Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Justin M Kollman"'
Autor:
William R Hardin, Germain C M Alas, Nikita Taparia, Elizabeth B Thomas, Melissa C Steele-Ogus, Kelli L Hvorecny, Aaron R Halpern, Pavla Tůmová, Justin M Kollman, Joshua C Vaughan, Nathan J Sniadecki, Alexander R Paredez
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010496 (2022)
Attachment to the intestinal epithelium is critical to the lifestyle of the ubiquitous parasite Giardia lamblia. The ventrolateral flange is a sheet-like membrane protrusion at the interface between parasites and attached surfaces. This structure has
Externí odkaz:
https://doaj.org/article/1702a80e08fd48c2aac1b51efbb80ac2
Autor:
Jesse M Hansen, Avital Horowitz, Eric M Lynch, Daniel P Farrell, Joel Quispe, Frank DiMaio, Justin M Kollman
Publikováno v:
eLife, Vol 10 (2021)
Many metabolic enzymes self-assemble into micron-scale filaments to organize and regulate metabolism. The appearance of these assemblies often coincides with large metabolic changes as in development, cancer, and stress. Yeast undergo cytoplasmic aci
Externí odkaz:
https://doaj.org/article/e958299121e7450aac97494ed011adbf
Autor:
Matthew C Johnson, Justin M Kollman
Publikováno v:
eLife, Vol 9 (2020)
Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in respons
Externí odkaz:
https://doaj.org/article/9618ee5fe1d04f69960028414b45bffb
Autor:
Cassandra Kamischke, Junping Fan, Julien Bergeron, Hemantha D Kulasekara, Zachary D Dalebroux, Anika Burrell, Justin M Kollman, Samuel I Miller
Publikováno v:
eLife, Vol 8 (2019)
The outer membrane (OM) of Gram-negative bacteria serves as a selective permeability barrier that allows entry of essential nutrients while excluding toxic compounds, including antibiotics. The OM is asymmetric and contains an outer leaflet of lipopo
Externí odkaz:
https://doaj.org/article/3e878368b67745b59962862f6cdc5c94
Autor:
Eric M. Lynch, Heather Hansen, Lauren Salay, Madison Cooper, Stepan Timr, Justin M. Kollman, Bradley A. Webb
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Phosphofructokinase-1 (PFK1) catalyzes the rate-limiting step of glycolysis, committing glucose to conversion into cellular energy. PFK1 is highly regulated to respond to the changing energy needs of the cell. In bacteria, the structural bas
Externí odkaz:
https://doaj.org/article/2b92b0bfffbc4f84a0aa5d7fec0ee65d
Autor:
Rachael M Barry, Anne-Florence Bitbol, Alexander Lorestani, Emeric J Charles, Chris H Habrian, Jesse M Hansen, Hsin-Jung Li, Enoch P Baldwin, Ned S Wingreen, Justin M Kollman, Zemer Gitai
Publikováno v:
eLife, Vol 3 (2014)
CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring Ct
Externí odkaz:
https://doaj.org/article/b1fca865183544e1af06193fccf8b717
Autor:
Kelli L. Hvorecny, Thomas E. Sladewski, Enrique M. De La Cruz, Justin M. Kollman, Aoife T. Heaslip
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The cytoskeletal protein actin plays a critical role in the pathogenicity of the intracellular parasite, Toxoplasma gondii, mediating invasion and egress, cargo transport, and organelle inheritance. Advances in live cell imaging have reveale
Externí odkaz:
https://doaj.org/article/1d43f0d1417548e892e4eca50d7bf054
Publikováno v:
Nature Structural & Molecular Biology. 30:391-402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f345a2a83bdee2e39ec0576bb6061558
https://doi.org/10.1038/s41594-023-00921-z
https://doi.org/10.1038/s41594-023-00921-z
Autor:
Jacqueline C. Simonet, Maya J. Foster, Eric M. Lynch, Justin M. Kollman, Emmanuelle Nicholas, Alana M. O'Reilly, Jeffrey R. Peterson
Publikováno v:
Biology Open, Vol 9, Iss 7 (2020)
Polymerization of metabolic enzymes into micron-scale assemblies is an emerging mechanism for regulating their activity. CTP synthase (CTPS) is an essential enzyme in the biosynthesis of the nucleotide CTP and undergoes regulated and reversible assem
Externí odkaz:
https://doaj.org/article/86b5f1a866c8437689343481968ec4b5
Autor:
Audrey G O’Neill, Anika L Burrell, Michael Zech, Orly Elpeleg, Tamar Harel, Simon Edvardson, Hagar Mor Shaked, Alyssa L Rippert, Tomoki Nomakuchi, Kosuke Izumi, Justin M Kollman
Publikováno v:
bioRxiv
Inosine 5’ monophosphate dehydrogenase (IMPDH) is a critical regulatory enzyme in purine nucleotide biosynthesis that is inhibited by the downstream product GTP. Multiple point mutations in the human isoform IMPDH2 have recently been associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9193d0be8d04f82e75c69af528335290
https://europepmc.org/articles/PMC10055058/
https://europepmc.org/articles/PMC10055058/
