Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Justin M H Heltzel"'
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Akademický článek
A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis.
Autor: Michelle K Scotland, Justin M H Heltzel, James E Kath, Jung-Suk Choi, Anthony J Berdis, Joseph J Loparo, Mark D Sutton
Publikováno v: PLoS Genetics, Vol 11, Iss 9, p e1005507 (2015)
Translesion DNA synthesis (TLS) by specialized DNA polymerases (Pols) is a conserved mechanism for tolerating replication blocking DNA lesions. The actions of TLS Pols are managed in part by ring-shaped sliding clamp proteins. In addition to catalyzi
Externí odkaz: https://doaj.org/article/a93f1e5911504317a3253dcdaa0248cf
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2
Akademický článek
Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species
Autor: Christopher B. Rupert, Justin M. H. Heltzel, Derek J. Taylor, Laura N. Rusche
Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3297-3305 (2016)
Gene duplication promotes the diversification of protein functions in several ways. Ancestral functions can be partitioned between the paralogs, or a new function can arise in one paralog. These processes are generally viewed as unidirectional. Howev
Externí odkaz: https://doaj.org/article/5b6e1c5bf530401d940f4efb444676be
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3
Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species
Autor: Derek J. Taylor, Justin M. H. Heltzel, Laura N. Rusche, Christopher B. Rupert
Publikováno v: G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3297-3305 (2016)
Gene duplication promotes the diversification of protein functions in several ways. Ancestral functions can be partitioned between the paralogs, or a new function can arise in one paralog. These processes are generally viewed as unidirectional. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd25f1f8a3300a5671b5fbdab2939db3
http://europepmc.org/articles/PMC5068949
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4
Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
Autor: James E. Kath, Mark D. Sutton, Joseph J. Loparo, Slobodan Jergic, Deena T. Jacob, Justin M. H. Heltzel, Nicholas E. Dixon, Graham C. Walker
Publikováno v: Proceedings of the National Academy of Sciences. 111:7647-7652
Significance DNA damage can be a potent block to replication. One pathway to bypass damage is translesion synthesis (TLS) by specialized DNA polymerases. These conserved TLS polymerases have higher error rates than replicative polymerases, requiring
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca14188473de1a405e8a61798502978
https://doi.org/10.1073/pnas.1321076111
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5
Sliding Clamp–DNA Interactions Are Required for Viability and Contribute to DNA Polymerase Management in Escherichia coli
Autor: James Pace, Jill M. Duzen, Sarah K. Scouten Ponticelli, Edward H. Snell, Mark D. Sutton, Vivian Cody, Justin M. H. Heltzel, Laurie H. Sanders
Publikováno v: Journal of Molecular Biology. 387:74-91
Sliding clamp proteins topologically encircle DNA and play vital roles in coordinating the actions of various DNA replication, repair, and damage tolerance proteins. At least three distinct surfaces of the Escherichia coli beta clamp interact physica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c5bbf9e6e72e96eee4b8bfc4f187d6
https://doi.org/10.1016/j.jmb.2009.01.050
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6
A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis
Autor: Anthony J. Berdis, Jung Suk Choi, Joseph J. Loparo, Michelle K. Scotland, Justin M. H. Heltzel, James E. Kath, Mark D. Sutton
Publikováno v: PLoS Genetics, Vol 11, Iss 9, p e1005507 (2015)
PLoS Genetics
Translesion DNA synthesis (TLS) by specialized DNA polymerases (Pols) is a conserved mechanism for tolerating replication blocking DNA lesions. The actions of TLS Pols are managed in part by ring-shaped sliding clamp proteins. In addition to catalyzi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8522fea00e1f978b350e2e5b9a866a6
http://europepmc.org/articles/PMC4564189?pdf=render
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9
A model for DNA polymerase switching involving a single cleft and the rim of the sliding clamp
Autor: Robert W. Maul, Sarah K. Scouten Ponticelli, Mark D. Sutton, Justin M. H. Heltzel
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(31)
The actions of Escherichia coli DNA Polymerase IV (Pol IV) in mutagenesis are managed by its interaction with the β sliding clamp. In the structure reported by Bunting et al. [ EMBO J (2003) 22:5883–5892], the C-tail of Pol IV contacts a hydrophob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa347525744e6045dcfe18005450702
https://pubmed.ncbi.nlm.nih.gov/19617571
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