://doaj.org/article/85b26c579ca742c5afe0bf14eb9a2def